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Synthesis of novel benzoxanthone analogues as non-Camptothecin topoisomerase I inhibitors.
J Enzyme Inhib Med Chem. 2012 Jun; 27(3):437-42.JE

Abstract

Structure modification of the side chain of the lead compound benzoxanthone provided a series of benzoxanthone analogues and 12 of them were first reported. The results showed that most of these compounds had moderate cytotoxicity against tumour cells with the 50% inhibition concentration in the micromolar range. Furthermore, benzoxanthone derivatives 5, 6c, 7a and 7e, showed potent topoisomerase I (Topo I) inhibitory effect and the results indicated that some compounds had potential for development as non-Camptothecin (CPT) topoisomerase I inhibitors.

Authors+Show Affiliations

School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21770860

Citation

Cheng, Pengfei, et al. "Synthesis of Novel Benzoxanthone Analogues as non-Camptothecin Topoisomerase I Inhibitors." Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 27, no. 3, 2012, pp. 437-42.
Cheng P, Zhu L, Guo W, et al. Synthesis of novel benzoxanthone analogues as non-Camptothecin topoisomerase I inhibitors. J Enzyme Inhib Med Chem. 2012;27(3):437-42.
Cheng, P., Zhu, L., Guo, W., Liu, W., Yao, J., Dong, G., Zhang, Y., Zhuang, C., Sheng, C., Miao, Z., & Zhang, W. (2012). Synthesis of novel benzoxanthone analogues as non-Camptothecin topoisomerase I inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry, 27(3), 437-42. https://doi.org/10.3109/14756366.2011.595712
Cheng P, et al. Synthesis of Novel Benzoxanthone Analogues as non-Camptothecin Topoisomerase I Inhibitors. J Enzyme Inhib Med Chem. 2012;27(3):437-42. PubMed PMID: 21770860.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis of novel benzoxanthone analogues as non-Camptothecin topoisomerase I inhibitors. AU - Cheng,Pengfei, AU - Zhu,Lingjian, AU - Guo,Wei, AU - Liu,Wenfeng, AU - Yao,Jianzhong, AU - Dong,Guoqiang, AU - Zhang,Yongqiang, AU - Zhuang,Chunlin, AU - Sheng,Chunquan, AU - Miao,Zhenyuan, AU - Zhang,Wannian, Y1 - 2011/07/20/ PY - 2011/7/21/entrez PY - 2011/7/21/pubmed PY - 2012/12/10/medline SP - 437 EP - 42 JF - Journal of enzyme inhibition and medicinal chemistry JO - J Enzyme Inhib Med Chem VL - 27 IS - 3 N2 - Structure modification of the side chain of the lead compound benzoxanthone provided a series of benzoxanthone analogues and 12 of them were first reported. The results showed that most of these compounds had moderate cytotoxicity against tumour cells with the 50% inhibition concentration in the micromolar range. Furthermore, benzoxanthone derivatives 5, 6c, 7a and 7e, showed potent topoisomerase I (Topo I) inhibitory effect and the results indicated that some compounds had potential for development as non-Camptothecin (CPT) topoisomerase I inhibitors. SN - 1475-6374 UR - https://www.unboundmedicine.com/medline/citation/21770860/Synthesis_of_novel_benzoxanthone_analogues_as_non_Camptothecin_topoisomerase_I_inhibitors_ L2 - http://www.tandfonline.com/doi/full/10.3109/14756366.2011.595712 DB - PRIME DP - Unbound Medicine ER -