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Milk-based phospholipids increase morning cortisol availability and improve memory in chronically stressed men.
Nutr Res. 2011 Jun; 31(6):413-20.NR

Abstract

Phospholipids (PLs) have been shown to dampen the activity and reactivity of the hypothalamic-pituitary-adrenal axis (HPAA). To further investigate stress protective effects of PL, 75 chronically stressed men aged 30 to 51 years were enrolled in a randomized and placebo-controlled trial. The subjects received a bovine milk drink with either 0.5% PL, 1% PL, or a placebo for 42 days to test the hypothesis that supplementation with specific phospholipids would normalize the cortisol response of the HPAA. For determining HPAA activity, the cortisol awakening response was studied before and after treatment. In addition, participants were exposed to an acute stressor, the Trier Social Stress Test, to assess treatment effects on stress reactivity and stress-related memory impairment. After receiving PL-enriched milk, both PL groups showed a delayed decline from peak levels in morning salivary cortisol, suggesting a prolonged availability of free cortisol. Treatment with 0.5% PL additionally resulted in a stronger increase of cortisol after awakening, whereas no such differences could be observed in the 1% PL group and the placebo group, respectively. The acute stress response did not significantly differ among placebo and PL groups. An exploratory data analysis further revealed that elderly participants receiving the higher PL dosage had a significant better memory performance after the Trier Social Stress Test as compared with elderly participants from the placebo and low-PL dosage group; no such difference was observed at baseline. Our results suggest that PL may increase the availability of cortisol in chronically stressed men and may attenuate stress-induced memory impairments. Results of the present study are discussed within the context of previous research and current state of knowledge.

Authors+Show Affiliations

Diagnostic Assessment and Clinical Research Organization (Daacro), Science Park Trier, Max-Planck-Str. 22, D-54296 Trier, Germany. schubert@daacro.deNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21745622

Citation

Schubert, Melanie, et al. "Milk-based Phospholipids Increase Morning Cortisol Availability and Improve Memory in Chronically Stressed Men." Nutrition Research (New York, N.Y.), vol. 31, no. 6, 2011, pp. 413-20.
Schubert M, Contreras C, Franz N, et al. Milk-based phospholipids increase morning cortisol availability and improve memory in chronically stressed men. Nutr Res. 2011;31(6):413-20.
Schubert, M., Contreras, C., Franz, N., & Hellhammer, J. (2011). Milk-based phospholipids increase morning cortisol availability and improve memory in chronically stressed men. Nutrition Research (New York, N.Y.), 31(6), 413-20. https://doi.org/10.1016/j.nutres.2011.05.012
Schubert M, et al. Milk-based Phospholipids Increase Morning Cortisol Availability and Improve Memory in Chronically Stressed Men. Nutr Res. 2011;31(6):413-20. PubMed PMID: 21745622.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Milk-based phospholipids increase morning cortisol availability and improve memory in chronically stressed men. AU - Schubert,Melanie, AU - Contreras,Carina, AU - Franz,Nadin, AU - Hellhammer,Juliane, PY - 2011/03/04/received PY - 2011/05/28/revised PY - 2011/05/31/accepted PY - 2011/7/13/entrez PY - 2011/7/13/pubmed PY - 2011/12/13/medline SP - 413 EP - 20 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 31 IS - 6 N2 - Phospholipids (PLs) have been shown to dampen the activity and reactivity of the hypothalamic-pituitary-adrenal axis (HPAA). To further investigate stress protective effects of PL, 75 chronically stressed men aged 30 to 51 years were enrolled in a randomized and placebo-controlled trial. The subjects received a bovine milk drink with either 0.5% PL, 1% PL, or a placebo for 42 days to test the hypothesis that supplementation with specific phospholipids would normalize the cortisol response of the HPAA. For determining HPAA activity, the cortisol awakening response was studied before and after treatment. In addition, participants were exposed to an acute stressor, the Trier Social Stress Test, to assess treatment effects on stress reactivity and stress-related memory impairment. After receiving PL-enriched milk, both PL groups showed a delayed decline from peak levels in morning salivary cortisol, suggesting a prolonged availability of free cortisol. Treatment with 0.5% PL additionally resulted in a stronger increase of cortisol after awakening, whereas no such differences could be observed in the 1% PL group and the placebo group, respectively. The acute stress response did not significantly differ among placebo and PL groups. An exploratory data analysis further revealed that elderly participants receiving the higher PL dosage had a significant better memory performance after the Trier Social Stress Test as compared with elderly participants from the placebo and low-PL dosage group; no such difference was observed at baseline. Our results suggest that PL may increase the availability of cortisol in chronically stressed men and may attenuate stress-induced memory impairments. Results of the present study are discussed within the context of previous research and current state of knowledge. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/21745622/Milk_based_phospholipids_increase_morning_cortisol_availability_and_improve_memory_in_chronically_stressed_men_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(11)00115-1 DB - PRIME DP - Unbound Medicine ER -