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Impact of consumption of vegetable, fruit, grain, and high glycemic index foods on aggressive prostate cancer risk.

Abstract

Prostate cancer is a common but complex disease, and distinguishing modifiable risk factors such as diet for more aggressive disease is extremely important. Previous work has detected intriguing associations between vegetable, fruit, and grains and more aggressive prostate cancer, although these remain somewhat unclear. Here we further investigate such potential relationships with a case-control study of 982 men (470 more aggressive prostate cancer cases and 512 control subjects). Comparing the highest to lowest quartiles of intake, we found that increasing intakes of leafy vegetables were inversely associated with risk of aggressive prostate cancer [adjusted odds ratio (OR) = 0.66, 95% CI: 0.46, 0.96; P trend = 0.02], as was higher consumption of high carotenoid vegetables (OR = 0.71, 95% CI: 0.48, 1.04; P trend = 0.04). Conversely, increased consumption of high glycemic index foods were positively associated with risk of aggressive disease (OR = 1.64, 95% CI: 1.05, 2.57; P trend = 0.02). These results were driven by a number of specific foods within the food groups. Our findings support the hypothesis that diets high in vegetables and low in high glycemic index foods decrease risk of aggressive prostate cancer.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology, University of California at San Francisco, San Francisco, California 94158-9001, USA.

    ,

    Source

    Nutrition and cancer 63:6 2011 pg 860-72

    MeSH

    Aged
    Carotenoids
    Case-Control Studies
    Data Collection
    Diet
    Edible Grain
    Energy Intake
    Feeding Behavior
    Fruit
    Glycemic Index
    Humans
    Interviews as Topic
    Male
    Middle Aged
    Odds Ratio
    Prostatic Neoplasms
    Risk Factors
    Surveys and Questionnaires
    Vegetables

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    21774611

    Citation

    Hardin, Jill, et al. "Impact of Consumption of Vegetable, Fruit, Grain, and High Glycemic Index Foods On Aggressive Prostate Cancer Risk." Nutrition and Cancer, vol. 63, no. 6, 2011, pp. 860-72.
    Hardin J, Cheng I, Witte JS. Impact of consumption of vegetable, fruit, grain, and high glycemic index foods on aggressive prostate cancer risk. Nutr Cancer. 2011;63(6):860-72.
    Hardin, J., Cheng, I., & Witte, J. S. (2011). Impact of consumption of vegetable, fruit, grain, and high glycemic index foods on aggressive prostate cancer risk. Nutrition and Cancer, 63(6), pp. 860-72. doi:10.1080/01635581.2011.582224.
    Hardin J, Cheng I, Witte JS. Impact of Consumption of Vegetable, Fruit, Grain, and High Glycemic Index Foods On Aggressive Prostate Cancer Risk. Nutr Cancer. 2011;63(6):860-72. PubMed PMID: 21774611.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Impact of consumption of vegetable, fruit, grain, and high glycemic index foods on aggressive prostate cancer risk. AU - Hardin,Jill, AU - Cheng,Iona, AU - Witte,John S, Y1 - 2011/07/20/ PY - 2011/7/22/entrez PY - 2011/7/22/pubmed PY - 2011/12/28/medline SP - 860 EP - 72 JF - Nutrition and cancer JO - Nutr Cancer VL - 63 IS - 6 N2 - Prostate cancer is a common but complex disease, and distinguishing modifiable risk factors such as diet for more aggressive disease is extremely important. Previous work has detected intriguing associations between vegetable, fruit, and grains and more aggressive prostate cancer, although these remain somewhat unclear. Here we further investigate such potential relationships with a case-control study of 982 men (470 more aggressive prostate cancer cases and 512 control subjects). Comparing the highest to lowest quartiles of intake, we found that increasing intakes of leafy vegetables were inversely associated with risk of aggressive prostate cancer [adjusted odds ratio (OR) = 0.66, 95% CI: 0.46, 0.96; P trend = 0.02], as was higher consumption of high carotenoid vegetables (OR = 0.71, 95% CI: 0.48, 1.04; P trend = 0.04). Conversely, increased consumption of high glycemic index foods were positively associated with risk of aggressive disease (OR = 1.64, 95% CI: 1.05, 2.57; P trend = 0.02). These results were driven by a number of specific foods within the food groups. Our findings support the hypothesis that diets high in vegetables and low in high glycemic index foods decrease risk of aggressive prostate cancer. SN - 1532-7914 UR - https://www.unboundmedicine.com/medline/citation/21774611/Impact_of_consumption_of_vegetable_fruit_grain_and_high_glycemic_index_foods_on_aggressive_prostate_cancer_risk_ L2 - http://www.tandfonline.com/doi/full/10.1080/01635581.2011.582224 DB - PRIME DP - Unbound Medicine ER -