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Onychomycosis in patients with psoriasis--a multicentre study.
Mycoses. 2012 Mar; 55(2):143-7.M

Abstract

1-3% of human population is affected by psoriasis. Nail disorders are reported in 10-80% of patients with psoriasis. Nail deformations vary according to their degree of severity but are mainly represented by pitting, Beau's lines, hyperkeratosis, onycholysis, leuconychia or oil drops. Onychomycosis is a fungal infection of the nails, caused by dermatophytes, yeast and moulds. In this study, 228 patients with psoriasis aged between 18 and 72 were examined (48 - from Plovdiv, Bulgaria; 145 - from Pleven, Bulgaria and 35 - from Thessaloniki, Greece); 145 of them were male and 83 of them were female. The examination of the nail material was performed via direct microscopy with 20% KOH and nail samples plated out on Sabouraud agar methodology. The severity of the nail disorders was determined according to the Nail Psoriasis Severity Index (NAPSI). Positive mycological cultures were obtained from 62% of the patients with psoriasis (52%- Plovdiv, Bulgaria; 70%- Pleven, Bulgaria and 43%- Thessaloniki, Greece). In 67% of the cases, the infection was caused by dermatophytes, in 24% by yeast, in 6% by moulds and in 3% by a combination of causes. All patients with psoriasis were identified with high levels of NAPSI, whereas the ones with isolated Candida had even higher levels. Seventeen percentage of the patients have been treated with methotrexate, 6% have been diagnosed with diabetes and 22% have been reported with onychomycosis and tinea pedis within the family. An increased prevalence of onychomycosis among the patients with psoriasis was found. Dystrophic nails in psoriasis patients are more predisposed to fungal infections. The mycological examination of all psoriasis patients with nail deformations is considered obligatory because of the great number of psoriasis patients diagnosed with onychomycosis.

Authors+Show Affiliations

Dermatology and Venereology, Medical University Plovdiv, Plovdiv, Bulgaria. lzisova@abv.bgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

21771106

Citation

Zisova, L, et al. "Onychomycosis in Patients With Psoriasis--a Multicentre Study." Mycoses, vol. 55, no. 2, 2012, pp. 143-7.
Zisova L, Valtchev V, Sotiriou E, et al. Onychomycosis in patients with psoriasis--a multicentre study. Mycoses. 2012;55(2):143-7.
Zisova, L., Valtchev, V., Sotiriou, E., Gospodinov, D., & Mateev, G. (2012). Onychomycosis in patients with psoriasis--a multicentre study. Mycoses, 55(2), 143-7. https://doi.org/10.1111/j.1439-0507.2011.02053.x
Zisova L, et al. Onychomycosis in Patients With Psoriasis--a Multicentre Study. Mycoses. 2012;55(2):143-7. PubMed PMID: 21771106.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Onychomycosis in patients with psoriasis--a multicentre study. AU - Zisova,L, AU - Valtchev,V, AU - Sotiriou,E, AU - Gospodinov,D, AU - Mateev,G, Y1 - 2011/07/20/ PY - 2011/7/21/entrez PY - 2011/7/21/pubmed PY - 2013/5/3/medline SP - 143 EP - 7 JF - Mycoses JO - Mycoses VL - 55 IS - 2 N2 - 1-3% of human population is affected by psoriasis. Nail disorders are reported in 10-80% of patients with psoriasis. Nail deformations vary according to their degree of severity but are mainly represented by pitting, Beau's lines, hyperkeratosis, onycholysis, leuconychia or oil drops. Onychomycosis is a fungal infection of the nails, caused by dermatophytes, yeast and moulds. In this study, 228 patients with psoriasis aged between 18 and 72 were examined (48 - from Plovdiv, Bulgaria; 145 - from Pleven, Bulgaria and 35 - from Thessaloniki, Greece); 145 of them were male and 83 of them were female. The examination of the nail material was performed via direct microscopy with 20% KOH and nail samples plated out on Sabouraud agar methodology. The severity of the nail disorders was determined according to the Nail Psoriasis Severity Index (NAPSI). Positive mycological cultures were obtained from 62% of the patients with psoriasis (52%- Plovdiv, Bulgaria; 70%- Pleven, Bulgaria and 43%- Thessaloniki, Greece). In 67% of the cases, the infection was caused by dermatophytes, in 24% by yeast, in 6% by moulds and in 3% by a combination of causes. All patients with psoriasis were identified with high levels of NAPSI, whereas the ones with isolated Candida had even higher levels. Seventeen percentage of the patients have been treated with methotrexate, 6% have been diagnosed with diabetes and 22% have been reported with onychomycosis and tinea pedis within the family. An increased prevalence of onychomycosis among the patients with psoriasis was found. Dystrophic nails in psoriasis patients are more predisposed to fungal infections. The mycological examination of all psoriasis patients with nail deformations is considered obligatory because of the great number of psoriasis patients diagnosed with onychomycosis. SN - 1439-0507 UR - https://www.unboundmedicine.com/medline/citation/21771106/Onychomycosis_in_patients_with_psoriasis__a_multicentre_study_ L2 - https://doi.org/10.1111/j.1439-0507.2011.02053.x DB - PRIME DP - Unbound Medicine ER -