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Association of Angiotensin-converting enzyme insertion(I)/deletion (D) genotype in Alzheimer's disease patients of north Indian population.
Int J Neurosci 2011; 121(10):557-61IJ

Abstract

Several lines of evidence support for the role of angiotensin-converting enzyme (ACE) in Alzheimer's disease (AD) patients. Most human genetic studies have focussed on ACE insertion (I)/deletion (D) polymorphism and have yielded conflicting results. We have evaluated the association of ACE polymorphism with serum ACE activity in 95 AD patients and 110 healthy controls from north Indian population. In Alzheimer's patients a higher frequency of D allele was detected (I/D ratio 0.53:0.47) compared with the control group (I/D ratio 0.54:0.45), the difference being not statistically significant (p > .05). AD patients were found to be more homozygous for the D allele (26.3%) compared with controls (20.8%). The observed genotype distribution was in agreement with Hardy-Weinberg equilibrium. We observed that the D/D genotype is more in patients with a higher serum ACE activity. The D allele and the D/D genotype in AD patients may influence increased risk of cognitive impairment.

Authors+Show Affiliations

Department of Neurobiochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21770707

Citation

Nirmal, Sonali, et al. "Association of Angiotensin-converting Enzyme insertion(I)/deletion (D) Genotype in Alzheimer's Disease Patients of North Indian Population." The International Journal of Neuroscience, vol. 121, no. 10, 2011, pp. 557-61.
Nirmal S, Tripathi M, Shastri SS, et al. Association of Angiotensin-converting enzyme insertion(I)/deletion (D) genotype in Alzheimer's disease patients of north Indian population. Int J Neurosci. 2011;121(10):557-61.
Nirmal, S., Tripathi, M., Shastri, S. S., Sagar, R., & S, V. (2011). Association of Angiotensin-converting enzyme insertion(I)/deletion (D) genotype in Alzheimer's disease patients of north Indian population. The International Journal of Neuroscience, 121(10), pp. 557-61. doi:10.3109/00207454.2011.591513.
Nirmal S, et al. Association of Angiotensin-converting Enzyme insertion(I)/deletion (D) Genotype in Alzheimer's Disease Patients of North Indian Population. Int J Neurosci. 2011;121(10):557-61. PubMed PMID: 21770707.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of Angiotensin-converting enzyme insertion(I)/deletion (D) genotype in Alzheimer's disease patients of north Indian population. AU - Nirmal,Sonali, AU - Tripathi,Manjari, AU - Shastri,Shivaram S, AU - Sagar,Rajesh, AU - S,Vivekanandhan, Y1 - 2011/07/19/ PY - 2011/7/21/entrez PY - 2011/7/21/pubmed PY - 2012/1/26/medline SP - 557 EP - 61 JF - The International journal of neuroscience JO - Int. J. Neurosci. VL - 121 IS - 10 N2 - Several lines of evidence support for the role of angiotensin-converting enzyme (ACE) in Alzheimer's disease (AD) patients. Most human genetic studies have focussed on ACE insertion (I)/deletion (D) polymorphism and have yielded conflicting results. We have evaluated the association of ACE polymorphism with serum ACE activity in 95 AD patients and 110 healthy controls from north Indian population. In Alzheimer's patients a higher frequency of D allele was detected (I/D ratio 0.53:0.47) compared with the control group (I/D ratio 0.54:0.45), the difference being not statistically significant (p > .05). AD patients were found to be more homozygous for the D allele (26.3%) compared with controls (20.8%). The observed genotype distribution was in agreement with Hardy-Weinberg equilibrium. We observed that the D/D genotype is more in patients with a higher serum ACE activity. The D allele and the D/D genotype in AD patients may influence increased risk of cognitive impairment. SN - 1563-5279 UR - https://www.unboundmedicine.com/medline/citation/21770707/Association_of_Angiotensin_converting_enzyme_insertion_I_/deletion__D__genotype_in_Alzheimer's_disease_patients_of_north_Indian_population_ L2 - http://www.tandfonline.com/doi/full/10.3109/00207454.2011.591513 DB - PRIME DP - Unbound Medicine ER -