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Elevated serum uric acid predicts chronic kidney disease.
Am J Med Sci. 2011 Dec; 342(6):461-6.AJ

Abstract

INTRODUCTION

The question of whether elevated serum uric acid is an independent risk factor for chronic kidney disease in a longitudinal manner was assessed in Japanese subjects undergoing a health checkup.

METHODS

A total of 14,399 participants (8,161 men and 6,238 women) without medication for hyperuremia in both 2000 and 2005 were included. After exclusion of participants taking treatments influencing serum uric acid and having chronic kidney disease defined as estimated glomerular filtration rate <60 mL/min/1.73 m(2), in 2000, multiple logistic regression analyses were performed for 6,887 men (48.4 ± 9.9 years) and 5,340 women (49.9 ± 9.0 years) to identify independent factors for newly diagnosed chronic kidney disease in 2005. Adjustment was made for age, body mass index, elevated blood pressure or hypertension, hypertriglyceridemia, impaired fasting glucose, either urinary protein or occult blood, alcohol drinking and smoking.

RESULTS

The prevalence of chronic kidney disease and the values of body mass index, systolic and diastolic blood pressure and triglyceride were significantly higher in the participants with elevated serum uric acid quartiles. Chronic kidney disease was newly diagnosed in 4.1% of men and 3.7% of women, within the 5-year period. In multivariate models, the higher quartiles of serum uric acid were associated with increased risk of chronic kidney disease in both sexes. The odds ratio and 95% confidence interval for 1 increment of serum uric acid were 1.42 and 1.28 to 1.58 in men and 1.32 and 1.12 to 1.56 in women, respectively.

CONCLUSIONS

Elevated serum uric acid predicts chronic kidney disease in subjects undergoing a health checkup.

Authors+Show Affiliations

Okazaki City Medical Association, Public Health Center, Aichi, Japan. t-yamada@okazaki-med.or.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21760479

Citation

Yamada, Tamaki, et al. "Elevated Serum Uric Acid Predicts Chronic Kidney Disease." The American Journal of the Medical Sciences, vol. 342, no. 6, 2011, pp. 461-6.
Yamada T, Fukatsu M, Suzuki S, et al. Elevated serum uric acid predicts chronic kidney disease. Am J Med Sci. 2011;342(6):461-6.
Yamada, T., Fukatsu, M., Suzuki, S., Wada, T., & Joh, T. (2011). Elevated serum uric acid predicts chronic kidney disease. The American Journal of the Medical Sciences, 342(6), 461-6. https://doi.org/10.1097/MAJ.0b013e318218bd89
Yamada T, et al. Elevated Serum Uric Acid Predicts Chronic Kidney Disease. Am J Med Sci. 2011;342(6):461-6. PubMed PMID: 21760479.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elevated serum uric acid predicts chronic kidney disease. AU - Yamada,Tamaki, AU - Fukatsu,Mitsuru, AU - Suzuki,Sadao, AU - Wada,Tsuneya, AU - Joh,Takashi, PY - 2011/7/16/entrez PY - 2011/7/16/pubmed PY - 2012/1/27/medline SP - 461 EP - 6 JF - The American journal of the medical sciences JO - Am J Med Sci VL - 342 IS - 6 N2 - INTRODUCTION: The question of whether elevated serum uric acid is an independent risk factor for chronic kidney disease in a longitudinal manner was assessed in Japanese subjects undergoing a health checkup. METHODS: A total of 14,399 participants (8,161 men and 6,238 women) without medication for hyperuremia in both 2000 and 2005 were included. After exclusion of participants taking treatments influencing serum uric acid and having chronic kidney disease defined as estimated glomerular filtration rate <60 mL/min/1.73 m(2), in 2000, multiple logistic regression analyses were performed for 6,887 men (48.4 ± 9.9 years) and 5,340 women (49.9 ± 9.0 years) to identify independent factors for newly diagnosed chronic kidney disease in 2005. Adjustment was made for age, body mass index, elevated blood pressure or hypertension, hypertriglyceridemia, impaired fasting glucose, either urinary protein or occult blood, alcohol drinking and smoking. RESULTS: The prevalence of chronic kidney disease and the values of body mass index, systolic and diastolic blood pressure and triglyceride were significantly higher in the participants with elevated serum uric acid quartiles. Chronic kidney disease was newly diagnosed in 4.1% of men and 3.7% of women, within the 5-year period. In multivariate models, the higher quartiles of serum uric acid were associated with increased risk of chronic kidney disease in both sexes. The odds ratio and 95% confidence interval for 1 increment of serum uric acid were 1.42 and 1.28 to 1.58 in men and 1.32 and 1.12 to 1.56 in women, respectively. CONCLUSIONS: Elevated serum uric acid predicts chronic kidney disease in subjects undergoing a health checkup. SN - 1538-2990 UR - https://www.unboundmedicine.com/medline/citation/21760479/Elevated_serum_uric_acid_predicts_chronic_kidney_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9629(15)31101-0 DB - PRIME DP - Unbound Medicine ER -