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Intake of fish oil during pregnancy and adiposity in 19-y-old offspring: follow-up on a randomized controlled trial.

Abstract

BACKGROUND

It is well established that obesity tends to track from early childhood into adult life. Studies in experimental animals have suggested that changes in the peri- and early postnatal intake of n-3 (omega-3) polyunsaturated acids can affect the development of obesity in adult life.

OBJECTIVE

The aim of the current study was to investigate the effect of daily supplementation with 2.7 g long-chain n-3 fatty acids during the third trimester of pregnancy on adiposity in 19-y-old offspring.

DESIGN

The study was based on follow-up of a randomized controlled trial from 1990, in which 533 pregnant women were randomly assigned to receive fish oil, olive oil, or no oil. At ≈19 y of age, the offspring of subjects from the randomized controlled trial were invited to undergo a physical examination, including anthropometric measurements and fasting blood sampling. The blood sample was analyzed for insulin, glucose, glycated hemoglobin, leptin, adiponectin, insulin-like growth factor I, and high-sensitivity C-reactive protein. Multiple linear regression modeling, adjusted for sex, smoking, and parental overweight, was used to estimate the effect of fish oil relative to that of olive oil on BMI (in kg/m(2)), waist circumference, and biochemical measures.

RESULTS

A total of 243 of the offspring were followed up. We found no difference between the fish-oil and olive oil groups in BMI (0.13; -0.92, 1.17) or waist circumference (0.7 cm; -2.1, 3.4 cm). Overall, results of the biochemical analyses supported the finding of no difference between the groups.

CONCLUSION

We detected no effect of fish-oil supplementation during pregnancy on offspring adiposity in adolescence.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology, School of Public Health, Aarhus University, Denmark. dr@soci.au.dk

    , , , ,

    Source

    MeSH

    Adult
    Biomarkers
    Body Mass Index
    Dietary Fats
    Dietary Supplements
    Fatty Acids, Omega-3
    Female
    Fish Oils
    Follow-Up Studies
    Humans
    Male
    Obesity
    Pregnancy
    Pregnancy Trimester, Third
    Prenatal Exposure Delayed Effects
    Prenatal Nutritional Physiological Phenomena
    Waist Circumference
    Young Adult

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21775563

    Citation

    Rytter, Dorte, et al. "Intake of Fish Oil During Pregnancy and Adiposity in 19-y-old Offspring: Follow-up On a Randomized Controlled Trial." The American Journal of Clinical Nutrition, vol. 94, no. 3, 2011, pp. 701-8.
    Rytter D, Bech BH, Christensen JH, et al. Intake of fish oil during pregnancy and adiposity in 19-y-old offspring: follow-up on a randomized controlled trial. Am J Clin Nutr. 2011;94(3):701-8.
    Rytter, D., Bech, B. H., Christensen, J. H., Schmidt, E. B., Henriksen, T. B., & Olsen, S. F. (2011). Intake of fish oil during pregnancy and adiposity in 19-y-old offspring: follow-up on a randomized controlled trial. The American Journal of Clinical Nutrition, 94(3), pp. 701-8. doi:10.3945/ajcn.111.014969.
    Rytter D, et al. Intake of Fish Oil During Pregnancy and Adiposity in 19-y-old Offspring: Follow-up On a Randomized Controlled Trial. Am J Clin Nutr. 2011;94(3):701-8. PubMed PMID: 21775563.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Intake of fish oil during pregnancy and adiposity in 19-y-old offspring: follow-up on a randomized controlled trial. AU - Rytter,Dorte, AU - Bech,Bodil H, AU - Christensen,Jeppe H, AU - Schmidt,Erik B, AU - Henriksen,Tine B, AU - Olsen,Sjurdur F, Y1 - 2011/07/20/ PY - 2011/7/22/entrez PY - 2011/7/22/pubmed PY - 2011/11/1/medline SP - 701 EP - 8 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 94 IS - 3 N2 - BACKGROUND: It is well established that obesity tends to track from early childhood into adult life. Studies in experimental animals have suggested that changes in the peri- and early postnatal intake of n-3 (omega-3) polyunsaturated acids can affect the development of obesity in adult life. OBJECTIVE: The aim of the current study was to investigate the effect of daily supplementation with 2.7 g long-chain n-3 fatty acids during the third trimester of pregnancy on adiposity in 19-y-old offspring. DESIGN: The study was based on follow-up of a randomized controlled trial from 1990, in which 533 pregnant women were randomly assigned to receive fish oil, olive oil, or no oil. At ≈19 y of age, the offspring of subjects from the randomized controlled trial were invited to undergo a physical examination, including anthropometric measurements and fasting blood sampling. The blood sample was analyzed for insulin, glucose, glycated hemoglobin, leptin, adiponectin, insulin-like growth factor I, and high-sensitivity C-reactive protein. Multiple linear regression modeling, adjusted for sex, smoking, and parental overweight, was used to estimate the effect of fish oil relative to that of olive oil on BMI (in kg/m(2)), waist circumference, and biochemical measures. RESULTS: A total of 243 of the offspring were followed up. We found no difference between the fish-oil and olive oil groups in BMI (0.13; -0.92, 1.17) or waist circumference (0.7 cm; -2.1, 3.4 cm). Overall, results of the biochemical analyses supported the finding of no difference between the groups. CONCLUSION: We detected no effect of fish-oil supplementation during pregnancy on offspring adiposity in adolescence. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/21775563/Intake_of_fish_oil_during_pregnancy_and_adiposity_in_19_y_old_offspring:_follow_up_on_a_randomized_controlled_trial_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.111.014969 DB - PRIME DP - Unbound Medicine ER -