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Estrogen levels in nipple aspirate fluid and serum during a randomized soy trial.
Cancer Epidemiol Biomarkers Prev 2011; 20(9):1815-21CE

Abstract

BACKGROUND

On the basis of hypothesized protective effect, we examined the effect of soy foods on estrogens in nipple aspirate fluid (NAF) and serum, possible indicators of breast cancer risk.

METHODS

In a crossover design, we randomized 96 women who produced 10 μL or more NAF to a high- or low-soy diet for 6 months. During the high-soy diet, participants consumed 2 soy servings of soy milk, tofu, or soy nuts (∼50 mg of isoflavones per day); during the low-soy diet, they maintained their usual diet. Six NAF samples were obtained using a FirstCyte aspirator. Estradiol (E(2)) and estrone sulfate (E(1)S) were assessed in NAF and estrone (E(1)) in serum only, using highly sensitive radioimmunoassays. Mixed-effects regression models accounting for repeated measures and left-censoring limits were applied.

RESULTS

Mean E(2) and E(1)S were lower during the high-soy than the low-soy diet (113 vs. 313 pg/mL and 46 vs. 68 ng/mL, respectively) without reaching significance (P = 0.07); the interaction between group and diet was not significant. There was no effect of the soy treatment on serum levels of E(2) (P = 0.76), E(1) (P = 0.86), or E(1)S (P = 0.56). Within individuals, NAF and serum levels of E(2) (r(s) = 0.37; P < 0.001) but not of E(1)S (r(s) = 0.004; P = 0.97) were correlated. E(2) and E(1)S in NAF and serum were strongly associated (r(s) = 0.78 and r(s) = 0.48; P < 0.001).

CONCLUSION

Soy foods in amounts consumed by Asians did not significantly modify estrogen levels in NAF and serum.

IMPACT

The trend toward lower estrogen levels in NAF during the high-soy diet counters concerns about adverse effects of soy foods on breast cancer risk.

Authors+Show Affiliations

University of Hawaii Cancer Center, 1236 Lauhala Street, Honolulu, HI 96813, USA. gertraud@cc.hawaii.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

21742946

Citation

Maskarinec, Gertraud, et al. "Estrogen Levels in Nipple Aspirate Fluid and Serum During a Randomized Soy Trial." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 20, no. 9, 2011, pp. 1815-21.
Maskarinec G, Ollberding NJ, Conroy SM, et al. Estrogen levels in nipple aspirate fluid and serum during a randomized soy trial. Cancer Epidemiol Biomarkers Prev. 2011;20(9):1815-21.
Maskarinec, G., Ollberding, N. J., Conroy, S. M., Morimoto, Y., Pagano, I. S., Franke, A. A., ... Stanczyk, F. Z. (2011). Estrogen levels in nipple aspirate fluid and serum during a randomized soy trial. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 20(9), pp. 1815-21. doi:10.1158/1055-9965.EPI-11-0363.
Maskarinec G, et al. Estrogen Levels in Nipple Aspirate Fluid and Serum During a Randomized Soy Trial. Cancer Epidemiol Biomarkers Prev. 2011;20(9):1815-21. PubMed PMID: 21742946.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Estrogen levels in nipple aspirate fluid and serum during a randomized soy trial. AU - Maskarinec,Gertraud, AU - Ollberding,Nicholas J, AU - Conroy,Shannon M, AU - Morimoto,Yukiko, AU - Pagano,Ian S, AU - Franke,Adrian A, AU - Gentzschein,Elisabet, AU - Stanczyk,Frank Z, Y1 - 2011/07/08/ PY - 2011/7/12/entrez PY - 2011/7/12/pubmed PY - 2012/3/23/medline SP - 1815 EP - 21 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 20 IS - 9 N2 - BACKGROUND: On the basis of hypothesized protective effect, we examined the effect of soy foods on estrogens in nipple aspirate fluid (NAF) and serum, possible indicators of breast cancer risk. METHODS: In a crossover design, we randomized 96 women who produced 10 μL or more NAF to a high- or low-soy diet for 6 months. During the high-soy diet, participants consumed 2 soy servings of soy milk, tofu, or soy nuts (∼50 mg of isoflavones per day); during the low-soy diet, they maintained their usual diet. Six NAF samples were obtained using a FirstCyte aspirator. Estradiol (E(2)) and estrone sulfate (E(1)S) were assessed in NAF and estrone (E(1)) in serum only, using highly sensitive radioimmunoassays. Mixed-effects regression models accounting for repeated measures and left-censoring limits were applied. RESULTS: Mean E(2) and E(1)S were lower during the high-soy than the low-soy diet (113 vs. 313 pg/mL and 46 vs. 68 ng/mL, respectively) without reaching significance (P = 0.07); the interaction between group and diet was not significant. There was no effect of the soy treatment on serum levels of E(2) (P = 0.76), E(1) (P = 0.86), or E(1)S (P = 0.56). Within individuals, NAF and serum levels of E(2) (r(s) = 0.37; P < 0.001) but not of E(1)S (r(s) = 0.004; P = 0.97) were correlated. E(2) and E(1)S in NAF and serum were strongly associated (r(s) = 0.78 and r(s) = 0.48; P < 0.001). CONCLUSION: Soy foods in amounts consumed by Asians did not significantly modify estrogen levels in NAF and serum. IMPACT: The trend toward lower estrogen levels in NAF during the high-soy diet counters concerns about adverse effects of soy foods on breast cancer risk. SN - 1538-7755 UR - https://www.unboundmedicine.com/medline/citation/21742946/Estrogen_levels_in_nipple_aspirate_fluid_and_serum_during_a_randomized_soy_trial_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&amp;pmid=21742946 DB - PRIME DP - Unbound Medicine ER -