Tags

Type your tag names separated by a space and hit enter

A high intake of trans fatty acids has little effect on markers of inflammation and oxidative stress in humans.

Abstract

Consumption of industrial trans fatty acids (iTFA) increases LDL cholesterol, decreases HDL cholesterol, and is strongly associated with a higher risk of cardiovascular disease (CVD). However, changes in circulating cholesterol cannot explain the entire effect. Therefore, we studied whether iTFA and conjugated linoleic acid (CLA) affect markers of inflammation and oxidative stress. Sixty-one healthy adults consumed each of 3 diets for 3 wk, in random order. Diets were identical except for 7% of energy provided by oleic acid (control diet), iTFA, or CLA. At the end of the 3 wk, we measured plasma inflammatory markers IL-6, C-reactive protein, tumor necrosis factor receptors I and II (TNF-RI and -RII), monocyte chemotactic protein-1 and E-selectin, and urinary 8-iso-PGF(2α), a marker of lipid peroxidation. Consumption of iTFA caused 4% lower TNF-RI concentrations and 6% higher E-selectin concentrations compared with oleic acid (control) and had no significant effect on other inflammatory markers. CLA did not significantly affect inflammatory markers. The urine concentration of 8-iso-PGF(2α) [geometric mean (95% CI)] was greater after the iTFA [0.54 (0.48, 0.60) nmol/mmol creatinine] and the CLA [1.2 (1.1, 1.3) nmol/mmol creatinine] diet periods than after the control period [0.45 (0.41, 0.50) nmol/mmol creatinine; P < 0.05]. In conclusion, high intakes of iTFA and CLA did not substantially affect plasma concentrations of inflammatory markers, but they increased the urine 8-iso-PGF(2α) concentration. However, it is unlikely this plays a major role in the mechanism by which iTFA increase the risk of CVD. However, more research is needed to fully understand the implications of these findings.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Health Sciences and the EMGO Institute for Health and Care Research, Faculty of Earth and Life Sciences, VU University, Amsterdam, The Netherlands.

    , , ,

    Source

    The Journal of nutrition 141:9 2011 Sep pg 1673-8

    MeSH

    Adolescent
    Adult
    Biomarkers
    Cross-Over Studies
    Dietary Fats
    Female
    Humans
    Inflammation
    Male
    Middle Aged
    Oxidative Stress
    Trans Fatty Acids
    Young Adult

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21753062

    Citation

    Smit, Liesbeth A., et al. "A High Intake of Trans Fatty Acids Has Little Effect On Markers of Inflammation and Oxidative Stress in Humans." The Journal of Nutrition, vol. 141, no. 9, 2011, pp. 1673-8.
    Smit LA, Katan MB, Wanders AJ, et al. A high intake of trans fatty acids has little effect on markers of inflammation and oxidative stress in humans. J Nutr. 2011;141(9):1673-8.
    Smit, L. A., Katan, M. B., Wanders, A. J., Basu, S., & Brouwer, I. A. (2011). A high intake of trans fatty acids has little effect on markers of inflammation and oxidative stress in humans. The Journal of Nutrition, 141(9), pp. 1673-8. doi:10.3945/jn.110.134668.
    Smit LA, et al. A High Intake of Trans Fatty Acids Has Little Effect On Markers of Inflammation and Oxidative Stress in Humans. J Nutr. 2011;141(9):1673-8. PubMed PMID: 21753062.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A high intake of trans fatty acids has little effect on markers of inflammation and oxidative stress in humans. AU - Smit,Liesbeth A, AU - Katan,Martijn B, AU - Wanders,Anne J, AU - Basu,Samar, AU - Brouwer,Ingeborg A, Y1 - 2011/07/13/ PY - 2011/7/15/entrez PY - 2011/7/15/pubmed PY - 2011/11/2/medline SP - 1673 EP - 8 JF - The Journal of nutrition JO - J. Nutr. VL - 141 IS - 9 N2 - Consumption of industrial trans fatty acids (iTFA) increases LDL cholesterol, decreases HDL cholesterol, and is strongly associated with a higher risk of cardiovascular disease (CVD). However, changes in circulating cholesterol cannot explain the entire effect. Therefore, we studied whether iTFA and conjugated linoleic acid (CLA) affect markers of inflammation and oxidative stress. Sixty-one healthy adults consumed each of 3 diets for 3 wk, in random order. Diets were identical except for 7% of energy provided by oleic acid (control diet), iTFA, or CLA. At the end of the 3 wk, we measured plasma inflammatory markers IL-6, C-reactive protein, tumor necrosis factor receptors I and II (TNF-RI and -RII), monocyte chemotactic protein-1 and E-selectin, and urinary 8-iso-PGF(2α), a marker of lipid peroxidation. Consumption of iTFA caused 4% lower TNF-RI concentrations and 6% higher E-selectin concentrations compared with oleic acid (control) and had no significant effect on other inflammatory markers. CLA did not significantly affect inflammatory markers. The urine concentration of 8-iso-PGF(2α) [geometric mean (95% CI)] was greater after the iTFA [0.54 (0.48, 0.60) nmol/mmol creatinine] and the CLA [1.2 (1.1, 1.3) nmol/mmol creatinine] diet periods than after the control period [0.45 (0.41, 0.50) nmol/mmol creatinine; P < 0.05]. In conclusion, high intakes of iTFA and CLA did not substantially affect plasma concentrations of inflammatory markers, but they increased the urine 8-iso-PGF(2α) concentration. However, it is unlikely this plays a major role in the mechanism by which iTFA increase the risk of CVD. However, more research is needed to fully understand the implications of these findings. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/21753062/A_high_intake_of_trans_fatty_acids_has_little_effect_on_markers_of_inflammation_and_oxidative_stress_in_humans_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.110.134668 DB - PRIME DP - Unbound Medicine ER -