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The endocannabinoid system in anxiety, fear memory and habituation.
J Psychopharmacol. 2012 Jan; 26(1):23-39.JP

Abstract

Evidence for the involvement of the endocannabinoid system (ECS) in anxiety and fear has been accumulated, providing leads for novel therapeutic approaches. In anxiety, a bidirectional influence of the ECS has been reported, whereby anxiolytic and anxiogenic responses have been obtained after both increases and decreases of the endocannabinoid tone. The recently developed genetic tools have revealed different but complementary roles for the cannabinoid type 1 (CB1) receptor on GABAergic and glutamatergic neuronal populations. This dual functionality, together with the plasticity of CB1 receptor expression, particularly on GABAergic neurons, as induced by stressful and rewarding experiences, gives the ECS a unique regulatory capacity for maintaining emotional homeostasis. However, the promiscuity of the endogenous ligands of the CB1 receptor complicates the interpretation of experimental data concerning ECS and anxiety. In fear memory paradigms, the ECS is mostly involved in the two opposing processes of reconsolidation and extinction of the fear memory. Whereas ECS activation deteriorates reconsolidation, proper extinction depends on intact CB1 receptor signalling. Thus, both for anxiety and fear memory processing, endocannabinoid signalling may ensure an appropriate reaction to stressful events. Therefore, the ECS can be considered as a regulatory buffer system for emotional responses.

Authors+Show Affiliations

Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

21768162

Citation

Ruehle, S, et al. "The Endocannabinoid System in Anxiety, Fear Memory and Habituation." Journal of Psychopharmacology (Oxford, England), vol. 26, no. 1, 2012, pp. 23-39.
Ruehle S, Rey AA, Remmers F, et al. The endocannabinoid system in anxiety, fear memory and habituation. J Psychopharmacol (Oxford). 2012;26(1):23-39.
Ruehle, S., Rey, A. A., Remmers, F., & Lutz, B. (2012). The endocannabinoid system in anxiety, fear memory and habituation. Journal of Psychopharmacology (Oxford, England), 26(1), 23-39. https://doi.org/10.1177/0269881111408958
Ruehle S, et al. The Endocannabinoid System in Anxiety, Fear Memory and Habituation. J Psychopharmacol (Oxford). 2012;26(1):23-39. PubMed PMID: 21768162.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The endocannabinoid system in anxiety, fear memory and habituation. AU - Ruehle,S, AU - Rey,A Aparisi, AU - Remmers,F, AU - Lutz,B, Y1 - 2011/07/18/ PY - 2011/7/20/entrez PY - 2011/7/20/pubmed PY - 2012/8/22/medline SP - 23 EP - 39 JF - Journal of psychopharmacology (Oxford, England) JO - J. Psychopharmacol. (Oxford) VL - 26 IS - 1 N2 - Evidence for the involvement of the endocannabinoid system (ECS) in anxiety and fear has been accumulated, providing leads for novel therapeutic approaches. In anxiety, a bidirectional influence of the ECS has been reported, whereby anxiolytic and anxiogenic responses have been obtained after both increases and decreases of the endocannabinoid tone. The recently developed genetic tools have revealed different but complementary roles for the cannabinoid type 1 (CB1) receptor on GABAergic and glutamatergic neuronal populations. This dual functionality, together with the plasticity of CB1 receptor expression, particularly on GABAergic neurons, as induced by stressful and rewarding experiences, gives the ECS a unique regulatory capacity for maintaining emotional homeostasis. However, the promiscuity of the endogenous ligands of the CB1 receptor complicates the interpretation of experimental data concerning ECS and anxiety. In fear memory paradigms, the ECS is mostly involved in the two opposing processes of reconsolidation and extinction of the fear memory. Whereas ECS activation deteriorates reconsolidation, proper extinction depends on intact CB1 receptor signalling. Thus, both for anxiety and fear memory processing, endocannabinoid signalling may ensure an appropriate reaction to stressful events. Therefore, the ECS can be considered as a regulatory buffer system for emotional responses. SN - 1461-7285 UR - https://www.unboundmedicine.com/medline/citation/21768162/The_endocannabinoid_system_in_anxiety_fear_memory_and_habituation_ L2 - http://journals.sagepub.com/doi/full/10.1177/0269881111408958?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -