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Is the plasma anti-Müllerian hormone (AMH) level associated with body weight and metabolic, and hormonal disturbances in women with and without polycystic ovary syndrome?
Eur J Obstet Gynecol Reprod Biol. 2011 Oct; 158(2):254-9.EJ

Abstract

OBJECTIVE

The aim of the study was to analyze interrelation between AMH levels and body weight, metabolic, and hormonal status in normal and overweight weight women with and without polycystic ovary syndrome (PCOS).

STUDY DESIGN

Eighty-seven women (54 normal weight and 33 overweight) diagnosed with PCOS and 50 apparently healthy women - Non-PCOS (28 normal weight and 22 overweight) were enrolled. The body weight and height were measured and BMI was calculated. In addition to serum glucose, lipids, androgens, FSH, LH, SHBG and insulin, AMH were assessed in fasting state and free androgens index (FAI) was calculated. The insulin resistance was assessed based on the homeostasis model of assessment-insulin resistance (HOMA-IR).

RESULTS

Plasma AMH levels were similar in normal weight and overweight PCOS groups (9.6±3.5 vs. 11.2±4.5ng/mL, respectively), and as expected markedly higher than in both Non-PCOS groups (2.5±0.8 and 2.3±0.7ng/mL, respectively). There were no correlations between BMI and AMH levels in all study groups. A significant positive correlation between HOMA-IR, free testosterone concentrations or FAI and AMH levels were found (R=0.31, p<0.001; R=0.91, p<0.001 and R=0.62, p<0.001, respectively). Moreover, there was positive correlation between total or LDL cholesterol and AMH levels (R=0.22, p<0.05 and R=0.31, p<0.05, respectively) and a negative one between HDL cholesterol and AMH levels (R=-0.17, p<0.05) in all study subjects.

CONCLUSIONS

The plasma AMH level is associated with insulin resistance but not with BMI per se. Increased circulating AMH level seems to reflect the disturbances of gonadotrophins release in PCOS. It seems that AMH level may be used not only as new surrogate marker of ovarian hyperandrogenism in PCOS but also as a potential new cardiovascular risk factor.

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Authors+Show Affiliations

Skałba P
Department of Endocrinological Gynecology, Medical University of Silesia, Katowice, Poland.
Cygal A
No affiliation info available
Madej P
No affiliation info available
Dąbkowska-Huć A
No affiliation info available
Sikora J
No affiliation info available
Martirosian G
No affiliation info available
Romanik M
No affiliation info available
Olszanecka-Glinianowicz M
No affiliation info available

MeSH

AdultAnti-Mullerian HormoneBiomarkersBody Mass IndexBody WeightFemaleFollicle Stimulating HormoneGonadotropinsHumansInsulin ResistanceOverweightPolycystic Ovary SyndromeYoung Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21752527

Citation

Skałba, Piotr, et al. "Is the Plasma anti-Müllerian Hormone (AMH) Level Associated With Body Weight and Metabolic, and Hormonal Disturbances in Women With and Without Polycystic Ovary Syndrome?" European Journal of Obstetrics, Gynecology, and Reproductive Biology, vol. 158, no. 2, 2011, pp. 254-9.
Skałba P, Cygal A, Madej P, et al. Is the plasma anti-Müllerian hormone (AMH) level associated with body weight and metabolic, and hormonal disturbances in women with and without polycystic ovary syndrome? Eur J Obstet Gynecol Reprod Biol. 2011;158(2):254-9.
Skałba, P., Cygal, A., Madej, P., Dąbkowska-Huć, A., Sikora, J., Martirosian, G., Romanik, M., & Olszanecka-Glinianowicz, M. (2011). Is the plasma anti-Müllerian hormone (AMH) level associated with body weight and metabolic, and hormonal disturbances in women with and without polycystic ovary syndrome? European Journal of Obstetrics, Gynecology, and Reproductive Biology, 158(2), 254-9. https://doi.org/10.1016/j.ejogrb.2011.06.006
Skałba P, et al. Is the Plasma anti-Müllerian Hormone (AMH) Level Associated With Body Weight and Metabolic, and Hormonal Disturbances in Women With and Without Polycystic Ovary Syndrome. Eur J Obstet Gynecol Reprod Biol. 2011;158(2):254-9. PubMed PMID: 21752527.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is the plasma anti-Müllerian hormone (AMH) level associated with body weight and metabolic, and hormonal disturbances in women with and without polycystic ovary syndrome? AU - Skałba,Piotr, AU - Cygal,Anna, AU - Madej,Paweł, AU - Dąbkowska-Huć,Anna, AU - Sikora,Jerzy, AU - Martirosian,Gayane, AU - Romanik,Małgorzata, AU - Olszanecka-Glinianowicz,Magdalena, Y1 - 2011/07/12/ PY - 2011/02/12/received PY - 2011/04/28/revised PY - 2011/06/09/accepted PY - 2011/7/15/entrez PY - 2011/7/15/pubmed PY - 2012/3/16/medline SP - 254 EP - 9 JF - European journal of obstetrics, gynecology, and reproductive biology JO - Eur J Obstet Gynecol Reprod Biol VL - 158 IS - 2 N2 - OBJECTIVE: The aim of the study was to analyze interrelation between AMH levels and body weight, metabolic, and hormonal status in normal and overweight weight women with and without polycystic ovary syndrome (PCOS). STUDY DESIGN: Eighty-seven women (54 normal weight and 33 overweight) diagnosed with PCOS and 50 apparently healthy women - Non-PCOS (28 normal weight and 22 overweight) were enrolled. The body weight and height were measured and BMI was calculated. In addition to serum glucose, lipids, androgens, FSH, LH, SHBG and insulin, AMH were assessed in fasting state and free androgens index (FAI) was calculated. The insulin resistance was assessed based on the homeostasis model of assessment-insulin resistance (HOMA-IR). RESULTS: Plasma AMH levels were similar in normal weight and overweight PCOS groups (9.6±3.5 vs. 11.2±4.5ng/mL, respectively), and as expected markedly higher than in both Non-PCOS groups (2.5±0.8 and 2.3±0.7ng/mL, respectively). There were no correlations between BMI and AMH levels in all study groups. A significant positive correlation between HOMA-IR, free testosterone concentrations or FAI and AMH levels were found (R=0.31, p<0.001; R=0.91, p<0.001 and R=0.62, p<0.001, respectively). Moreover, there was positive correlation between total or LDL cholesterol and AMH levels (R=0.22, p<0.05 and R=0.31, p<0.05, respectively) and a negative one between HDL cholesterol and AMH levels (R=-0.17, p<0.05) in all study subjects. CONCLUSIONS: The plasma AMH level is associated with insulin resistance but not with BMI per se. Increased circulating AMH level seems to reflect the disturbances of gonadotrophins release in PCOS. It seems that AMH level may be used not only as new surrogate marker of ovarian hyperandrogenism in PCOS but also as a potential new cardiovascular risk factor. SN - 1872-7654 UR - https://www.unboundmedicine.com/medline/citation/21752527/Is_the_plasma_anti_Müllerian_hormone__AMH__level_associated_with_body_weight_and_metabolic_and_hormonal_disturbances_in_women_with_and_without_polycystic_ovary_syndrome L2 - https://linkinghub.elsevier.com/retrieve/pii/S0301-2115(11)00364-2 DB - PRIME DP - Unbound Medicine ER -