Tags

Type your tag names separated by a space and hit enter

Antagonism at NMDA receptors, but not β-adrenergic receptors, disrupts the reconsolidation of pavlovian conditioned approach and instrumental transfer for ethanol-associated conditioned stimuli.
Psychopharmacology (Berl). 2012 Feb; 219(3):751-61.P

Abstract

RATIONALE

Reconsolidation is the process by which memories require restabilisation following destabilisation at retrieval. Since even old, well-established memories become susceptible to disruption following reactivation, treatments based upon disrupting reconsolidation could provide a novel form of therapy for neuropsychiatric disorders based upon maladaptive memories, such as drug addiction. Pavlovian cues are potent precipitators of relapse to drug-seeking behaviour and influence instrumental drug seeking through at least three psychologically and neurobiologically distinct processes: conditioned reinforcement, conditioned approach (autoshaping) and conditioned motivation (pavlovian-instrumental transfer or PIT). We have previously demonstrated that the reconsolidation of memories underlying the conditioned reinforcing properties of drug cues depends upon NMDA receptor (NMDAR)- and β-adrenergic receptor (βAR)-mediated signalling. However, it is unknown whether the drug cue memory representations underlying conditioned approach and PIT depend upon the same mechanisms.

OBJECTIVES

Using orally self-administered ethanol as a reinforcer in two separate experiments, we investigated whether the reconsolidation of the memories underlying conditioned approach and PIT requires βAR- and NMDAR-dependent neurotransmission.

RESULTS

For ethanol self-administering but non-dependent rats, the memories underlying conditioned approach and PIT for a pavlovian drug cue were disrupted by the administration of the NMDAR antagonist MK-801, but not the administration of the βAR antagonist propranolol, when given in conjunction with memory reactivation.

CONCLUSIONS

As for natural reinforcers, NMDARs are required for the reconsolidation of all aspects of pavlovian drug memories, but βARs are only required for the memory representation underlying conditioned reinforcement. These results indicate the potential utility of treatments based upon disrupting cue-drug memory reconsolidation in preventing relapse.

Authors+Show Affiliations

Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge, CB2 3EB, UK. alm46@cam.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21766171

Citation

Milton, Amy L., et al. "Antagonism at NMDA Receptors, but Not Β-adrenergic Receptors, Disrupts the Reconsolidation of Pavlovian Conditioned Approach and Instrumental Transfer for Ethanol-associated Conditioned Stimuli." Psychopharmacology, vol. 219, no. 3, 2012, pp. 751-61.
Milton AL, Schramm MJ, Wawrzynski JR, et al. Antagonism at NMDA receptors, but not β-adrenergic receptors, disrupts the reconsolidation of pavlovian conditioned approach and instrumental transfer for ethanol-associated conditioned stimuli. Psychopharmacology (Berl). 2012;219(3):751-61.
Milton, A. L., Schramm, M. J., Wawrzynski, J. R., Gore, F., Oikonomou-Mpegeti, F., Wang, N. Q., Samuel, D., Economidou, D., & Everitt, B. J. (2012). Antagonism at NMDA receptors, but not β-adrenergic receptors, disrupts the reconsolidation of pavlovian conditioned approach and instrumental transfer for ethanol-associated conditioned stimuli. Psychopharmacology, 219(3), 751-61. https://doi.org/10.1007/s00213-011-2399-9
Milton AL, et al. Antagonism at NMDA Receptors, but Not Β-adrenergic Receptors, Disrupts the Reconsolidation of Pavlovian Conditioned Approach and Instrumental Transfer for Ethanol-associated Conditioned Stimuli. Psychopharmacology (Berl). 2012;219(3):751-61. PubMed PMID: 21766171.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antagonism at NMDA receptors, but not β-adrenergic receptors, disrupts the reconsolidation of pavlovian conditioned approach and instrumental transfer for ethanol-associated conditioned stimuli. AU - Milton,Amy L, AU - Schramm,Moritz J W, AU - Wawrzynski,James R, AU - Gore,Felicity, AU - Oikonomou-Mpegeti,Faye, AU - Wang,Nancy Q, AU - Samuel,Daniel, AU - Economidou,Daina, AU - Everitt,Barry J, Y1 - 2011/07/16/ PY - 2011/02/11/received PY - 2011/06/23/accepted PY - 2011/7/19/entrez PY - 2011/7/19/pubmed PY - 2012/9/25/medline SP - 751 EP - 61 JF - Psychopharmacology JO - Psychopharmacology (Berl) VL - 219 IS - 3 N2 - RATIONALE: Reconsolidation is the process by which memories require restabilisation following destabilisation at retrieval. Since even old, well-established memories become susceptible to disruption following reactivation, treatments based upon disrupting reconsolidation could provide a novel form of therapy for neuropsychiatric disorders based upon maladaptive memories, such as drug addiction. Pavlovian cues are potent precipitators of relapse to drug-seeking behaviour and influence instrumental drug seeking through at least three psychologically and neurobiologically distinct processes: conditioned reinforcement, conditioned approach (autoshaping) and conditioned motivation (pavlovian-instrumental transfer or PIT). We have previously demonstrated that the reconsolidation of memories underlying the conditioned reinforcing properties of drug cues depends upon NMDA receptor (NMDAR)- and β-adrenergic receptor (βAR)-mediated signalling. However, it is unknown whether the drug cue memory representations underlying conditioned approach and PIT depend upon the same mechanisms. OBJECTIVES: Using orally self-administered ethanol as a reinforcer in two separate experiments, we investigated whether the reconsolidation of the memories underlying conditioned approach and PIT requires βAR- and NMDAR-dependent neurotransmission. RESULTS: For ethanol self-administering but non-dependent rats, the memories underlying conditioned approach and PIT for a pavlovian drug cue were disrupted by the administration of the NMDAR antagonist MK-801, but not the administration of the βAR antagonist propranolol, when given in conjunction with memory reactivation. CONCLUSIONS: As for natural reinforcers, NMDARs are required for the reconsolidation of all aspects of pavlovian drug memories, but βARs are only required for the memory representation underlying conditioned reinforcement. These results indicate the potential utility of treatments based upon disrupting cue-drug memory reconsolidation in preventing relapse. SN - 1432-2072 UR - https://www.unboundmedicine.com/medline/citation/21766171/Antagonism_at_NMDA_receptors_but_not_β_adrenergic_receptors_disrupts_the_reconsolidation_of_pavlovian_conditioned_approach_and_instrumental_transfer_for_ethanol_associated_conditioned_stimuli_ L2 - https://dx.doi.org/10.1007/s00213-011-2399-9 DB - PRIME DP - Unbound Medicine ER -