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A modified formulation of Chinese traditional medicine improves memory impairment and reduces Aβ level in the Tg-APPswe/PS1dE9 mouse model of Alzheimer's disease.
J Ethnopharmacol. 2011 Sep 01; 137(1):783-9.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

SuHeXiang Wan (SHXW), a Chinese traditional medicine has been used orally for the treatment of seizures, infantile convulsion, stroke and so forth. Previously, we reported the effects of modified SHXW essential oil mixture of the fragrance containing herbs on the sedative effect, anticonvulsant property and antioxidative activity after fragrance inhalation.

MATERIALS AND METHODS

This study was undertaken to evaluate beneficial effects of a modified recipe of SHXW (termed as KSOP1009) consisting of a ethanol extract of 8 herbs including resin of Liquidambar orientalis Miller, seed of Myristica fragrans Houtt., rhizome of Cnidium officinale Makino, lumber of Santalum album L., fructus of Piper longum L., flower buds of Eugenia caryophyllata Merrill et Perry, pollen of Typha orientalis Presl., and root of Salvia miltiorrhiza Bunge in the neurodegenerative diseases such as Alzheimer's disease (AD). The transgenic mice of AD, Tg-APPswe/PS1dE9, were fed KSOP1009 or as a positive control, donepezil for 3 months from 4.5 months of age. Behavioral, immunological and ELISA analyses were used to assess memory impairment, Aβ accumulation and plaque deposition in the brain. Other in vitro works were performed to examine whether KSOP1009 inhibits the Aβ(1-42)-induced neurotoxicity in human neuroblastoma cell line, SH-SY5Y cells.

RESULTS

Intake of KSOP1009 improved the Aβ-induced memory impairment and suppressed Aβ levels and plaque deposition in the brain of Tg-APPswe/PS1dE9 mice as much as that of donepezil treatment. KSOP1009 prevented the down-regulation of phospho-CREB and increased AKT phosphorylation in the AD-like brains. Moreover, KSOP1009 suppresses Aβ-induced apoptosis and ROS production in SH-SY5Y cells.

CONCLUSION

The present study suggests that KSOP1009 may develop as a therapeutic drug for treatment of AD patients.

Authors+Show Affiliations

Dongguk University Research Institute of Biotechnology, 26, 3-GA, Pil-dong, Chung-gu, Seoul 100-715, Republic of Korea. jsong0304@dongguk.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21762767

Citation

Jeon, Songhee, et al. "A Modified Formulation of Chinese Traditional Medicine Improves Memory Impairment and Reduces Aβ Level in the Tg-APPswe/PS1dE9 Mouse Model of Alzheimer's Disease." Journal of Ethnopharmacology, vol. 137, no. 1, 2011, pp. 783-9.
Jeon S, Bose S, Hur J, et al. A modified formulation of Chinese traditional medicine improves memory impairment and reduces Aβ level in the Tg-APPswe/PS1dE9 mouse model of Alzheimer's disease. J Ethnopharmacol. 2011;137(1):783-9.
Jeon, S., Bose, S., Hur, J., Jun, K., Kim, Y. K., Cho, K. S., & Koo, B. S. (2011). A modified formulation of Chinese traditional medicine improves memory impairment and reduces Aβ level in the Tg-APPswe/PS1dE9 mouse model of Alzheimer's disease. Journal of Ethnopharmacology, 137(1), 783-9. https://doi.org/10.1016/j.jep.2011.06.046
Jeon S, et al. A Modified Formulation of Chinese Traditional Medicine Improves Memory Impairment and Reduces Aβ Level in the Tg-APPswe/PS1dE9 Mouse Model of Alzheimer's Disease. J Ethnopharmacol. 2011 Sep 1;137(1):783-9. PubMed PMID: 21762767.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A modified formulation of Chinese traditional medicine improves memory impairment and reduces Aβ level in the Tg-APPswe/PS1dE9 mouse model of Alzheimer's disease. AU - Jeon,Songhee, AU - Bose,Shambhunath, AU - Hur,Jinyoung, AU - Jun,Kiyoung, AU - Kim,Young-Kyoon, AU - Cho,Kyoung Sang, AU - Koo,Byung-Soo, Y1 - 2011/07/05/ PY - 2011/02/12/received PY - 2011/06/20/revised PY - 2011/06/28/accepted PY - 2011/7/19/entrez PY - 2011/7/19/pubmed PY - 2011/12/28/medline SP - 783 EP - 9 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 137 IS - 1 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: SuHeXiang Wan (SHXW), a Chinese traditional medicine has been used orally for the treatment of seizures, infantile convulsion, stroke and so forth. Previously, we reported the effects of modified SHXW essential oil mixture of the fragrance containing herbs on the sedative effect, anticonvulsant property and antioxidative activity after fragrance inhalation. MATERIALS AND METHODS: This study was undertaken to evaluate beneficial effects of a modified recipe of SHXW (termed as KSOP1009) consisting of a ethanol extract of 8 herbs including resin of Liquidambar orientalis Miller, seed of Myristica fragrans Houtt., rhizome of Cnidium officinale Makino, lumber of Santalum album L., fructus of Piper longum L., flower buds of Eugenia caryophyllata Merrill et Perry, pollen of Typha orientalis Presl., and root of Salvia miltiorrhiza Bunge in the neurodegenerative diseases such as Alzheimer's disease (AD). The transgenic mice of AD, Tg-APPswe/PS1dE9, were fed KSOP1009 or as a positive control, donepezil for 3 months from 4.5 months of age. Behavioral, immunological and ELISA analyses were used to assess memory impairment, Aβ accumulation and plaque deposition in the brain. Other in vitro works were performed to examine whether KSOP1009 inhibits the Aβ(1-42)-induced neurotoxicity in human neuroblastoma cell line, SH-SY5Y cells. RESULTS: Intake of KSOP1009 improved the Aβ-induced memory impairment and suppressed Aβ levels and plaque deposition in the brain of Tg-APPswe/PS1dE9 mice as much as that of donepezil treatment. KSOP1009 prevented the down-regulation of phospho-CREB and increased AKT phosphorylation in the AD-like brains. Moreover, KSOP1009 suppresses Aβ-induced apoptosis and ROS production in SH-SY5Y cells. CONCLUSION: The present study suggests that KSOP1009 may develop as a therapeutic drug for treatment of AD patients. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/21762767/A_modified_formulation_of_Chinese_traditional_medicine_improves_memory_impairment_and_reduces_Aβ_level_in_the_Tg_APPswe/PS1dE9_mouse_model_of_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(11)00475-2 DB - PRIME DP - Unbound Medicine ER -