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Effectiveness of a MF-59™-adjuvanted pandemic influenza vaccine to prevent 2009 A/H1N1 influenza-related hospitalisation; a matched case-control study.
BMC Infect Dis 2011; 11:196BI

Abstract

BACKGROUND

During the 2009 influenza A/H1N1 pandemic, adjuvanted influenza vaccines were used for the first time on a large scale. Results on the effectiveness of the vaccines in preventing 2009 influenza A/H1N1-related hospitalisation are scanty and varying.

METHODS

We conducted a matched case-control study in individuals with an indication for vaccination due to underlying medical conditions and/or age ≥ 60 years in The Netherlands. Cases were patients hospitalised with laboratory-confirmed 2009 A/H1N1 influenza infection between November 16, 2009 and January 15, 2010. Controls were matched to cases on age, sex and type of underlying medical condition(s) and drawn from an extensive general practitioner network. Conditional logistic regression was used to estimate the vaccine effectiveness (VE = 1 - OR). Different sensitivity analyses were used to assess confounding by severity of underlying medical condition(s) and the effect of different assumptions for missing dates of vaccination.

RESULTS

149 cases and 28,238 matched controls were included. It was estimated that 22% of the cases and 28% of the controls received vaccination more than 7 days before the date of onset of symptoms in cases. A significant number of breakthrough infections were observed. The VE was estimated at 19% (95%CI -28-49). After restricting the analysis to cases with controls suffering from severe underlying medical conditions, the VE was 49% (95% CI 16-69).

CONCLUSIONS

The number of breakthrough infections, resulting in modest VE estimates, suggests that the MF-59™ adjuvanted vaccine may have had only a limited impact on preventing 2009 influenza A/H1N1-related hospitalisation in this setting. As the main aim of influenza vaccination programmes is to reduce severe influenza-related morbidity and mortality from influenza in persons at high risk of complications, a more effective vaccine, or additional preventive measures, are needed.

Authors+Show Affiliations

Epidemiology and Surveillance Unit, Centre for Infectious Disease Control, National institute for Public Health and the Environment, Bilthoven, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21767348

Citation

Steens, Anneke, et al. "Effectiveness of a MF-59™-adjuvanted Pandemic Influenza Vaccine to Prevent 2009 A/H1N1 Influenza-related Hospitalisation; a Matched Case-control Study." BMC Infectious Diseases, vol. 11, 2011, p. 196.
Steens A, Wijnans EG, Dieleman JP, et al. Effectiveness of a MF-59™-adjuvanted pandemic influenza vaccine to prevent 2009 A/H1N1 influenza-related hospitalisation; a matched case-control study. BMC Infect Dis. 2011;11:196.
Steens, A., Wijnans, E. G., Dieleman, J. P., Sturkenboom, M. C., van der Sande, M. A., & van der Hoek, W. (2011). Effectiveness of a MF-59™-adjuvanted pandemic influenza vaccine to prevent 2009 A/H1N1 influenza-related hospitalisation; a matched case-control study. BMC Infectious Diseases, 11, p. 196. doi:10.1186/1471-2334-11-196.
Steens A, et al. Effectiveness of a MF-59™-adjuvanted Pandemic Influenza Vaccine to Prevent 2009 A/H1N1 Influenza-related Hospitalisation; a Matched Case-control Study. BMC Infect Dis. 2011 Jul 18;11:196. PubMed PMID: 21767348.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effectiveness of a MF-59™-adjuvanted pandemic influenza vaccine to prevent 2009 A/H1N1 influenza-related hospitalisation; a matched case-control study. AU - Steens,Anneke, AU - Wijnans,Eleonora G, AU - Dieleman,Jeanne P, AU - Sturkenboom,Miriam Cjm, AU - van der Sande,Marianne Ab, AU - van der Hoek,Wim, Y1 - 2011/07/18/ PY - 2011/01/19/received PY - 2011/07/18/accepted PY - 2011/7/20/entrez PY - 2011/7/20/pubmed PY - 2011/11/4/medline SP - 196 EP - 196 JF - BMC infectious diseases JO - BMC Infect. Dis. VL - 11 N2 - BACKGROUND: During the 2009 influenza A/H1N1 pandemic, adjuvanted influenza vaccines were used for the first time on a large scale. Results on the effectiveness of the vaccines in preventing 2009 influenza A/H1N1-related hospitalisation are scanty and varying. METHODS: We conducted a matched case-control study in individuals with an indication for vaccination due to underlying medical conditions and/or age ≥ 60 years in The Netherlands. Cases were patients hospitalised with laboratory-confirmed 2009 A/H1N1 influenza infection between November 16, 2009 and January 15, 2010. Controls were matched to cases on age, sex and type of underlying medical condition(s) and drawn from an extensive general practitioner network. Conditional logistic regression was used to estimate the vaccine effectiveness (VE = 1 - OR). Different sensitivity analyses were used to assess confounding by severity of underlying medical condition(s) and the effect of different assumptions for missing dates of vaccination. RESULTS: 149 cases and 28,238 matched controls were included. It was estimated that 22% of the cases and 28% of the controls received vaccination more than 7 days before the date of onset of symptoms in cases. A significant number of breakthrough infections were observed. The VE was estimated at 19% (95%CI -28-49). After restricting the analysis to cases with controls suffering from severe underlying medical conditions, the VE was 49% (95% CI 16-69). CONCLUSIONS: The number of breakthrough infections, resulting in modest VE estimates, suggests that the MF-59™ adjuvanted vaccine may have had only a limited impact on preventing 2009 influenza A/H1N1-related hospitalisation in this setting. As the main aim of influenza vaccination programmes is to reduce severe influenza-related morbidity and mortality from influenza in persons at high risk of complications, a more effective vaccine, or additional preventive measures, are needed. SN - 1471-2334 UR - https://www.unboundmedicine.com/medline/citation/21767348/Effectiveness_of_a_MF_59™_adjuvanted_pandemic_influenza_vaccine_to_prevent_2009_A/H1N1_influenza_related_hospitalisation L2 - https://bmcinfectdis.biomedcentral.com/articles/10.1186/1471-2334-11-196 DB - PRIME DP - Unbound Medicine ER -