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β-Adrenergic receptors in the insular cortex are differentially involved in aversive vs. incidental context memory formation.
Learn Mem. 2011; 18(8):502-7.LM

Abstract

The goal of this research was to determine the effects of β-adrenergic antagonism in the IC before or after inhibitory avoidance (IA) training or context pre-exposure in a latent inhibition protocol. Pretraining intra-IC infusion of the β-adrenergic antagonist propranolol disrupted subsequent IA retention and impaired latent inhibition of IA, but had no effect on formation of memory for an inert context (termed incidental memory). These results indicate that IC β-adrenergic receptors are necessary for memory acquisition of an aversive, but not an inconsequential, context. Nevertheless, subsequent association of a familiar and hitherto inconsequential context with an unconditioned stimulus (US) does require activation of these receptors during its initial acquisition.

Authors+Show Affiliations

Departamento de Neurobiología Conductual y Cognitiva, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus Juriquilla, Querétaro, 96230 Mexico. mirandami@unam.mxNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21764846

Citation

Miranda, María Isabel, et al. "Β-Adrenergic Receptors in the Insular Cortex Are Differentially Involved in Aversive Vs. Incidental Context Memory Formation." Learning & Memory (Cold Spring Harbor, N.Y.), vol. 18, no. 8, 2011, pp. 502-7.
Miranda MI, Sabath E, Nuñez-Jaramillo L, et al. Β-Adrenergic receptors in the insular cortex are differentially involved in aversive vs. incidental context memory formation. Learn Mem. 2011;18(8):502-7.
Miranda, M. I., Sabath, E., Nuñez-Jaramillo, L., & Purón-Sierra, L. (2011). Β-Adrenergic receptors in the insular cortex are differentially involved in aversive vs. incidental context memory formation. Learning & Memory (Cold Spring Harbor, N.Y.), 18(8), 502-7. https://doi.org/10.1101/lm.2126111
Miranda MI, et al. Β-Adrenergic Receptors in the Insular Cortex Are Differentially Involved in Aversive Vs. Incidental Context Memory Formation. Learn Mem. 2011;18(8):502-7. PubMed PMID: 21764846.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - β-Adrenergic receptors in the insular cortex are differentially involved in aversive vs. incidental context memory formation. AU - Miranda,María Isabel, AU - Sabath,Elizabeth, AU - Nuñez-Jaramillo,Luis, AU - Purón-Sierra,Liliana, Y1 - 2011/07/15/ PY - 2011/7/19/entrez PY - 2011/7/19/pubmed PY - 2011/12/13/medline SP - 502 EP - 7 JF - Learning & memory (Cold Spring Harbor, N.Y.) JO - Learn Mem VL - 18 IS - 8 N2 - The goal of this research was to determine the effects of β-adrenergic antagonism in the IC before or after inhibitory avoidance (IA) training or context pre-exposure in a latent inhibition protocol. Pretraining intra-IC infusion of the β-adrenergic antagonist propranolol disrupted subsequent IA retention and impaired latent inhibition of IA, but had no effect on formation of memory for an inert context (termed incidental memory). These results indicate that IC β-adrenergic receptors are necessary for memory acquisition of an aversive, but not an inconsequential, context. Nevertheless, subsequent association of a familiar and hitherto inconsequential context with an unconditioned stimulus (US) does require activation of these receptors during its initial acquisition. SN - 1549-5485 UR - https://www.unboundmedicine.com/medline/citation/21764846/β_Adrenergic_receptors_in_the_insular_cortex_are_differentially_involved_in_aversive_vs__incidental_context_memory_formation_ L2 - https://medlineplus.gov/memory.html DB - PRIME DP - Unbound Medicine ER -