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Maesopsin 4-O-beta-D-glucoside, a natural compound isolated from the leaves of Artocarpus tonkinensis, inhibits proliferation and up-regulates HMOX1, SRXN1 and BCAS3 in acute myeloid leukemia.
J Chemother. 2011 06; 23(3):150-7.JC

Abstract

The leaves of Artocarpus tonkinensis are used in Vietnamese traditional medicine for treatment of arthritis, and the compound maesopsin 4-O-β-D-glucoside (TAT-2), isolated from them, inhibits the proliferation of activated T cells. Our goal was to test the anti-proliferative activity of TAT-2 on the T-cell leukemia, Jurkat, and on the acute myeloid leukemia, OCI-AML. TAT-2 inhibited the growth of OCI-AML (and additional acute myeloid leukemia cells) but not Jurkat cells. Growth inhibition was shown to be due to inhibition of proliferation rather than increase in cell death. Analysis of cytokine release showed that TAT-2 stimulated the release of TGF-β, yet TGF-β neutralization did not reverse the maesopsin-dependent effect. Gene expression profiling determined that maesopsin modulated 19 identifiable genes. Transcription factor CP2 was the gene most significantly modulated. Real-time PCR validated that up-regulation of sulphiredoxin 1 homolog (SRXN1), hemeoxygenase 1 (HMOX1), and breast carcinoma amplified sequence 3 (BCAS3) were consistently modulated.

Authors+Show Affiliations

Section of Pharmacology, Toxicology and Chemotherapy, Department of Clinical and Experimental Medicine, University of Perugia, Via del Giochetto, Perugia, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21742584

Citation

Pozzesi, N, et al. "Maesopsin 4-O-beta-D-glucoside, a Natural Compound Isolated From the Leaves of Artocarpus Tonkinensis, Inhibits Proliferation and Up-regulates HMOX1, SRXN1 and BCAS3 in Acute Myeloid Leukemia." Journal of Chemotherapy (Florence, Italy), vol. 23, no. 3, 2011, pp. 150-7.
Pozzesi N, Pierangeli S, Vacca C, et al. Maesopsin 4-O-beta-D-glucoside, a natural compound isolated from the leaves of Artocarpus tonkinensis, inhibits proliferation and up-regulates HMOX1, SRXN1 and BCAS3 in acute myeloid leukemia. J Chemother. 2011;23(3):150-7.
Pozzesi, N., Pierangeli, S., Vacca, C., Falchi, L., Pettorossi, V., Martelli, M. P., Thuy, T. T., Ninh, P. T., Liberati, A. M., Riccardi, C., Sung, T. V., & Delfino, D. V. (2011). Maesopsin 4-O-beta-D-glucoside, a natural compound isolated from the leaves of Artocarpus tonkinensis, inhibits proliferation and up-regulates HMOX1, SRXN1 and BCAS3 in acute myeloid leukemia. Journal of Chemotherapy (Florence, Italy), 23(3), 150-7.
Pozzesi N, et al. Maesopsin 4-O-beta-D-glucoside, a Natural Compound Isolated From the Leaves of Artocarpus Tonkinensis, Inhibits Proliferation and Up-regulates HMOX1, SRXN1 and BCAS3 in Acute Myeloid Leukemia. J Chemother. 2011;23(3):150-7. PubMed PMID: 21742584.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maesopsin 4-O-beta-D-glucoside, a natural compound isolated from the leaves of Artocarpus tonkinensis, inhibits proliferation and up-regulates HMOX1, SRXN1 and BCAS3 in acute myeloid leukemia. AU - Pozzesi,N, AU - Pierangeli,S, AU - Vacca,Carmine, AU - Falchi,L, AU - Pettorossi,V, AU - Martelli,M P, AU - Thuy,T T, AU - Ninh,P T, AU - Liberati,A M, AU - Riccardi,C, AU - Sung,T V, AU - Delfino,D V, PY - 2011/7/12/entrez PY - 2011/7/12/pubmed PY - 2011/12/16/medline SP - 150 EP - 7 JF - Journal of chemotherapy (Florence, Italy) JO - J Chemother VL - 23 IS - 3 N2 - The leaves of Artocarpus tonkinensis are used in Vietnamese traditional medicine for treatment of arthritis, and the compound maesopsin 4-O-β-D-glucoside (TAT-2), isolated from them, inhibits the proliferation of activated T cells. Our goal was to test the anti-proliferative activity of TAT-2 on the T-cell leukemia, Jurkat, and on the acute myeloid leukemia, OCI-AML. TAT-2 inhibited the growth of OCI-AML (and additional acute myeloid leukemia cells) but not Jurkat cells. Growth inhibition was shown to be due to inhibition of proliferation rather than increase in cell death. Analysis of cytokine release showed that TAT-2 stimulated the release of TGF-β, yet TGF-β neutralization did not reverse the maesopsin-dependent effect. Gene expression profiling determined that maesopsin modulated 19 identifiable genes. Transcription factor CP2 was the gene most significantly modulated. Real-time PCR validated that up-regulation of sulphiredoxin 1 homolog (SRXN1), hemeoxygenase 1 (HMOX1), and breast carcinoma amplified sequence 3 (BCAS3) were consistently modulated. SN - 1973-9478 UR - https://www.unboundmedicine.com/medline/citation/21742584/Maesopsin_4_O_beta_D_glucoside_a_natural_compound_isolated_from_the_leaves_of_Artocarpus_tonkinensis_inhibits_proliferation_and_up_regulates_HMOX1_SRXN1_and_BCAS3_in_acute_myeloid_leukemia_ L2 - https://www.tandfonline.com/doi/full/10.1179/joc.2011.23.3.150 DB - PRIME DP - Unbound Medicine ER -