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Subthalamic local field beta oscillations during ongoing deep brain stimulation in Parkinson's disease in hyperacute and chronic phases.
Neurosignals. 2011; 19(3):151-62.N

Abstract

In the past years, local field potential (LFP) signals recorded from the subthalamic nucleus (STN) in patients undergoing deep brain stimulation (DBS) for Parkinson's disease (PD) disclosed that DBS has a controversial effect on STN beta oscillations recorded 2-7 days after surgery for macroelectrode implantation. Nothing is known about these DBS-induced oscillatory changes 30 days after surgery. We recorded STN LFPs during ongoing DBS in 7 patients with PD, immediately (hyperacute phase) and 30 days (chronic phase) after surgery. STN LFP recordings showed stationary intranuclear STN beta LFP activity in hyperacute and chronic phases, confirming that beta peaks were also present in chronic recordings. Power spectra of nuclei with significant beta activity (54% of the sample) showed that it decreased significantly during DBS (p=0.021) under both recording conditions. The time course of beta activity showed more evident DBS-induced changes in the chronic than in the hyperacute phase (p=0.014). DBS-induced changes in STN beta LFPs in patients undergoing DBS in chronic phase provide useful information for developing a new neurosignal-controlled adaptive DBS system.

Authors+Show Affiliations

Centro Clinico per la Neurostimolazione, le Neurotecnologie ed i Disordini del Movimento, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milano, Italia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21757872

Citation

Rosa, Manuela, et al. "Subthalamic Local Field Beta Oscillations During Ongoing Deep Brain Stimulation in Parkinson's Disease in Hyperacute and Chronic Phases." Neuro-Signals, vol. 19, no. 3, 2011, pp. 151-62.
Rosa M, Giannicola G, Servello D, et al. Subthalamic local field beta oscillations during ongoing deep brain stimulation in Parkinson's disease in hyperacute and chronic phases. Neurosignals. 2011;19(3):151-62.
Rosa, M., Giannicola, G., Servello, D., Marceglia, S., Pacchetti, C., Porta, M., Sassi, M., Scelzo, E., Barbieri, S., & Priori, A. (2011). Subthalamic local field beta oscillations during ongoing deep brain stimulation in Parkinson's disease in hyperacute and chronic phases. Neuro-Signals, 19(3), 151-62. https://doi.org/10.1159/000328508
Rosa M, et al. Subthalamic Local Field Beta Oscillations During Ongoing Deep Brain Stimulation in Parkinson's Disease in Hyperacute and Chronic Phases. Neurosignals. 2011;19(3):151-62. PubMed PMID: 21757872.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Subthalamic local field beta oscillations during ongoing deep brain stimulation in Parkinson's disease in hyperacute and chronic phases. AU - Rosa,Manuela, AU - Giannicola,Gaia, AU - Servello,Domenico, AU - Marceglia,Sara, AU - Pacchetti,Claudio, AU - Porta,Mauro, AU - Sassi,Marco, AU - Scelzo,Emma, AU - Barbieri,Sergio, AU - Priori,Alberto, Y1 - 2011/07/12/ PY - 2010/12/22/received PY - 2011/04/04/accepted PY - 2011/7/16/entrez PY - 2011/7/16/pubmed PY - 2012/1/11/medline SP - 151 EP - 62 JF - Neuro-Signals JO - Neurosignals VL - 19 IS - 3 N2 - In the past years, local field potential (LFP) signals recorded from the subthalamic nucleus (STN) in patients undergoing deep brain stimulation (DBS) for Parkinson's disease (PD) disclosed that DBS has a controversial effect on STN beta oscillations recorded 2-7 days after surgery for macroelectrode implantation. Nothing is known about these DBS-induced oscillatory changes 30 days after surgery. We recorded STN LFPs during ongoing DBS in 7 patients with PD, immediately (hyperacute phase) and 30 days (chronic phase) after surgery. STN LFP recordings showed stationary intranuclear STN beta LFP activity in hyperacute and chronic phases, confirming that beta peaks were also present in chronic recordings. Power spectra of nuclei with significant beta activity (54% of the sample) showed that it decreased significantly during DBS (p=0.021) under both recording conditions. The time course of beta activity showed more evident DBS-induced changes in the chronic than in the hyperacute phase (p=0.014). DBS-induced changes in STN beta LFPs in patients undergoing DBS in chronic phase provide useful information for developing a new neurosignal-controlled adaptive DBS system. SN - 1424-8638 UR - https://www.unboundmedicine.com/medline/citation/21757872/Subthalamic_local_field_beta_oscillations_during_ongoing_deep_brain_stimulation_in_Parkinson's_disease_in_hyperacute_and_chronic_phases_ L2 - https://www.karger.com?DOI=10.1159/000328508 DB - PRIME DP - Unbound Medicine ER -