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Dietary fiber intake and risk of breast cancer: a meta-analysis of prospective cohort studies.
Am J Clin Nutr 2011; 94(3):900-5AJ

Abstract

BACKGROUND

Observational and preclinical studies suggest that dietary fiber intake may reduce the risk of breast cancer, but the results are inconclusive.

OBJECTIVE

We aimed to examine the association between dietary fiber intake and risk of breast cancer by conducting a meta-analysis of prospective cohort studies.

DESIGN

Relevant studies were identified by a PubMed database search through January 2011. Reference lists from retrieved articles were also reviewed. We included prospective cohort studies that reported RRs with 95% CIs for the association between dietary fiber intake and breast cancer risk. Both fixed- and random-effects models were used to calculate the summary risk estimates.

RESULTS

We identified 10 prospective cohort studies of dietary fiber intake and risk of breast cancer involving 16,848 cases and 712,195 participants. The combined RR of breast cancer for the highest compared with the lowest dietary fiber intake was 0.89 (95% CI: 0.83, 0.96), and little evidence of heterogeneity was observed. The association between dietary fiber intake and risk of breast cancer did not significantly differ by geographic region, length of follow-up, or menopausal status of the participants. Omission of any single study had little effect on the combined risk estimate. Dose-response analysis showed that every 10-g/d increment in dietary fiber intake was associated with a significant 7% reduction in breast cancer risk. Little evidence of publication bias was found.

CONCLUSION

This meta-analysis provides evidence of a significant inverse dose-response association between dietary fiber intake and breast cancer risk.

Authors+Show Affiliations

Department of Nutrition and Food Hygiene, School of Radiation Medicine and Public Health, Soochow University, Suzhou, China. dongjy@mail3.sysu.edu.cnNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

21775566

Citation

Dong, Jia-Yi, et al. "Dietary Fiber Intake and Risk of Breast Cancer: a Meta-analysis of Prospective Cohort Studies." The American Journal of Clinical Nutrition, vol. 94, no. 3, 2011, pp. 900-5.
Dong JY, He K, Wang P, et al. Dietary fiber intake and risk of breast cancer: a meta-analysis of prospective cohort studies. Am J Clin Nutr. 2011;94(3):900-5.
Dong, J. Y., He, K., Wang, P., & Qin, L. Q. (2011). Dietary fiber intake and risk of breast cancer: a meta-analysis of prospective cohort studies. The American Journal of Clinical Nutrition, 94(3), pp. 900-5. doi:10.3945/ajcn.111.015578.
Dong JY, et al. Dietary Fiber Intake and Risk of Breast Cancer: a Meta-analysis of Prospective Cohort Studies. Am J Clin Nutr. 2011;94(3):900-5. PubMed PMID: 21775566.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fiber intake and risk of breast cancer: a meta-analysis of prospective cohort studies. AU - Dong,Jia-Yi, AU - He,Ka, AU - Wang,Peiyu, AU - Qin,Li-Qiang, Y1 - 2011/07/20/ PY - 2011/7/22/entrez PY - 2011/7/22/pubmed PY - 2011/11/1/medline SP - 900 EP - 5 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 94 IS - 3 N2 - BACKGROUND: Observational and preclinical studies suggest that dietary fiber intake may reduce the risk of breast cancer, but the results are inconclusive. OBJECTIVE: We aimed to examine the association between dietary fiber intake and risk of breast cancer by conducting a meta-analysis of prospective cohort studies. DESIGN: Relevant studies were identified by a PubMed database search through January 2011. Reference lists from retrieved articles were also reviewed. We included prospective cohort studies that reported RRs with 95% CIs for the association between dietary fiber intake and breast cancer risk. Both fixed- and random-effects models were used to calculate the summary risk estimates. RESULTS: We identified 10 prospective cohort studies of dietary fiber intake and risk of breast cancer involving 16,848 cases and 712,195 participants. The combined RR of breast cancer for the highest compared with the lowest dietary fiber intake was 0.89 (95% CI: 0.83, 0.96), and little evidence of heterogeneity was observed. The association between dietary fiber intake and risk of breast cancer did not significantly differ by geographic region, length of follow-up, or menopausal status of the participants. Omission of any single study had little effect on the combined risk estimate. Dose-response analysis showed that every 10-g/d increment in dietary fiber intake was associated with a significant 7% reduction in breast cancer risk. Little evidence of publication bias was found. CONCLUSION: This meta-analysis provides evidence of a significant inverse dose-response association between dietary fiber intake and breast cancer risk. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/21775566/Dietary_fiber_intake_and_risk_of_breast_cancer:_a_meta_analysis_of_prospective_cohort_studies_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.111.015578 DB - PRIME DP - Unbound Medicine ER -