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Impact of consumption of vegetable, fruit, grain, and high glycemic index foods on aggressive prostate cancer risk.
Nutr Cancer 2011; 63(6):860-72NC

Abstract

Prostate cancer is a common but complex disease, and distinguishing modifiable risk factors such as diet for more aggressive disease is extremely important. Previous work has detected intriguing associations between vegetable, fruit, and grains and more aggressive prostate cancer, although these remain somewhat unclear. Here we further investigate such potential relationships with a case-control study of 982 men (470 more aggressive prostate cancer cases and 512 control subjects). Comparing the highest to lowest quartiles of intake, we found that increasing intakes of leafy vegetables were inversely associated with risk of aggressive prostate cancer [adjusted odds ratio (OR) = 0.66, 95% CI: 0.46, 0.96; P trend = 0.02], as was higher consumption of high carotenoid vegetables (OR = 0.71, 95% CI: 0.48, 1.04; P trend = 0.04). Conversely, increased consumption of high glycemic index foods were positively associated with risk of aggressive disease (OR = 1.64, 95% CI: 1.05, 2.57; P trend = 0.02). These results were driven by a number of specific foods within the food groups. Our findings support the hypothesis that diets high in vegetables and low in high glycemic index foods decrease risk of aggressive prostate cancer.

Authors+Show Affiliations

Department of Epidemiology, University of California at San Francisco, San Francisco, California 94158-9001, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

21774611

Citation

Hardin, Jill, et al. "Impact of Consumption of Vegetable, Fruit, Grain, and High Glycemic Index Foods On Aggressive Prostate Cancer Risk." Nutrition and Cancer, vol. 63, no. 6, 2011, pp. 860-72.
Hardin J, Cheng I, Witte JS. Impact of consumption of vegetable, fruit, grain, and high glycemic index foods on aggressive prostate cancer risk. Nutr Cancer. 2011;63(6):860-72.
Hardin, J., Cheng, I., & Witte, J. S. (2011). Impact of consumption of vegetable, fruit, grain, and high glycemic index foods on aggressive prostate cancer risk. Nutrition and Cancer, 63(6), pp. 860-72. doi:10.1080/01635581.2011.582224.
Hardin J, Cheng I, Witte JS. Impact of Consumption of Vegetable, Fruit, Grain, and High Glycemic Index Foods On Aggressive Prostate Cancer Risk. Nutr Cancer. 2011;63(6):860-72. PubMed PMID: 21774611.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of consumption of vegetable, fruit, grain, and high glycemic index foods on aggressive prostate cancer risk. AU - Hardin,Jill, AU - Cheng,Iona, AU - Witte,John S, Y1 - 2011/07/20/ PY - 2011/7/22/entrez PY - 2011/7/22/pubmed PY - 2011/12/28/medline SP - 860 EP - 72 JF - Nutrition and cancer JO - Nutr Cancer VL - 63 IS - 6 N2 - Prostate cancer is a common but complex disease, and distinguishing modifiable risk factors such as diet for more aggressive disease is extremely important. Previous work has detected intriguing associations between vegetable, fruit, and grains and more aggressive prostate cancer, although these remain somewhat unclear. Here we further investigate such potential relationships with a case-control study of 982 men (470 more aggressive prostate cancer cases and 512 control subjects). Comparing the highest to lowest quartiles of intake, we found that increasing intakes of leafy vegetables were inversely associated with risk of aggressive prostate cancer [adjusted odds ratio (OR) = 0.66, 95% CI: 0.46, 0.96; P trend = 0.02], as was higher consumption of high carotenoid vegetables (OR = 0.71, 95% CI: 0.48, 1.04; P trend = 0.04). Conversely, increased consumption of high glycemic index foods were positively associated with risk of aggressive disease (OR = 1.64, 95% CI: 1.05, 2.57; P trend = 0.02). These results were driven by a number of specific foods within the food groups. Our findings support the hypothesis that diets high in vegetables and low in high glycemic index foods decrease risk of aggressive prostate cancer. SN - 1532-7914 UR - https://www.unboundmedicine.com/medline/citation/21774611/Impact_of_consumption_of_vegetable_fruit_grain_and_high_glycemic_index_foods_on_aggressive_prostate_cancer_risk_ L2 - http://www.tandfonline.com/doi/full/10.1080/01635581.2011.582224 DB - PRIME DP - Unbound Medicine ER -