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Hydroalcoholic extract of Emblica officinalis protects against kainic acid-induced status epilepticus in rats: evidence for an antioxidant, anti-inflammatory, and neuroprotective intervention.
Pharm Biol. 2011 Nov; 49(11):1128-36.PB

Abstract

CONTEXT

Emblica officinalis (Euphorbiaceae), commonly known as amla, is traditionally used for central nervous system (CNS) disorders.

OBJECTIVE

In the present study, the effect of standardized hydroalcoholic extract of E. officinalis fruit (HAEEO), an Indian medicinal plant with potent antioxidant activity, was studied against kainic acid (KA)-induced seizures, cognitive deficits and on markers of oxidative stress.

MATERIALS AND METHODS

Rats were administered KA (10 mg/kg, i.p.) and observed for behavioral changes, incidence, and latency of convulsions over 4 h. The rats were thereafter sacrificed for estimation of oxidative stress parameters: thiobarbituric acid-reactive substances (TBARS) and glutathione (GSH). The proinflammatory cytokine tumor necrosis factor alpha (TNF-α) was also determined in the rat brain.

RESULTS

Pretreatment with HAEEO (500 and 700 mg/kg, i.p.) significantly (P < 0.001) increased the latency of seizures as compared with the vehicle-treated KA group. HAEEO significantly prevented the increase in TBARS levels and ameliorated the fall in GSH. Furthermore, HAEEO dose-dependently attenuated the KA-induced increase in the TNF-α level in the brain. HAEEO also significantly improved the cognitive deficit induced by KA, as evidenced by increased latency in passive avoidance task.

DISCUSSION AND CONCLUSION

HAEEO at the dose of 700 mg/kg, i.p., was most effective in suppressing KA-induced seizures, cognitive decline, and oxidative stress in the brain. These neuroprotective effects may be due to the antioxidant and anti-inflammatory effects of HAEEO.

Authors+Show Affiliations

Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21749189

Citation

Golechha, Mahaveer, et al. "Hydroalcoholic Extract of Emblica Officinalis Protects Against Kainic Acid-induced Status Epilepticus in Rats: Evidence for an Antioxidant, Anti-inflammatory, and Neuroprotective Intervention." Pharmaceutical Biology, vol. 49, no. 11, 2011, pp. 1128-36.
Golechha M, Bhatia J, Ojha S, et al. Hydroalcoholic extract of Emblica officinalis protects against kainic acid-induced status epilepticus in rats: evidence for an antioxidant, anti-inflammatory, and neuroprotective intervention. Pharm Biol. 2011;49(11):1128-36.
Golechha, M., Bhatia, J., Ojha, S., & Arya, D. S. (2011). Hydroalcoholic extract of Emblica officinalis protects against kainic acid-induced status epilepticus in rats: evidence for an antioxidant, anti-inflammatory, and neuroprotective intervention. Pharmaceutical Biology, 49(11), 1128-36. https://doi.org/10.3109/13880209.2011.571264
Golechha M, et al. Hydroalcoholic Extract of Emblica Officinalis Protects Against Kainic Acid-induced Status Epilepticus in Rats: Evidence for an Antioxidant, Anti-inflammatory, and Neuroprotective Intervention. Pharm Biol. 2011;49(11):1128-36. PubMed PMID: 21749189.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hydroalcoholic extract of Emblica officinalis protects against kainic acid-induced status epilepticus in rats: evidence for an antioxidant, anti-inflammatory, and neuroprotective intervention. AU - Golechha,Mahaveer, AU - Bhatia,Jagriti, AU - Ojha,Shreesh, AU - Arya,Dharmveer Singh, Y1 - 2011/07/12/ PY - 2011/7/14/entrez PY - 2011/7/14/pubmed PY - 2012/7/31/medline SP - 1128 EP - 36 JF - Pharmaceutical biology JO - Pharm Biol VL - 49 IS - 11 N2 - CONTEXT: Emblica officinalis (Euphorbiaceae), commonly known as amla, is traditionally used for central nervous system (CNS) disorders. OBJECTIVE: In the present study, the effect of standardized hydroalcoholic extract of E. officinalis fruit (HAEEO), an Indian medicinal plant with potent antioxidant activity, was studied against kainic acid (KA)-induced seizures, cognitive deficits and on markers of oxidative stress. MATERIALS AND METHODS: Rats were administered KA (10 mg/kg, i.p.) and observed for behavioral changes, incidence, and latency of convulsions over 4 h. The rats were thereafter sacrificed for estimation of oxidative stress parameters: thiobarbituric acid-reactive substances (TBARS) and glutathione (GSH). The proinflammatory cytokine tumor necrosis factor alpha (TNF-α) was also determined in the rat brain. RESULTS: Pretreatment with HAEEO (500 and 700 mg/kg, i.p.) significantly (P < 0.001) increased the latency of seizures as compared with the vehicle-treated KA group. HAEEO significantly prevented the increase in TBARS levels and ameliorated the fall in GSH. Furthermore, HAEEO dose-dependently attenuated the KA-induced increase in the TNF-α level in the brain. HAEEO also significantly improved the cognitive deficit induced by KA, as evidenced by increased latency in passive avoidance task. DISCUSSION AND CONCLUSION: HAEEO at the dose of 700 mg/kg, i.p., was most effective in suppressing KA-induced seizures, cognitive decline, and oxidative stress in the brain. These neuroprotective effects may be due to the antioxidant and anti-inflammatory effects of HAEEO. SN - 1744-5116 UR - https://www.unboundmedicine.com/medline/citation/21749189/Hydroalcoholic_extract_of_Emblica_officinalis_protects_against_kainic_acid_induced_status_epilepticus_in_rats:_evidence_for_an_antioxidant_anti_inflammatory_and_neuroprotective_intervention_ L2 - https://www.tandfonline.com/doi/full/10.3109/13880209.2011.571264 DB - PRIME DP - Unbound Medicine ER -