Tags

Type your tag names separated by a space and hit enter

Anti-inflammatory and analgesic activity of protocatechuic acid in rats and mice.
Inflammopharmacology. 2011 Oct; 19(5):255-63.I

Abstract

Anti-inflammatory and analgesic activity of protocatechuic acid (PCA), a natural product, was evaluated in different rat models (viz., carrageenan-induced paw oedema, cotton pellet-induced granuloma and Freund's adjuvant arthritis) of inflammation and chemical and heat induced mouse models of pain. Treatment with PCA inhibited significantly different biological parameters like hind paw oedema, granuloma exudates formation and arthritis index in carrageenan oedema, cotton pellet granuloma and Freund's adjuvant arthritis, respectively. The biochemical changes viz., glutathione, superoxide dismutase, catalase, lipid peroxidation and NO in oedematous or in liver tissues and serum alanine aminotransferase and lactic dehydrogenase occurred during different types of inflammation were either significantly restored or inhibited with PCA pretreatment. Present experimental findings demonstrate promising anti-inflammatory and analgesic activity of PCA which is comparable with that of standard drugs used.

Authors+Show Affiliations

Department of Pharmacology, Pad. Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, 411 018, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21748471

Citation

Lende, Amol B., et al. "Anti-inflammatory and Analgesic Activity of Protocatechuic Acid in Rats and Mice." Inflammopharmacology, vol. 19, no. 5, 2011, pp. 255-63.
Lende AB, Kshirsagar AD, Deshpande AD, et al. Anti-inflammatory and analgesic activity of protocatechuic acid in rats and mice. Inflammopharmacology. 2011;19(5):255-63.
Lende, A. B., Kshirsagar, A. D., Deshpande, A. D., Muley, M. M., Patil, R. R., Bafna, P. A., & Naik, S. R. (2011). Anti-inflammatory and analgesic activity of protocatechuic acid in rats and mice. Inflammopharmacology, 19(5), 255-63. https://doi.org/10.1007/s10787-011-0086-4
Lende AB, et al. Anti-inflammatory and Analgesic Activity of Protocatechuic Acid in Rats and Mice. Inflammopharmacology. 2011;19(5):255-63. PubMed PMID: 21748471.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory and analgesic activity of protocatechuic acid in rats and mice. AU - Lende,Amol B, AU - Kshirsagar,Ajay D, AU - Deshpande,Avinash D, AU - Muley,Milind M, AU - Patil,Rajesh Ramesh, AU - Bafna,Pallavi A, AU - Naik,Suresh R, Y1 - 2011/07/12/ PY - 2010/10/22/received PY - 2011/05/02/accepted PY - 2011/7/13/entrez PY - 2011/7/13/pubmed PY - 2012/3/9/medline SP - 255 EP - 63 JF - Inflammopharmacology JO - Inflammopharmacology VL - 19 IS - 5 N2 - Anti-inflammatory and analgesic activity of protocatechuic acid (PCA), a natural product, was evaluated in different rat models (viz., carrageenan-induced paw oedema, cotton pellet-induced granuloma and Freund's adjuvant arthritis) of inflammation and chemical and heat induced mouse models of pain. Treatment with PCA inhibited significantly different biological parameters like hind paw oedema, granuloma exudates formation and arthritis index in carrageenan oedema, cotton pellet granuloma and Freund's adjuvant arthritis, respectively. The biochemical changes viz., glutathione, superoxide dismutase, catalase, lipid peroxidation and NO in oedematous or in liver tissues and serum alanine aminotransferase and lactic dehydrogenase occurred during different types of inflammation were either significantly restored or inhibited with PCA pretreatment. Present experimental findings demonstrate promising anti-inflammatory and analgesic activity of PCA which is comparable with that of standard drugs used. SN - 1568-5608 UR - https://www.unboundmedicine.com/medline/citation/21748471/Anti_inflammatory_and_analgesic_activity_of_protocatechuic_acid_in_rats_and_mice_ L2 - https://dx.doi.org/10.1007/s10787-011-0086-4 DB - PRIME DP - Unbound Medicine ER -