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Postoperative conjunctival inflammation after pterygium surgery with amniotic membrane transplantation versus conjunctival autograft.
Am J Ophthalmol. 2011 Nov; 152(5):733-8.AJ

Abstract

PURPOSE

To compare the postoperative conjunctival inflammation around the surgical site after pterygium surgery using either amniotic membrane transplantation (AMT) or free conjunctival autograft.

DESIGN

Prospective, randomized, interventional study.

METHODS

Forty-two eyes of 42 patients with primary pterygium underwent surgical excision followed by removal of subconjunctival fibrovascular tissue and intraoperative application of 0.02% mitomycin C. Then, the patients were randomized to receive either AMT (21 eyes) or free conjunctival autograft (21 eyes), with sutures used in both groups. Main outcome measures included presence of host conjunctival inflammation around the surgical site at 1 month after surgery and also recurrence of pterygium.

RESULTS

Twelve-month follow-up was completed in 39 eyes of 39 patients (19 in the AMT group and 20 in the conjunctival autograft group). At 1 month after surgery, different grades of host conjunctival inflammation were present in 16 eyes (84.2%) in the AMT group and in 3 eyes (15%) in the conjunctival autograft group (P = .02). Subconjunctival injection of triamcinolone was performed in eyes with moderate or severe inflammation, which included 12 eyes (63.1%) in the AMT group and 2 eyes (10%) in the conjunctival autograft group (P < .001). Conjunctival recurrence of pterygium was seen in 2 eyes (10.5%) in the AMT group and in 2 eyes (10%) in the conjunctival autograft group (P = .92). After surgery, pyogenic granuloma developed in 3 eyes (15.8%) in the AMT group and in 1 eye (5%) in the conjunctival autograft group (P = .31).

CONCLUSIONS

After pterygium surgery, conjunctival inflammation was significantly more common with AMT than with conjunctival autograft. However, with control of such inflammation and intraoperative application of mitomycin C, similar final outcomes were achieved with both techniques.

Authors+Show Affiliations

Farabi Eye Hospital, Eye Research Center, Tehran University of Medical Sciences, Tehran, Iran. Akheirkh@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

21742306

Citation

Kheirkhah, Ahmad, et al. "Postoperative Conjunctival Inflammation After Pterygium Surgery With Amniotic Membrane Transplantation Versus Conjunctival Autograft." American Journal of Ophthalmology, vol. 152, no. 5, 2011, pp. 733-8.
Kheirkhah A, Nazari R, Nikdel M, et al. Postoperative conjunctival inflammation after pterygium surgery with amniotic membrane transplantation versus conjunctival autograft. Am J Ophthalmol. 2011;152(5):733-8.
Kheirkhah, A., Nazari, R., Nikdel, M., Ghassemi, H., Hashemi, H., & Behrouz, M. J. (2011). Postoperative conjunctival inflammation after pterygium surgery with amniotic membrane transplantation versus conjunctival autograft. American Journal of Ophthalmology, 152(5), 733-8. https://doi.org/10.1016/j.ajo.2011.04.013
Kheirkhah A, et al. Postoperative Conjunctival Inflammation After Pterygium Surgery With Amniotic Membrane Transplantation Versus Conjunctival Autograft. Am J Ophthalmol. 2011;152(5):733-8. PubMed PMID: 21742306.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Postoperative conjunctival inflammation after pterygium surgery with amniotic membrane transplantation versus conjunctival autograft. AU - Kheirkhah,Ahmad, AU - Nazari,Rahman, AU - Nikdel,Mojgan, AU - Ghassemi,Hamed, AU - Hashemi,Hassan, AU - Behrouz,Mahmoud Jabbarvand, Y1 - 2011/07/13/ PY - 2010/12/20/received PY - 2011/04/03/revised PY - 2011/04/06/accepted PY - 2011/7/12/entrez PY - 2011/7/12/pubmed PY - 2011/12/15/medline SP - 733 EP - 8 JF - American journal of ophthalmology JO - Am J Ophthalmol VL - 152 IS - 5 N2 - PURPOSE: To compare the postoperative conjunctival inflammation around the surgical site after pterygium surgery using either amniotic membrane transplantation (AMT) or free conjunctival autograft. DESIGN: Prospective, randomized, interventional study. METHODS: Forty-two eyes of 42 patients with primary pterygium underwent surgical excision followed by removal of subconjunctival fibrovascular tissue and intraoperative application of 0.02% mitomycin C. Then, the patients were randomized to receive either AMT (21 eyes) or free conjunctival autograft (21 eyes), with sutures used in both groups. Main outcome measures included presence of host conjunctival inflammation around the surgical site at 1 month after surgery and also recurrence of pterygium. RESULTS: Twelve-month follow-up was completed in 39 eyes of 39 patients (19 in the AMT group and 20 in the conjunctival autograft group). At 1 month after surgery, different grades of host conjunctival inflammation were present in 16 eyes (84.2%) in the AMT group and in 3 eyes (15%) in the conjunctival autograft group (P = .02). Subconjunctival injection of triamcinolone was performed in eyes with moderate or severe inflammation, which included 12 eyes (63.1%) in the AMT group and 2 eyes (10%) in the conjunctival autograft group (P < .001). Conjunctival recurrence of pterygium was seen in 2 eyes (10.5%) in the AMT group and in 2 eyes (10%) in the conjunctival autograft group (P = .92). After surgery, pyogenic granuloma developed in 3 eyes (15.8%) in the AMT group and in 1 eye (5%) in the conjunctival autograft group (P = .31). CONCLUSIONS: After pterygium surgery, conjunctival inflammation was significantly more common with AMT than with conjunctival autograft. However, with control of such inflammation and intraoperative application of mitomycin C, similar final outcomes were achieved with both techniques. SN - 1879-1891 UR - https://www.unboundmedicine.com/medline/citation/21742306/Postoperative_conjunctival_inflammation_after_pterygium_surgery_with_amniotic_membrane_transplantation_versus_conjunctival_autograft_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(11)00324-2 DB - PRIME DP - Unbound Medicine ER -