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Report on the analysis of common beverages spiked with gamma-hydroxybutyric acid (GHB) and gamma-butyrolactone (GBL) using NMR and the PURGE solvent-suppression technique.
Forensic Sci Int. 2011 Oct 10; 212(1-3):e40-5.FS

Abstract

In forensic evidence, the identification and quantitation of gamma-hydroxybutyric acid (GHB) in "spiked" beverages is challenging. In this report, we present the analysis of common alcoholic beverages found in clubs and bars spiked with gamma-hydroxybutyric acid (GHB) and gamma-butyrolactone (GBL). Our analysis of the spiked beverages consisted of using (1)H NMR with a water suppression method called Presaturation Utilizing Relaxation Gradients and Echoes (PURGE). The following beverages were analyzed: water, 10% ethanol in water, vodka-cranberry juice, rum and coke, gin and tonic, whisky and diet coke, white wine, red wine, and beer. The PURGE method allowed for the direct identification and quantitation of both compounds in all beverages except red and white wine where small interferences prevented accurate quantitation. The NMR method presented in this paper utilizes PURGE water suppression. Thanks to the use of a capillary internal standard, the method is fast, non-destructive, sensitive and requires no sample preparation which could disrupt the equilibrium between GHB and GBL.

Authors+Show Affiliations

Department of Science, John Jay College of Criminal Justice, City University of New York, 445 west 59th Street, New York, NY 10019, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21775083

Citation

Lesar, Casey T., et al. "Report On the Analysis of Common Beverages Spiked With Gamma-hydroxybutyric Acid (GHB) and Gamma-butyrolactone (GBL) Using NMR and the PURGE Solvent-suppression Technique." Forensic Science International, vol. 212, no. 1-3, 2011, pp. e40-5.
Lesar CT, Decatur J, Lukasiewicz E, et al. Report on the analysis of common beverages spiked with gamma-hydroxybutyric acid (GHB) and gamma-butyrolactone (GBL) using NMR and the PURGE solvent-suppression technique. Forensic Sci Int. 2011;212(1-3):e40-5.
Lesar, C. T., Decatur, J., Lukasiewicz, E., & Champeil, E. (2011). Report on the analysis of common beverages spiked with gamma-hydroxybutyric acid (GHB) and gamma-butyrolactone (GBL) using NMR and the PURGE solvent-suppression technique. Forensic Science International, 212(1-3), e40-5. https://doi.org/10.1016/j.forsciint.2011.06.017
Lesar CT, et al. Report On the Analysis of Common Beverages Spiked With Gamma-hydroxybutyric Acid (GHB) and Gamma-butyrolactone (GBL) Using NMR and the PURGE Solvent-suppression Technique. Forensic Sci Int. 2011 Oct 10;212(1-3):e40-5. PubMed PMID: 21775083.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Report on the analysis of common beverages spiked with gamma-hydroxybutyric acid (GHB) and gamma-butyrolactone (GBL) using NMR and the PURGE solvent-suppression technique. AU - Lesar,Casey T, AU - Decatur,John, AU - Lukasiewicz,Elaan, AU - Champeil,Elise, Y1 - 2011/07/20/ PY - 2011/02/21/received PY - 2011/06/16/revised PY - 2011/06/19/accepted PY - 2011/7/22/entrez PY - 2011/7/22/pubmed PY - 2012/2/3/medline SP - e40 EP - 5 JF - Forensic science international JO - Forensic Sci Int VL - 212 IS - 1-3 N2 - In forensic evidence, the identification and quantitation of gamma-hydroxybutyric acid (GHB) in "spiked" beverages is challenging. In this report, we present the analysis of common alcoholic beverages found in clubs and bars spiked with gamma-hydroxybutyric acid (GHB) and gamma-butyrolactone (GBL). Our analysis of the spiked beverages consisted of using (1)H NMR with a water suppression method called Presaturation Utilizing Relaxation Gradients and Echoes (PURGE). The following beverages were analyzed: water, 10% ethanol in water, vodka-cranberry juice, rum and coke, gin and tonic, whisky and diet coke, white wine, red wine, and beer. The PURGE method allowed for the direct identification and quantitation of both compounds in all beverages except red and white wine where small interferences prevented accurate quantitation. The NMR method presented in this paper utilizes PURGE water suppression. Thanks to the use of a capillary internal standard, the method is fast, non-destructive, sensitive and requires no sample preparation which could disrupt the equilibrium between GHB and GBL. SN - 1872-6283 UR - https://www.unboundmedicine.com/medline/citation/21775083/Report_on_the_analysis_of_common_beverages_spiked_with_gamma_hydroxybutyric_acid__GHB__and_gamma_butyrolactone__GBL__using_NMR_and_the_PURGE_solvent_suppression_technique_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0379-0738(11)00298-2 DB - PRIME DP - Unbound Medicine ER -