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Ovalbumin-specific immunoglobulins A and G levels at age 2 years are associated with the occurrence of atopic disorders.
Clin Exp Allergy. 2011 Oct; 41(10):1414-21.CE

Abstract

BACKGROUND

Humoral responses to food antigens may reflect the propensity of a child's immune system to develop tolerance to innocuous antigens. Early nutrition as well as probiotics may influence these immunological responses.

OBJECTIVE

To study the association of humoral responses to early food antigens with the administration of prebiotics and probiotics, with the occurrence of allergy, and with the length of exclusive breastfeeding.

METHODS

In a randomized double-blind allergy prevention trial in high-risk children, 1018 mothers took probiotics or placebo from the 36th week of gestation, and their newborn infants received probiotics and prebiotics or placebo during 6 months. At 2 and 5 years, we evaluated the cumulative incidence of allergic diseases (food allergy, eczema, asthma, rhinitis) and sensitization (skin prick test ≥3 mm or serum antigen-specific IgE>0.7 kU/L). In 688 infants at age 2, we measured in sera-specific IgA, IgG, IgG1, and IgG4 antibody levels to cow's milk (CM), α-casein (CAS), β-lactoglobulin (BLG), and ovalbumin (OVA) with ELISA, and specific IgE levels to CM and hen's egg with UniCap.

RESULTS

Probiotic treatment (n=342) compared with placebo (n=346) showed no effect on serum food-specific IgA, IgG, IgG1, or IgG4 concentrations at age 2. Atopic children had higher OVA-IgA (P<0.001), OVA-IgG (P=0.001), OVA-IgG1 (P<0.001), and egg-IgE but lower OVA-IgG4/egg-IgE ratio (P<0.001) than non-atopic children. Longer duration of exclusive breastfeeding (≥4 vs. <4 months) was associated with reduced CM- and CAS-specific serum IgA (P<0.001) and IgG levels (P<0.001; P=0.003).

CONCLUSION AND CLINICAL RELEVANCE

Allergy was associated with more intense IgA and IgG responses to OVA. Breastfeeding depressed humoral responses, whereas prebiotics and probiotics supplementation showed no immunomodulatory effect. The effect of probiotics on allergies is not mediated through food-specific antibody responses. Furthermore, OVA-specific IgA and IgG antibodies may help in assessing the risk for atopy.

Authors+Show Affiliations

Skin and Allergy Hospital, University of Helsinki, Helsinki, Finland. kaarina.kukkonen@hus.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21771118

Citation

Kukkonen, A K., et al. "Ovalbumin-specific Immunoglobulins a and G Levels at Age 2 Years Are Associated With the Occurrence of Atopic Disorders." Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 41, no. 10, 2011, pp. 1414-21.
Kukkonen AK, Savilahti EM, Haahtela T, et al. Ovalbumin-specific immunoglobulins A and G levels at age 2 years are associated with the occurrence of atopic disorders. Clin Exp Allergy. 2011;41(10):1414-21.
Kukkonen, A. K., Savilahti, E. M., Haahtela, T., Savilahti, E., & Kuitunen, M. (2011). Ovalbumin-specific immunoglobulins A and G levels at age 2 years are associated with the occurrence of atopic disorders. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 41(10), 1414-21. https://doi.org/10.1111/j.1365-2222.2011.03821.x
Kukkonen AK, et al. Ovalbumin-specific Immunoglobulins a and G Levels at Age 2 Years Are Associated With the Occurrence of Atopic Disorders. Clin Exp Allergy. 2011;41(10):1414-21. PubMed PMID: 21771118.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ovalbumin-specific immunoglobulins A and G levels at age 2 years are associated with the occurrence of atopic disorders. AU - Kukkonen,A K, AU - Savilahti,E M, AU - Haahtela,T, AU - Savilahti,E, AU - Kuitunen,M, Y1 - 2011/07/19/ PY - 2011/7/21/entrez PY - 2011/7/21/pubmed PY - 2012/3/16/medline SP - 1414 EP - 21 JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JO - Clin. Exp. Allergy VL - 41 IS - 10 N2 - BACKGROUND: Humoral responses to food antigens may reflect the propensity of a child's immune system to develop tolerance to innocuous antigens. Early nutrition as well as probiotics may influence these immunological responses. OBJECTIVE: To study the association of humoral responses to early food antigens with the administration of prebiotics and probiotics, with the occurrence of allergy, and with the length of exclusive breastfeeding. METHODS: In a randomized double-blind allergy prevention trial in high-risk children, 1018 mothers took probiotics or placebo from the 36th week of gestation, and their newborn infants received probiotics and prebiotics or placebo during 6 months. At 2 and 5 years, we evaluated the cumulative incidence of allergic diseases (food allergy, eczema, asthma, rhinitis) and sensitization (skin prick test ≥3 mm or serum antigen-specific IgE>0.7 kU/L). In 688 infants at age 2, we measured in sera-specific IgA, IgG, IgG1, and IgG4 antibody levels to cow's milk (CM), α-casein (CAS), β-lactoglobulin (BLG), and ovalbumin (OVA) with ELISA, and specific IgE levels to CM and hen's egg with UniCap. RESULTS: Probiotic treatment (n=342) compared with placebo (n=346) showed no effect on serum food-specific IgA, IgG, IgG1, or IgG4 concentrations at age 2. Atopic children had higher OVA-IgA (P<0.001), OVA-IgG (P=0.001), OVA-IgG1 (P<0.001), and egg-IgE but lower OVA-IgG4/egg-IgE ratio (P<0.001) than non-atopic children. Longer duration of exclusive breastfeeding (≥4 vs. <4 months) was associated with reduced CM- and CAS-specific serum IgA (P<0.001) and IgG levels (P<0.001; P=0.003). CONCLUSION AND CLINICAL RELEVANCE: Allergy was associated with more intense IgA and IgG responses to OVA. Breastfeeding depressed humoral responses, whereas prebiotics and probiotics supplementation showed no immunomodulatory effect. The effect of probiotics on allergies is not mediated through food-specific antibody responses. Furthermore, OVA-specific IgA and IgG antibodies may help in assessing the risk for atopy. SN - 1365-2222 UR - https://www.unboundmedicine.com/medline/citation/21771118/Ovalbumin_specific_immunoglobulins_A_and_G_levels_at_age_2_years_are_associated_with_the_occurrence_of_atopic_disorders_ L2 - https://doi.org/10.1111/j.1365-2222.2011.03821.x DB - PRIME DP - Unbound Medicine ER -