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Protective effect of Acorus calamus L. in rat model of vincristine induced painful neuropathy: an evidence of anti-inflammatory and anti-oxidative activity.
Food Chem Toxicol. 2011 Oct; 49(10):2557-63.FC

Abstract

The study investigates the protective effect of Acorus calamus L. (AC) in vincristine-induced painful neuropathy. Vincristine (75μg/kg, i.p. for 10 consecutive days) was administered to induce painful neuropathy in rats. Various tests were performed to assess the degree of painful neuropathy at different days i.e., 0, 1, 7, 14, and 21st day. Sciatic nerve TNF-α, superoxide anion generation, total calcium, and myeloperoxidase activity level were also estimated after 21st day of study. Hydro-alcoholic extract of AC (HAE-AC, 100 and 200mg/kg, p.o.) and pregabalin (10mg/kg, p.o.) were administered for 14 consecutive days. Vincristine significantly induced neuropathic pain manifested in the terms of thermal hyperalgesia and allodynia (increase in hind paw licking, lifting or jumping from hot plate); mechanical hyperalgesia (increase in left hind paw lifting duration in pin-prick test) and allodynia (left hind paw withdrawal reflexes to non-noxious stimuli in Von Frey test); and sciatic functional index (analysis of footprints of the feet) along with rise in the levels of various biochemicals. HAE-AC attenuated vincristine induced behavioral, and biochemical changes comparable to that of pregabalin (positive control). HAE-AC attenuated vincristine induced painful neuropathy, which may be attributed to its multiple effects including anti-oxidative, anti-inflammatory, and calcium inhibitory actions.

Authors+Show Affiliations

Pharmacology Division, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, Punjab, India. muthuraman8@gmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21756962

Citation

Muthuraman, Arunachalam, et al. "Protective Effect of Acorus Calamus L. in Rat Model of Vincristine Induced Painful Neuropathy: an Evidence of Anti-inflammatory and Anti-oxidative Activity." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 49, no. 10, 2011, pp. 2557-63.
Muthuraman A, Singh N, Jaggi AS. Protective effect of Acorus calamus L. in rat model of vincristine induced painful neuropathy: an evidence of anti-inflammatory and anti-oxidative activity. Food Chem Toxicol. 2011;49(10):2557-63.
Muthuraman, A., Singh, N., & Jaggi, A. S. (2011). Protective effect of Acorus calamus L. in rat model of vincristine induced painful neuropathy: an evidence of anti-inflammatory and anti-oxidative activity. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 49(10), 2557-63. https://doi.org/10.1016/j.fct.2011.06.069
Muthuraman A, Singh N, Jaggi AS. Protective Effect of Acorus Calamus L. in Rat Model of Vincristine Induced Painful Neuropathy: an Evidence of Anti-inflammatory and Anti-oxidative Activity. Food Chem Toxicol. 2011;49(10):2557-63. PubMed PMID: 21756962.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effect of Acorus calamus L. in rat model of vincristine induced painful neuropathy: an evidence of anti-inflammatory and anti-oxidative activity. AU - Muthuraman,Arunachalam, AU - Singh,Nirmal, AU - Jaggi,Amteshwar Singh, Y1 - 2011/07/03/ PY - 2011/02/22/received PY - 2011/06/20/revised PY - 2011/06/26/accepted PY - 2011/7/16/entrez PY - 2011/7/16/pubmed PY - 2012/2/23/medline SP - 2557 EP - 63 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 49 IS - 10 N2 - The study investigates the protective effect of Acorus calamus L. (AC) in vincristine-induced painful neuropathy. Vincristine (75μg/kg, i.p. for 10 consecutive days) was administered to induce painful neuropathy in rats. Various tests were performed to assess the degree of painful neuropathy at different days i.e., 0, 1, 7, 14, and 21st day. Sciatic nerve TNF-α, superoxide anion generation, total calcium, and myeloperoxidase activity level were also estimated after 21st day of study. Hydro-alcoholic extract of AC (HAE-AC, 100 and 200mg/kg, p.o.) and pregabalin (10mg/kg, p.o.) were administered for 14 consecutive days. Vincristine significantly induced neuropathic pain manifested in the terms of thermal hyperalgesia and allodynia (increase in hind paw licking, lifting or jumping from hot plate); mechanical hyperalgesia (increase in left hind paw lifting duration in pin-prick test) and allodynia (left hind paw withdrawal reflexes to non-noxious stimuli in Von Frey test); and sciatic functional index (analysis of footprints of the feet) along with rise in the levels of various biochemicals. HAE-AC attenuated vincristine induced behavioral, and biochemical changes comparable to that of pregabalin (positive control). HAE-AC attenuated vincristine induced painful neuropathy, which may be attributed to its multiple effects including anti-oxidative, anti-inflammatory, and calcium inhibitory actions. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/21756962/Protective_effect_of_Acorus_calamus_L__in_rat_model_of_vincristine_induced_painful_neuropathy:_an_evidence_of_anti_inflammatory_and_anti_oxidative_activity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(11)00313-9 DB - PRIME DP - Unbound Medicine ER -