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Sleep disturbances associated with gastro-oesophageal reflux disease: prevalence and impact of treatment in French primary care patients.

Abstract

AIM

To evaluate the prevalence of sleep disturbances in French patients with gastro-oesophageal reflux disease and the impact of gastro-oesophageal reflux disease treatment on sleep.

METHODS

A registry was compiled of all gastro-oesophageal reflux disease patients seen during a 2-week period by 1983 French primary care physicians. Data from the first two patients with nocturnal gastro-oesophageal reflux disease symptoms and gastro-oesophageal reflux disease-related sleep disturbances seen by each physician were derived from physician questionnaires and medical records. These patients completed a questionnaire during the initial consultation and after 1-month treatment.

RESULTS

A total of 33,391 patients were included in the study: physician questionnaires were available for 3269 patients and patient questionnaires for 2876. Nocturnal gastro-oesophageal reflux disease symptoms were reported by 21,337 patients (63.9%) and regular (at least once weekly) gastro-oesophageal reflux disease-related sleep disturbances by 19,313 (61.7%). Multivariate analysis showed that nocturnal gastro-oesophageal reflux disease symptoms, use of hypnotic drugs, and age over 50 years were significant independent predictors of sleep disturbances. The proportion of patients reporting at least one nocturnal gastro-oesophageal reflux disease symptom during the previous week decreased following treatment, from 98.8% to 39.3% (P<0.001).

CONCLUSIONS

Nocturnal gastro-oesophageal reflux disease symptoms are common in the French population and are associated with sleep disturbances. Effective treatment can significantly improve sleep duration and quality.

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  • Authors+Show Affiliations

    ,

    Service d'Hépato-Gastro-entérologie, CHU Robert Debré, Rue du Général Koenig, Reims Cedex, France. gcadiot@chu-reims.fr

    , , ,

    Source

    MeSH

    Adult
    Age Factors
    Alginates
    Antacids
    Female
    France
    Gastroesophageal Reflux
    Histamine H2 Antagonists
    Humans
    Hypnotics and Sedatives
    Male
    Middle Aged
    Multivariate Analysis
    Prevalence
    Primary Health Care
    Proton Pump Inhibitors
    Sleep Wake Disorders
    Statistics, Nonparametric
    Surveys and Questionnaires
    Treatment Outcome

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    21752736

    Citation

    Cadiot, Guillaume, et al. "Sleep Disturbances Associated With Gastro-oesophageal Reflux Disease: Prevalence and Impact of Treatment in French Primary Care Patients." Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, vol. 43, no. 10, 2011, pp. 784-7.
    Cadiot G, Delaage PH, Fabry C, et al. Sleep disturbances associated with gastro-oesophageal reflux disease: prevalence and impact of treatment in French primary care patients. Dig Liver Dis. 2011;43(10):784-7.
    Cadiot, G., Delaage, P. H., Fabry, C., Soufflet, C., & Barthélemy, P. (2011). Sleep disturbances associated with gastro-oesophageal reflux disease: prevalence and impact of treatment in French primary care patients. Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 43(10), pp. 784-7. doi:10.1016/j.dld.2011.06.004.
    Cadiot G, et al. Sleep Disturbances Associated With Gastro-oesophageal Reflux Disease: Prevalence and Impact of Treatment in French Primary Care Patients. Dig Liver Dis. 2011;43(10):784-7. PubMed PMID: 21752736.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Sleep disturbances associated with gastro-oesophageal reflux disease: prevalence and impact of treatment in French primary care patients. AU - Cadiot,Guillaume, AU - Delaage,Pierre-Henri, AU - Fabry,Caroline, AU - Soufflet,Christine, AU - Barthélemy,Philippe, Y1 - 2011/07/12/ PY - 2010/07/15/received PY - 2011/05/27/revised PY - 2011/06/02/accepted PY - 2011/7/15/entrez PY - 2011/7/15/pubmed PY - 2012/2/4/medline SP - 784 EP - 7 JF - Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver JO - Dig Liver Dis VL - 43 IS - 10 N2 - AIM: To evaluate the prevalence of sleep disturbances in French patients with gastro-oesophageal reflux disease and the impact of gastro-oesophageal reflux disease treatment on sleep. METHODS: A registry was compiled of all gastro-oesophageal reflux disease patients seen during a 2-week period by 1983 French primary care physicians. Data from the first two patients with nocturnal gastro-oesophageal reflux disease symptoms and gastro-oesophageal reflux disease-related sleep disturbances seen by each physician were derived from physician questionnaires and medical records. These patients completed a questionnaire during the initial consultation and after 1-month treatment. RESULTS: A total of 33,391 patients were included in the study: physician questionnaires were available for 3269 patients and patient questionnaires for 2876. Nocturnal gastro-oesophageal reflux disease symptoms were reported by 21,337 patients (63.9%) and regular (at least once weekly) gastro-oesophageal reflux disease-related sleep disturbances by 19,313 (61.7%). Multivariate analysis showed that nocturnal gastro-oesophageal reflux disease symptoms, use of hypnotic drugs, and age over 50 years were significant independent predictors of sleep disturbances. The proportion of patients reporting at least one nocturnal gastro-oesophageal reflux disease symptom during the previous week decreased following treatment, from 98.8% to 39.3% (P<0.001). CONCLUSIONS: Nocturnal gastro-oesophageal reflux disease symptoms are common in the French population and are associated with sleep disturbances. Effective treatment can significantly improve sleep duration and quality. SN - 1878-3562 UR - https://www.unboundmedicine.com/medline/citation/21752736/Sleep_disturbances_associated_with_gastro_oesophageal_reflux_disease:_prevalence_and_impact_of_treatment_in_French_primary_care_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1590-8658(11)00218-0 DB - PRIME DP - Unbound Medicine ER -