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Efficacy of flour fortification with folic acid in women of childbearing age in Iran.
Ann Nutr Metab 2011; 58(3):188-96AN

Abstract

BACKGROUND

Flour fortification with folic acid is one of the main strategies for improving folate status in women of childbearing age. No interventional trial on the efficacy of folic acid fortification has been conducted so far in Iran.

OBJECTIVES

To study the effects of flour fortification with folic acid on any reduction in neural tube defects (NTDs) and folate status of women of childbearing age.

METHODS

In a longitudinal hospital-based study, 13,361 postpartum women were studied after admission for childbirth before and after fortification. In addition, two cross-sectional surveys were conducted before (2006) and after flour fortification (2008). The cluster sampling method was used and 580 women, 15-49 years old, were studied as a representative sample of Golestan province in the north of Iran. Fasting blood samples were collected to measure serum vitamin B(12), folate and plasma homocysteine. Sociodemographic data, health characteristics and dietary intake were determined.

RESULTS

The mean daily intakes of folate from natural food before and after flour fortification were 198.3 and 200.8 μg/day, respectively. The total folate intake increased significantly from 198.3 to 413.7 μg/day after fortification (p < 0.001). Folate intake increased by an average of 226 μg/day from fortified bread. The mean serum folate level increased from 13.6 to 18.1 nmol/l; folate deficiency decreased from 14.3 to 2.3% (p < 0.001). The incidence rate of NTDs declined by 31% (p < 0.01) in the post-fortification period (2.19 per 1,000 births; December 2007 to December 2008) compared to the pre-fortification period (3.16 per 1,000 births; September 2006 to July 2007).

CONCLUSIONS

Implementation of mandatory flour fortification with folic acid can lead to a significant increase in serum folate and a significant decrease in NTDs.

Authors+Show Affiliations

Nutrition Department, Ministry of Health and Medical Education, Tehran University of Medical Science, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21757892

Citation

Abdollahi, Z, et al. "Efficacy of Flour Fortification With Folic Acid in Women of Childbearing Age in Iran." Annals of Nutrition & Metabolism, vol. 58, no. 3, 2011, pp. 188-96.
Abdollahi Z, Elmadfa I, Djazayery A, et al. Efficacy of flour fortification with folic acid in women of childbearing age in Iran. Ann Nutr Metab. 2011;58(3):188-96.
Abdollahi, Z., Elmadfa, I., Djazayery, A., Golalipour, M. J., Sadighi, J., Salehi, F., & Sadeghian Sharif, S. (2011). Efficacy of flour fortification with folic acid in women of childbearing age in Iran. Annals of Nutrition & Metabolism, 58(3), pp. 188-96. doi:10.1159/000329726.
Abdollahi Z, et al. Efficacy of Flour Fortification With Folic Acid in Women of Childbearing Age in Iran. Ann Nutr Metab. 2011;58(3):188-96. PubMed PMID: 21757892.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of flour fortification with folic acid in women of childbearing age in Iran. AU - Abdollahi,Z, AU - Elmadfa,I, AU - Djazayery,A, AU - Golalipour,M J, AU - Sadighi,J, AU - Salehi,F, AU - Sadeghian Sharif,S, Y1 - 2011/07/09/ PY - 2010/04/08/received PY - 2011/05/30/accepted PY - 2011/7/16/entrez PY - 2011/7/16/pubmed PY - 2011/12/23/medline SP - 188 EP - 96 JF - Annals of nutrition & metabolism JO - Ann. Nutr. Metab. VL - 58 IS - 3 N2 - BACKGROUND: Flour fortification with folic acid is one of the main strategies for improving folate status in women of childbearing age. No interventional trial on the efficacy of folic acid fortification has been conducted so far in Iran. OBJECTIVES: To study the effects of flour fortification with folic acid on any reduction in neural tube defects (NTDs) and folate status of women of childbearing age. METHODS: In a longitudinal hospital-based study, 13,361 postpartum women were studied after admission for childbirth before and after fortification. In addition, two cross-sectional surveys were conducted before (2006) and after flour fortification (2008). The cluster sampling method was used and 580 women, 15-49 years old, were studied as a representative sample of Golestan province in the north of Iran. Fasting blood samples were collected to measure serum vitamin B(12), folate and plasma homocysteine. Sociodemographic data, health characteristics and dietary intake were determined. RESULTS: The mean daily intakes of folate from natural food before and after flour fortification were 198.3 and 200.8 μg/day, respectively. The total folate intake increased significantly from 198.3 to 413.7 μg/day after fortification (p < 0.001). Folate intake increased by an average of 226 μg/day from fortified bread. The mean serum folate level increased from 13.6 to 18.1 nmol/l; folate deficiency decreased from 14.3 to 2.3% (p < 0.001). The incidence rate of NTDs declined by 31% (p < 0.01) in the post-fortification period (2.19 per 1,000 births; December 2007 to December 2008) compared to the pre-fortification period (3.16 per 1,000 births; September 2006 to July 2007). CONCLUSIONS: Implementation of mandatory flour fortification with folic acid can lead to a significant increase in serum folate and a significant decrease in NTDs. SN - 1421-9697 UR - https://www.unboundmedicine.com/medline/citation/21757892/Efficacy_of_flour_fortification_with_folic_acid_in_women_of_childbearing_age_in_Iran_ L2 - https://www.karger.com?DOI=10.1159/000329726 DB - PRIME DP - Unbound Medicine ER -