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Association of Angiotensin-converting enzyme insertion(I)/deletion (D) genotype in Alzheimer's disease patients of north Indian population.

Abstract

Several lines of evidence support for the role of angiotensin-converting enzyme (ACE) in Alzheimer's disease (AD) patients. Most human genetic studies have focussed on ACE insertion (I)/deletion (D) polymorphism and have yielded conflicting results. We have evaluated the association of ACE polymorphism with serum ACE activity in 95 AD patients and 110 healthy controls from north Indian population. In Alzheimer's patients a higher frequency of D allele was detected (I/D ratio 0.53:0.47) compared with the control group (I/D ratio 0.54:0.45), the difference being not statistically significant (p > .05). AD patients were found to be more homozygous for the D allele (26.3%) compared with controls (20.8%). The observed genotype distribution was in agreement with Hardy-Weinberg equilibrium. We observed that the D/D genotype is more in patients with a higher serum ACE activity. The D allele and the D/D genotype in AD patients may influence increased risk of cognitive impairment.

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  • Authors+Show Affiliations

    ,

    Department of Neurobiochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.

    , , ,

    Source

    MeSH

    Aged
    Aged, 80 and over
    Alzheimer Disease
    Chi-Square Distribution
    Female
    Gene Deletion
    Gene Frequency
    Genetic Association Studies
    Genetic Predisposition to Disease
    Genotype
    Humans
    India
    Male
    Middle Aged
    Peptidyl-Dipeptidase A
    Polymorphism, Genetic

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    21770707

    Citation

    Nirmal, Sonali, et al. "Association of Angiotensin-converting Enzyme insertion(I)/deletion (D) Genotype in Alzheimer's Disease Patients of North Indian Population." The International Journal of Neuroscience, vol. 121, no. 10, 2011, pp. 557-61.
    Nirmal S, Tripathi M, Shastri SS, et al. Association of Angiotensin-converting enzyme insertion(I)/deletion (D) genotype in Alzheimer's disease patients of north Indian population. Int J Neurosci. 2011;121(10):557-61.
    Nirmal, S., Tripathi, M., Shastri, S. S., Sagar, R., & S, V. (2011). Association of Angiotensin-converting enzyme insertion(I)/deletion (D) genotype in Alzheimer's disease patients of north Indian population. The International Journal of Neuroscience, 121(10), pp. 557-61. doi:10.3109/00207454.2011.591513.
    Nirmal S, et al. Association of Angiotensin-converting Enzyme insertion(I)/deletion (D) Genotype in Alzheimer's Disease Patients of North Indian Population. Int J Neurosci. 2011;121(10):557-61. PubMed PMID: 21770707.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association of Angiotensin-converting enzyme insertion(I)/deletion (D) genotype in Alzheimer's disease patients of north Indian population. AU - Nirmal,Sonali, AU - Tripathi,Manjari, AU - Shastri,Shivaram S, AU - Sagar,Rajesh, AU - S,Vivekanandhan, Y1 - 2011/07/19/ PY - 2011/7/21/entrez PY - 2011/7/21/pubmed PY - 2012/1/26/medline SP - 557 EP - 61 JF - The International journal of neuroscience JO - Int. J. Neurosci. VL - 121 IS - 10 N2 - Several lines of evidence support for the role of angiotensin-converting enzyme (ACE) in Alzheimer's disease (AD) patients. Most human genetic studies have focussed on ACE insertion (I)/deletion (D) polymorphism and have yielded conflicting results. We have evaluated the association of ACE polymorphism with serum ACE activity in 95 AD patients and 110 healthy controls from north Indian population. In Alzheimer's patients a higher frequency of D allele was detected (I/D ratio 0.53:0.47) compared with the control group (I/D ratio 0.54:0.45), the difference being not statistically significant (p > .05). AD patients were found to be more homozygous for the D allele (26.3%) compared with controls (20.8%). The observed genotype distribution was in agreement with Hardy-Weinberg equilibrium. We observed that the D/D genotype is more in patients with a higher serum ACE activity. The D allele and the D/D genotype in AD patients may influence increased risk of cognitive impairment. SN - 1563-5279 UR - https://www.unboundmedicine.com/medline/citation/21770707/Association_of_Angiotensin_converting_enzyme_insertion_I_/deletion__D__genotype_in_Alzheimer's_disease_patients_of_north_Indian_population_ L2 - http://www.tandfonline.com/doi/full/10.3109/00207454.2011.591513 DB - PRIME DP - Unbound Medicine ER -