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Application of a new amidophosphite ligand to Rh-catalyzed asymmetric hydrogenation of β-dehydroamino acid derivatives in supercritical carbon dioxide: activation effect of protic Co-solvents.
Chirality. 2011 Sep; 23(8):624-7.C

Abstract

New chiral amidophosphite ligand was synthesized and tested in the Rh-catalyzed asymmetric hydrogenation of (Z)-β-(acylamino)acrylates in protic solvents and supercritical carbon dioxide (scCO(2)) The catalytic performance is affected greatly by the acidity of the solvents. Better enantioselectivity (up to 88% ee) was achieved in scCO(2) containing 1,1,1,3,3,3-hexafluoro-2-propanol, compared to neat protic solvents.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Lyubimov SE
Institute of Organoelement Compounds, Russian Academy of Sciences, 119991 Moscow, Russia. lssp452@mail.ru
Rastorguev EA
No affiliation info available
Davankov VA
No affiliation info available

MeSH

Amino AcidsCarbon DioxideCatalysisHydrogenationLigandsMolecular StructureOrganophosphorus CompoundsRhodiumSolventsStereoisomerism

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21766342

Citation

Lyubimov, Sergey E., et al. "Application of a New Amidophosphite Ligand to Rh-catalyzed Asymmetric Hydrogenation of Β-dehydroamino Acid Derivatives in Supercritical Carbon Dioxide: Activation Effect of Protic Co-solvents." Chirality, vol. 23, no. 8, 2011, pp. 624-7.
Lyubimov SE, Rastorguev EA, Davankov VA. Application of a new amidophosphite ligand to Rh-catalyzed asymmetric hydrogenation of β-dehydroamino acid derivatives in supercritical carbon dioxide: activation effect of protic Co-solvents. Chirality. 2011;23(8):624-7.
Lyubimov, S. E., Rastorguev, E. A., & Davankov, V. A. (2011). Application of a new amidophosphite ligand to Rh-catalyzed asymmetric hydrogenation of β-dehydroamino acid derivatives in supercritical carbon dioxide: activation effect of protic Co-solvents. Chirality, 23(8), 624-7. https://doi.org/10.1002/chir.20992
Lyubimov SE, Rastorguev EA, Davankov VA. Application of a New Amidophosphite Ligand to Rh-catalyzed Asymmetric Hydrogenation of Β-dehydroamino Acid Derivatives in Supercritical Carbon Dioxide: Activation Effect of Protic Co-solvents. Chirality. 2011;23(8):624-7. PubMed PMID: 21766342.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Application of a new amidophosphite ligand to Rh-catalyzed asymmetric hydrogenation of β-dehydroamino acid derivatives in supercritical carbon dioxide: activation effect of protic Co-solvents. AU - Lyubimov,Sergey E, AU - Rastorguev,Eugenie A, AU - Davankov,Vadim A, Y1 - 2011/07/15/ PY - 2011/03/16/received PY - 2011/05/17/accepted PY - 2011/7/19/entrez PY - 2011/7/19/pubmed PY - 2011/12/21/medline SP - 624 EP - 7 JF - Chirality JO - Chirality VL - 23 IS - 8 N2 - New chiral amidophosphite ligand was synthesized and tested in the Rh-catalyzed asymmetric hydrogenation of (Z)-β-(acylamino)acrylates in protic solvents and supercritical carbon dioxide (scCO(2)) The catalytic performance is affected greatly by the acidity of the solvents. Better enantioselectivity (up to 88% ee) was achieved in scCO(2) containing 1,1,1,3,3,3-hexafluoro-2-propanol, compared to neat protic solvents. SN - 1520-636X UR - https://www.unboundmedicine.com/medline/citation/21766342/Application_of_a_new_amidophosphite_ligand_to_Rh_catalyzed_asymmetric_hydrogenation_of_β_dehydroamino_acid_derivatives_in_supercritical_carbon_dioxide:_activation_effect_of_protic_Co_solvents_ L2 - https://doi.org/10.1002/chir.20992 DB - PRIME DP - Unbound Medicine ER -