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Vitamin D: evidence for its role as a prognostic factor in multiple sclerosis.
J Neurol Sci 2011; 311(1-2):19-22JN

Abstract

Vitamin D insufficiency has been shown to be associated with increased susceptibility to multiple sclerosis (MS), but until recently, it was unclear if vitamin D status also influences the prognosis of the disease. In experimental autoimmune encephalomyelitis, a mouse model of MS, the administration of vitamin D reduces the severity of the disease. Initial reports in MS of inverse associations between vitamin D levels and disability or relapse rate were encouraging, but the cross-sectional or retrospective study designs limited their interpretability. More recently, studies of pediatric-onset and adult MS have demonstrated that among those with established MS, those with lower vitamin D levels are at higher risk for subsequent relapse. These observational data provide strong support for randomized controlled trials of vitamin D supplementation in MS.

Authors+Show Affiliations

Department of Neurology, Multiple Sclerosis Center, University of California, San Francisco, CA 94117, USA. ellen.mowry@ucsf.edu

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

21762931

Citation

Mowry, Ellen M.. "Vitamin D: Evidence for Its Role as a Prognostic Factor in Multiple Sclerosis." Journal of the Neurological Sciences, vol. 311, no. 1-2, 2011, pp. 19-22.
Mowry EM. Vitamin D: evidence for its role as a prognostic factor in multiple sclerosis. J Neurol Sci. 2011;311(1-2):19-22.
Mowry, E. M. (2011). Vitamin D: evidence for its role as a prognostic factor in multiple sclerosis. Journal of the Neurological Sciences, 311(1-2), pp. 19-22. doi:10.1016/j.jns.2011.06.035.
Mowry EM. Vitamin D: Evidence for Its Role as a Prognostic Factor in Multiple Sclerosis. J Neurol Sci. 2011 Dec 15;311(1-2):19-22. PubMed PMID: 21762931.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D: evidence for its role as a prognostic factor in multiple sclerosis. A1 - Mowry,Ellen M, Y1 - 2011/07/16/ PY - 2011/03/14/received PY - 2011/06/20/accepted PY - 2011/7/19/entrez PY - 2011/7/19/pubmed PY - 2012/9/1/medline SP - 19 EP - 22 JF - Journal of the neurological sciences JO - J. Neurol. Sci. VL - 311 IS - 1-2 N2 - Vitamin D insufficiency has been shown to be associated with increased susceptibility to multiple sclerosis (MS), but until recently, it was unclear if vitamin D status also influences the prognosis of the disease. In experimental autoimmune encephalomyelitis, a mouse model of MS, the administration of vitamin D reduces the severity of the disease. Initial reports in MS of inverse associations between vitamin D levels and disability or relapse rate were encouraging, but the cross-sectional or retrospective study designs limited their interpretability. More recently, studies of pediatric-onset and adult MS have demonstrated that among those with established MS, those with lower vitamin D levels are at higher risk for subsequent relapse. These observational data provide strong support for randomized controlled trials of vitamin D supplementation in MS. SN - 1878-5883 UR - https://www.unboundmedicine.com/medline/citation/21762931/Vitamin_D:_evidence_for_its_role_as_a_prognostic_factor_in_multiple_sclerosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(11)00370-4 DB - PRIME DP - Unbound Medicine ER -