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The association between the ratio of triglyceride to HDL-C and insulin resistance according to waist circumference in a rural Korean population.
Nutr Metab Cardiovasc Dis. 2012 Dec; 22(12):1054-60.NM

Abstract

BACKGROUND AND AIMS

This study aimed to examine the association between an increased ratio of triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) and insulin resistance as well as to investigate the interactive effect of TG/HDL-C and waist circumference on insulin resistance in a rural Korean population.

METHODS AND RESULTS

This study, employing a cross-sectional design, included 8411 participants from the Korean Genomic Rural Cohort Study. Levels of fasting insulin, lipid profiles and anthropometric data were assessed for all participants. Insulin resistance was defined as a value greater than the 75th percentile on the homeostasis model assessment of insulin resistance (HOMA-IR). The TG/HDL-C ratio was positively correlated with waist circumference, total cholesterol, low-density lipoprotein cholesterol (LDL-C), TG and HOMA-IR, and negatively correlated with HDL-C when the calculations were controlled for gender. In comparison with the lowest quartile group of TG/HDL-C (≤1.92 in men, ≤1.63 in women), the odds ratios (ORs) (95% confidence interval) for insulin resistance in the highest quartile group of TG/HDL-C (>4.90 in men, >3.93 in women) were 2.33 (1.72-3.16) in men and 2.16 (1.73-2.71) in women, after adjusting for multiple covariates including waist circumference. Following stratification of waist circumference into quartiles, the effect of TG/HDL-C on insulin resistance remained significant irrespective of the waist circumference quartile.

CONCLUSION

The TG/HDL-C ratio was linearly associated with insulin resistance in a rural Korean cohort independently of waist circumference in both genders, albeit not interactive.

Authors+Show Affiliations

Department of Family Medicine, Wonju College of Medicine, Yonsei University, Wonju City, Gangwon-do 220-710, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21764572

Citation

Kang, H-T, et al. "The Association Between the Ratio of Triglyceride to HDL-C and Insulin Resistance According to Waist Circumference in a Rural Korean Population." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 22, no. 12, 2012, pp. 1054-60.
Kang HT, Yoon JH, Kim JY, et al. The association between the ratio of triglyceride to HDL-C and insulin resistance according to waist circumference in a rural Korean population. Nutr Metab Cardiovasc Dis. 2012;22(12):1054-60.
Kang, H. T., Yoon, J. H., Kim, J. Y., Ahn, S. K., Linton, J. A., Koh, S. B., & Kim, J. K. (2012). The association between the ratio of triglyceride to HDL-C and insulin resistance according to waist circumference in a rural Korean population. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 22(12), 1054-60. https://doi.org/10.1016/j.numecd.2011.01.013
Kang HT, et al. The Association Between the Ratio of Triglyceride to HDL-C and Insulin Resistance According to Waist Circumference in a Rural Korean Population. Nutr Metab Cardiovasc Dis. 2012;22(12):1054-60. PubMed PMID: 21764572.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association between the ratio of triglyceride to HDL-C and insulin resistance according to waist circumference in a rural Korean population. AU - Kang,H-T, AU - Yoon,J-H, AU - Kim,J-Y, AU - Ahn,S-K, AU - Linton,J A, AU - Koh,S-B, AU - Kim,J-K, Y1 - 2011/07/18/ PY - 2010/08/06/received PY - 2011/01/17/revised PY - 2011/01/18/accepted PY - 2011/7/19/entrez PY - 2011/7/19/pubmed PY - 2013/5/15/medline SP - 1054 EP - 60 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 22 IS - 12 N2 - BACKGROUND AND AIMS: This study aimed to examine the association between an increased ratio of triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) and insulin resistance as well as to investigate the interactive effect of TG/HDL-C and waist circumference on insulin resistance in a rural Korean population. METHODS AND RESULTS: This study, employing a cross-sectional design, included 8411 participants from the Korean Genomic Rural Cohort Study. Levels of fasting insulin, lipid profiles and anthropometric data were assessed for all participants. Insulin resistance was defined as a value greater than the 75th percentile on the homeostasis model assessment of insulin resistance (HOMA-IR). The TG/HDL-C ratio was positively correlated with waist circumference, total cholesterol, low-density lipoprotein cholesterol (LDL-C), TG and HOMA-IR, and negatively correlated with HDL-C when the calculations were controlled for gender. In comparison with the lowest quartile group of TG/HDL-C (≤1.92 in men, ≤1.63 in women), the odds ratios (ORs) (95% confidence interval) for insulin resistance in the highest quartile group of TG/HDL-C (>4.90 in men, >3.93 in women) were 2.33 (1.72-3.16) in men and 2.16 (1.73-2.71) in women, after adjusting for multiple covariates including waist circumference. Following stratification of waist circumference into quartiles, the effect of TG/HDL-C on insulin resistance remained significant irrespective of the waist circumference quartile. CONCLUSION: The TG/HDL-C ratio was linearly associated with insulin resistance in a rural Korean cohort independently of waist circumference in both genders, albeit not interactive. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/21764572/The_association_between_the_ratio_of_triglyceride_to_HDL_C_and_insulin_resistance_according_to_waist_circumference_in_a_rural_Korean_population_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(11)00049-4 DB - PRIME DP - Unbound Medicine ER -