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Preliminary study of a traditional Chinese medicine formula in systemic lupus erythematosus patients to taper steroid dose and prevent disease flare-up.
Kaohsiung J Med Sci 2011; 27(7):251-7KJ

Abstract

Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease. Prolonged complete remission is rare. Most patients with SLE need long-term treatment with glucocorticoid and immunomodulators. However, side effects because of the above medications are common. We evaluated the effect of adding-on Dan-Chi-Liu-Wei combination (DCLWC) on SLE patients with conventional therapy in tapering steroid and preventing disease flare-up. This was a double-blind and randomized controlled trial. Sixty-six SLE patients were recruited into this study and 53 patients who fulfilled the 1997 revised criteria for the classification of SLE with an SLE disease activity index (SLEDAI) score of 2-12 and a steroid (measured with prednisolone) daily dose of less than 20mg/d were enrolled. The patients were randomized into either an experimental or control group. We checked the urine analysis, hemogram, liver function, renal function, C3, C4, erythrocyte sedimentation rate, and anti-dsDNA, evaluated the SLEDAI score, and recorded the steroid dose at 0 months, 3 months, and 6 months, respectively. After 6 months of study, the C4 and blood urea nitrogen level revealed a statistically significant difference in either group. There was a tendency toward a decreased SLEDAI score in the experimental group (p=0.083) but not in the control group (p=0.867). The steroid dose was not statistically significant in either group. Renal function and liver function revealed no statistically significant statistics changes in either group. Adding-on DCLWC to conventional therapy for the treatment of SLE was safe and might have a borderline effect in decreasing disease activity, but it was not possible to taper the dosage of steroid after 6 months of clinical trial. Therefore, a long-term follow-up and a large-scale study are necessary to confirm the effect of DCLWC.

Authors+Show Affiliations

Division of Chinese Internal Medicine, Department of Chinese Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21757141

Citation

Liao, Yen-Nung, et al. "Preliminary Study of a Traditional Chinese Medicine Formula in Systemic Lupus Erythematosus Patients to Taper Steroid Dose and Prevent Disease Flare-up." The Kaohsiung Journal of Medical Sciences, vol. 27, no. 7, 2011, pp. 251-7.
Liao YN, Liu CS, Tsai TR, et al. Preliminary study of a traditional Chinese medicine formula in systemic lupus erythematosus patients to taper steroid dose and prevent disease flare-up. Kaohsiung J Med Sci. 2011;27(7):251-7.
Liao, Y. N., Liu, C. S., Tsai, T. R., Hung, Y. C., Chang, S. J., Lin, H. L., ... Chen, C. J. (2011). Preliminary study of a traditional Chinese medicine formula in systemic lupus erythematosus patients to taper steroid dose and prevent disease flare-up. The Kaohsiung Journal of Medical Sciences, 27(7), pp. 251-7. doi:10.1016/j.kjms.2011.03.001.
Liao YN, et al. Preliminary Study of a Traditional Chinese Medicine Formula in Systemic Lupus Erythematosus Patients to Taper Steroid Dose and Prevent Disease Flare-up. Kaohsiung J Med Sci. 2011;27(7):251-7. PubMed PMID: 21757141.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preliminary study of a traditional Chinese medicine formula in systemic lupus erythematosus patients to taper steroid dose and prevent disease flare-up. AU - Liao,Yen-Nung, AU - Liu,Ching-Shen, AU - Tsai,Tong-Rong, AU - Hung,Yu-Chiang, AU - Chang,Shun-Jen, AU - Lin,Hong-Long, AU - Chen,Ying-Chou, AU - Lai,Han-Ming, AU - Yu,Shan-Fu, AU - Chen,Chung-Jen, Y1 - 2011/04/29/ PY - 2010/10/13/received PY - 2011/01/26/accepted PY - 2011/7/16/entrez PY - 2011/7/16/pubmed PY - 2011/11/8/medline SP - 251 EP - 7 JF - The Kaohsiung journal of medical sciences JO - Kaohsiung J. Med. Sci. VL - 27 IS - 7 N2 - Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease. Prolonged complete remission is rare. Most patients with SLE need long-term treatment with glucocorticoid and immunomodulators. However, side effects because of the above medications are common. We evaluated the effect of adding-on Dan-Chi-Liu-Wei combination (DCLWC) on SLE patients with conventional therapy in tapering steroid and preventing disease flare-up. This was a double-blind and randomized controlled trial. Sixty-six SLE patients were recruited into this study and 53 patients who fulfilled the 1997 revised criteria for the classification of SLE with an SLE disease activity index (SLEDAI) score of 2-12 and a steroid (measured with prednisolone) daily dose of less than 20mg/d were enrolled. The patients were randomized into either an experimental or control group. We checked the urine analysis, hemogram, liver function, renal function, C3, C4, erythrocyte sedimentation rate, and anti-dsDNA, evaluated the SLEDAI score, and recorded the steroid dose at 0 months, 3 months, and 6 months, respectively. After 6 months of study, the C4 and blood urea nitrogen level revealed a statistically significant difference in either group. There was a tendency toward a decreased SLEDAI score in the experimental group (p=0.083) but not in the control group (p=0.867). The steroid dose was not statistically significant in either group. Renal function and liver function revealed no statistically significant statistics changes in either group. Adding-on DCLWC to conventional therapy for the treatment of SLE was safe and might have a borderline effect in decreasing disease activity, but it was not possible to taper the dosage of steroid after 6 months of clinical trial. Therefore, a long-term follow-up and a large-scale study are necessary to confirm the effect of DCLWC. SN - 2410-8650 UR - https://www.unboundmedicine.com/medline/citation/21757141/Preliminary_study_of_a_traditional_Chinese_medicine_formula_in_systemic_lupus_erythematosus_patients_to_taper_steroid_dose_and_prevent_disease_flare_up_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1607-551X(11)00075-1 DB - PRIME DP - Unbound Medicine ER -