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Gestational diabetes mellitus causes changes in the concentrations of adipocyte fatty acid-binding protein and other adipocytokines in cord blood.
Diabetes Care 2011; 34(9):2061-6DC

Abstract

OBJECTIVE

To determine the concentrations of adipocyte fatty acid-binding protein (AFABP) and other adipocytokines in maternal and cord serum of pregnant women with gestational diabetes mellitus (GDM) and of control subjects and to relate them to indexes of insulin sensitivity.

RESEARCH DESIGN AND METHODS

In 86 control and 98 GDM pregnant women, venous blood was collected before vaginal delivery and arterial blood from cord immediately after delivery. Serum insulin and adipocytokines were measured by enzyme-linked immunosorbent assay (ELISA).

RESULTS

GDM women had higher prepregnancy BMI, and data were adjusted for it. Maternal serum insulin, insulin-to-glucose ratio, homeostasis model assessment (HOMA), AFABP, and retinol-binding protein 4 (RBP4) were higher and adiponectin was lower in GDM than in control subjects, whereas serum glucose, insulin, insulin-to-glucose ratio, HOMA, nonesterified fatty acids, and RBP4 were higher and glycerol, AFABP, and adiponectin were lower in cord blood serum of GDM than of control subjects. AFABP and adiponectin in cord serum of control subjects were higher than in maternal serum; in GDM women no difference was found for AFABP in cord versus maternal serum, although adiponectin remained higher in cord. Values of leptin in both groups were lower in cord than in maternal serum, and those of RBP4 were lower in only GDM women.

CONCLUSIONS

It is suggested that fetal tissues are the main source of cord arterial serum AFABP, and in GDM fetuses AFABP values correlate with adiposity markers. A downregulation of adiponectin and upregulation of RBP4 in GDM mothers and their fetuses may be related to their insulin-resistant condition, whereas changes in AFABP do not seem to be related.

Authors+Show Affiliations

University CEU San Pablo, Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21775757

Citation

Ortega-Senovilla, Henar, et al. "Gestational Diabetes Mellitus Causes Changes in the Concentrations of Adipocyte Fatty Acid-binding Protein and Other Adipocytokines in Cord Blood." Diabetes Care, vol. 34, no. 9, 2011, pp. 2061-6.
Ortega-Senovilla H, Schaefer-Graf U, Meitzner K, et al. Gestational diabetes mellitus causes changes in the concentrations of adipocyte fatty acid-binding protein and other adipocytokines in cord blood. Diabetes Care. 2011;34(9):2061-6.
Ortega-Senovilla, H., Schaefer-Graf, U., Meitzner, K., Abou-Dakn, M., Graf, K., Kintscher, U., & Herrera, E. (2011). Gestational diabetes mellitus causes changes in the concentrations of adipocyte fatty acid-binding protein and other adipocytokines in cord blood. Diabetes Care, 34(9), pp. 2061-6. doi:10.2337/dc11-0715.
Ortega-Senovilla H, et al. Gestational Diabetes Mellitus Causes Changes in the Concentrations of Adipocyte Fatty Acid-binding Protein and Other Adipocytokines in Cord Blood. Diabetes Care. 2011;34(9):2061-6. PubMed PMID: 21775757.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gestational diabetes mellitus causes changes in the concentrations of adipocyte fatty acid-binding protein and other adipocytokines in cord blood. AU - Ortega-Senovilla,Henar, AU - Schaefer-Graf,Ute, AU - Meitzner,Katrin, AU - Abou-Dakn,Michael, AU - Graf,Kristof, AU - Kintscher,Ulrich, AU - Herrera,Emilio, Y1 - 2011/07/20/ PY - 2011/7/22/entrez PY - 2011/7/22/pubmed PY - 2012/5/12/medline SP - 2061 EP - 6 JF - Diabetes care JO - Diabetes Care VL - 34 IS - 9 N2 - OBJECTIVE: To determine the concentrations of adipocyte fatty acid-binding protein (AFABP) and other adipocytokines in maternal and cord serum of pregnant women with gestational diabetes mellitus (GDM) and of control subjects and to relate them to indexes of insulin sensitivity. RESEARCH DESIGN AND METHODS: In 86 control and 98 GDM pregnant women, venous blood was collected before vaginal delivery and arterial blood from cord immediately after delivery. Serum insulin and adipocytokines were measured by enzyme-linked immunosorbent assay (ELISA). RESULTS: GDM women had higher prepregnancy BMI, and data were adjusted for it. Maternal serum insulin, insulin-to-glucose ratio, homeostasis model assessment (HOMA), AFABP, and retinol-binding protein 4 (RBP4) were higher and adiponectin was lower in GDM than in control subjects, whereas serum glucose, insulin, insulin-to-glucose ratio, HOMA, nonesterified fatty acids, and RBP4 were higher and glycerol, AFABP, and adiponectin were lower in cord blood serum of GDM than of control subjects. AFABP and adiponectin in cord serum of control subjects were higher than in maternal serum; in GDM women no difference was found for AFABP in cord versus maternal serum, although adiponectin remained higher in cord. Values of leptin in both groups were lower in cord than in maternal serum, and those of RBP4 were lower in only GDM women. CONCLUSIONS: It is suggested that fetal tissues are the main source of cord arterial serum AFABP, and in GDM fetuses AFABP values correlate with adiposity markers. A downregulation of adiponectin and upregulation of RBP4 in GDM mothers and their fetuses may be related to their insulin-resistant condition, whereas changes in AFABP do not seem to be related. SN - 1935-5548 UR - https://www.unboundmedicine.com/medline/citation/21775757/Gestational_diabetes_mellitus_causes_changes_in_the_concentrations_of_adipocyte_fatty_acid_binding_protein_and_other_adipocytokines_in_cord_blood_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&pmid=21775757 DB - PRIME DP - Unbound Medicine ER -