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Effects of linoleic and gamma-linolenic acids (efamol evening primrose oil) on fatty acid-binding proteins of rat liver.
Mol Cell Biochem 1990 Oct 15-Nov 8; 98(1-2):177-82MC

Abstract

We have studied the effects of Efamol evening primrose oil (EPO) on fatty acid-binding proteins (L-FABP) of rat liver. EPO contains 72% cis-linoleic acid and 9% cis-gamma linolenic acid. EPO has been clinically used for treatment of a number of diseases in humans and animals. EPO is also known to lower cholesterol level in humans and animals. Feeding of an EPO supplemented diet to rats (n = 9) for 2 months decreases the oleate binding capacity of purified L-FABP of rat liver whereas the palmitate binding activity was increased by 38%. However, EPO feeding did not alter the L-FABP concentrations significantly as measured by using the fluorescence fatty acid probe, dansylamino undecanoic acid. Endogenous fatty acid analysis of L-FABPs revealed significant qualitative and quantitative changes in fatty acid pattern after EPO feeding. EPO feeding decreased the endogenous palmitate level by 53% and oleate level by 64% in L-FABPs and also EPO feeding decreased the total endogenous fatty acid content from 62 nanomole per mg of protein to 42 nanomole per mg of L-FABP (n = 3).

Authors+Show Affiliations

Efamol Research Institute, Kentville, Nova Scotia, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2176271

Citation

Dutta-Roy, A K., et al. "Effects of Linoleic and Gamma-linolenic Acids (efamol Evening Primrose Oil) On Fatty Acid-binding Proteins of Rat Liver." Molecular and Cellular Biochemistry, vol. 98, no. 1-2, 1990, pp. 177-82.
Dutta-Roy AK, Demarco AC, Raha SK, et al. Effects of linoleic and gamma-linolenic acids (efamol evening primrose oil) on fatty acid-binding proteins of rat liver. Mol Cell Biochem. 1990;98(1-2):177-82.
Dutta-Roy, A. K., Demarco, A. C., Raha, S. K., Shay, J., Garvey, M., & Horrobin, D. F. (1990). Effects of linoleic and gamma-linolenic acids (efamol evening primrose oil) on fatty acid-binding proteins of rat liver. Molecular and Cellular Biochemistry, 98(1-2), pp. 177-82.
Dutta-Roy AK, et al. Effects of Linoleic and Gamma-linolenic Acids (efamol Evening Primrose Oil) On Fatty Acid-binding Proteins of Rat Liver. Mol Cell Biochem. 1990;98(1-2):177-82. PubMed PMID: 2176271.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of linoleic and gamma-linolenic acids (efamol evening primrose oil) on fatty acid-binding proteins of rat liver. AU - Dutta-Roy,A K, AU - Demarco,A C, AU - Raha,S K, AU - Shay,J, AU - Garvey,M, AU - Horrobin,D F, PY - 1990/10/8/pubmed PY - 1990/10/8/medline PY - 1990/10/8/entrez SP - 177 EP - 82 JF - Molecular and cellular biochemistry JO - Mol. Cell. Biochem. VL - 98 IS - 1-2 N2 - We have studied the effects of Efamol evening primrose oil (EPO) on fatty acid-binding proteins (L-FABP) of rat liver. EPO contains 72% cis-linoleic acid and 9% cis-gamma linolenic acid. EPO has been clinically used for treatment of a number of diseases in humans and animals. EPO is also known to lower cholesterol level in humans and animals. Feeding of an EPO supplemented diet to rats (n = 9) for 2 months decreases the oleate binding capacity of purified L-FABP of rat liver whereas the palmitate binding activity was increased by 38%. However, EPO feeding did not alter the L-FABP concentrations significantly as measured by using the fluorescence fatty acid probe, dansylamino undecanoic acid. Endogenous fatty acid analysis of L-FABPs revealed significant qualitative and quantitative changes in fatty acid pattern after EPO feeding. EPO feeding decreased the endogenous palmitate level by 53% and oleate level by 64% in L-FABPs and also EPO feeding decreased the total endogenous fatty acid content from 62 nanomole per mg of protein to 42 nanomole per mg of L-FABP (n = 3). SN - 0300-8177 UR - https://www.unboundmedicine.com/medline/citation/2176271/Effects_of_linoleic_and_gamma_linolenic_acids__efamol_evening_primrose_oil__on_fatty_acid_binding_proteins_of_rat_liver_ DB - PRIME DP - Unbound Medicine ER -