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Electrophysiological features of Hirayama disease.
Muscle Nerve. 2011 Aug; 44(2):185-90.MN

Abstract

INTRODUCTION

The purpose of this study was to compare the pattern of hand muscle involvement in Hirayama disease (HD) and amyotrophic lateral sclerosis (ALS).

METHODS

We reviewed findings of upper limb nerve conduction studies of 46 HD patients and 60 ALS patients. The findings from 54 healthy subjects were used for comparison.

RESULTS

In HD, the ulnar compound muscle action potential (CMAP) amplitude was more severely reduced than the median one, and the reverse pattern was observed in ALS. The mean ulnar/median (U/M) CMAP amplitude ratio was significantly lower in HD (0.64 ± 0.79) and abnormally higher in ALS (2.15 ± 1.77) compared with normal subjects (0.89 ± 0.23). An abnormally low U/M CMAP amplitude ratio (<0.6) was encountered in 34 patients with HD and in 1 with ALS. A U/M CMAP amplitude ratio ≥4.5 or absent median motor response was found only in ALS.

CONCLUSION

Our findings demonstrate different patterns of hand muscle involvement between these two diseases.

Authors+Show Affiliations

Section of Neuromuscular Disease, Department of Neurology, Chang Gung Memorial Hospital and University Medical College, Linkou Medical Center, No. 5, Fushing Street, Gueishan Township, Taoyuan County, Taoyuan 33305, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21755506

Citation

Lyu, Rong-Kuo, et al. "Electrophysiological Features of Hirayama Disease." Muscle & Nerve, vol. 44, no. 2, 2011, pp. 185-90.
Lyu RK, Huang YC, Wu YR, et al. Electrophysiological features of Hirayama disease. Muscle Nerve. 2011;44(2):185-90.
Lyu, R. K., Huang, Y. C., Wu, Y. R., Kuo, H. C., Ro, L. S., Chen, C. M., & Chang, H. S. (2011). Electrophysiological features of Hirayama disease. Muscle & Nerve, 44(2), 185-90. https://doi.org/10.1002/mus.22028
Lyu RK, et al. Electrophysiological Features of Hirayama Disease. Muscle Nerve. 2011;44(2):185-90. PubMed PMID: 21755506.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Electrophysiological features of Hirayama disease. AU - Lyu,Rong-Kuo, AU - Huang,Ying-Chih, AU - Wu,Yih-Ru, AU - Kuo,Hung-Chou, AU - Ro,Long-Sun, AU - Chen,Chiung-Mei, AU - Chang,Hong-Shiu, PY - 2011/7/15/entrez PY - 2011/7/15/pubmed PY - 2011/9/13/medline SP - 185 EP - 90 JF - Muscle & nerve JO - Muscle Nerve VL - 44 IS - 2 N2 - INTRODUCTION: The purpose of this study was to compare the pattern of hand muscle involvement in Hirayama disease (HD) and amyotrophic lateral sclerosis (ALS). METHODS: We reviewed findings of upper limb nerve conduction studies of 46 HD patients and 60 ALS patients. The findings from 54 healthy subjects were used for comparison. RESULTS: In HD, the ulnar compound muscle action potential (CMAP) amplitude was more severely reduced than the median one, and the reverse pattern was observed in ALS. The mean ulnar/median (U/M) CMAP amplitude ratio was significantly lower in HD (0.64 ± 0.79) and abnormally higher in ALS (2.15 ± 1.77) compared with normal subjects (0.89 ± 0.23). An abnormally low U/M CMAP amplitude ratio (<0.6) was encountered in 34 patients with HD and in 1 with ALS. A U/M CMAP amplitude ratio ≥4.5 or absent median motor response was found only in ALS. CONCLUSION: Our findings demonstrate different patterns of hand muscle involvement between these two diseases. SN - 1097-4598 UR - https://www.unboundmedicine.com/medline/citation/21755506/Electrophysiological_features_of_Hirayama_disease_ L2 - https://doi.org/10.1002/mus.22028 DB - PRIME DP - Unbound Medicine ER -