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No influence on disease progression of non-HLA susceptibility genes in MS.
J Neuroimmunol 2011; 237(1-2):98-100JN

Abstract

Recently, several non-HLA loci have been shown to be convincingly associated with Multiple Sclerosis (MS) susceptibility, assumingly indicating important pathways in the pathogenesis. A genotype influence on disease outcome measures by these genes would support a role of these pathways in ongoing tissue damage. Here, however, we report a consistent dissociation between causation and progression for five non-HLA genotypes (IL7R, IL2RA, CLEC16A, CD226 and SH2B3) in 1776 Scandinavian MS patients.

Authors+Show Affiliations

The Multiple Sclerosis Research group, Centre for Molecular Medicine, Department of Clinical neuroscience, Karolinska Institutet, Stockholm, Sweden. wangko.lundstrom@ki.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21742385

Citation

Lundström, Wangko, et al. "No Influence On Disease Progression of non-HLA Susceptibility Genes in MS." Journal of Neuroimmunology, vol. 237, no. 1-2, 2011, pp. 98-100.
Lundström W, Greiner E, Lundmark F, et al. No influence on disease progression of non-HLA susceptibility genes in MS. J Neuroimmunol. 2011;237(1-2):98-100.
Lundström, W., Greiner, E., Lundmark, F., Westerlind, H., Smestad, C., Lorentzen, A. R., ... Hillert, J. (2011). No influence on disease progression of non-HLA susceptibility genes in MS. Journal of Neuroimmunology, 237(1-2), pp. 98-100. doi:10.1016/j.jneuroim.2011.05.003.
Lundström W, et al. No Influence On Disease Progression of non-HLA Susceptibility Genes in MS. J Neuroimmunol. 2011 Aug 15;237(1-2):98-100. PubMed PMID: 21742385.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - No influence on disease progression of non-HLA susceptibility genes in MS. AU - Lundström,Wangko, AU - Greiner,Eva, AU - Lundmark,Frida, AU - Westerlind,Helga, AU - Smestad,Cathrine, AU - Lorentzen,Aslaug R, AU - Kockum,Ingrid, AU - Link,Jenny, AU - Brynedal,Boel, AU - Celius,Elisabeth G, AU - Harbo,Hanne F, AU - Masterman,Thomas, AU - Hillert,Jan, Y1 - 2011/07/13/ PY - 2011/03/30/received PY - 2011/05/03/revised PY - 2011/05/06/accepted PY - 2011/7/12/entrez PY - 2011/7/12/pubmed PY - 2011/10/18/medline SP - 98 EP - 100 JF - Journal of neuroimmunology JO - J. Neuroimmunol. VL - 237 IS - 1-2 N2 - Recently, several non-HLA loci have been shown to be convincingly associated with Multiple Sclerosis (MS) susceptibility, assumingly indicating important pathways in the pathogenesis. A genotype influence on disease outcome measures by these genes would support a role of these pathways in ongoing tissue damage. Here, however, we report a consistent dissociation between causation and progression for five non-HLA genotypes (IL7R, IL2RA, CLEC16A, CD226 and SH2B3) in 1776 Scandinavian MS patients. SN - 1872-8421 UR - https://www.unboundmedicine.com/medline/citation/21742385/No_influence_on_disease_progression_of_non_HLA_susceptibility_genes_in_MS_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-5728(11)00132-9 DB - PRIME DP - Unbound Medicine ER -