Tags

Type your tag names separated by a space and hit enter

Clinical significance of portal-superior mesenteric vein resection in pancreatoduodenectomy for pancreatic head cancer.
Pancreas. 2012 Jan; 41(1):102-6.P

Abstract

OBJECTIVES

The purpose of this study was to determine the significance of portal vein-superior mesenteric vein (PV-SMV) invasion on survival in patients who underwent margin-negative pancreatoduodenectomy (PD) with PV-SMV resection for pancreatic adenocarcinoma.

METHODS

We retrospectively reviewed the records of 60 patients who underwent margin-negative PD with or without PV-SMV resection for pancreatic adenocarcinoma between August 2001 and December 2007. The depth of vessel invasion was investigated and was categorized into 3 groups: tunica adventitia, media, and intima. Clinicopathologic factors and survival were analyzed.

RESULTS

Portal vein-superior mesenteric vein resection was performed on 19 patients, but only 15 patients (78.9%) had histologically true invasion and showed poorer survival (median survival, 14 vs 9 months; P < 0.05). Univariate analysis revealed that poorly differentiated tumor, lymphatic invasion, endovascular invasion, PV-SMV invasion, and invasion into the intima of PV-SMV were statistically significant. Poorly differentiated tumor and invasion into the intima of PV-SMV were significant in multivariate analysis.

CONCLUSIONS

Aggressive surgical resection should be attempted in cases with suspected PV-SMV invasion because 21.1% of patients had no true invasion and showed better survival than those with true invasion. However, invasion into the tunica intima may be a poor prognostic factor for survival even after margin-negative PD for pancreatic adenocarcinoma.

Authors+Show Affiliations

Center for Liver Cancer, National Cancer Center, Gyeonggi-do, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21775914

Citation

Han, Sung-Sik, et al. "Clinical Significance of Portal-superior Mesenteric Vein Resection in Pancreatoduodenectomy for Pancreatic Head Cancer." Pancreas, vol. 41, no. 1, 2012, pp. 102-6.
Han SS, Park SJ, Kim SH, et al. Clinical significance of portal-superior mesenteric vein resection in pancreatoduodenectomy for pancreatic head cancer. Pancreas. 2012;41(1):102-6.
Han, S. S., Park, S. J., Kim, S. H., Cho, S. Y., Kim, Y. K., Kim, T. H., Lee, S. A., Woo, S. M., Lee, W. J., & Hong, E. K. (2012). Clinical significance of portal-superior mesenteric vein resection in pancreatoduodenectomy for pancreatic head cancer. Pancreas, 41(1), 102-6. https://doi.org/10.1097/MPA.0b013e318221c595
Han SS, et al. Clinical Significance of Portal-superior Mesenteric Vein Resection in Pancreatoduodenectomy for Pancreatic Head Cancer. Pancreas. 2012;41(1):102-6. PubMed PMID: 21775914.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical significance of portal-superior mesenteric vein resection in pancreatoduodenectomy for pancreatic head cancer. AU - Han,Sung-Sik, AU - Park,Sang-Jae, AU - Kim,Seong Hoon, AU - Cho,Seong Yeon, AU - Kim,Young-Kyu, AU - Kim,Tae Hyun, AU - Lee,Soon-ae, AU - Woo,Sang Myung, AU - Lee,Woo Jin, AU - Hong,Eun Kyung, PY - 2011/7/22/entrez PY - 2011/7/22/pubmed PY - 2012/5/23/medline SP - 102 EP - 6 JF - Pancreas JO - Pancreas VL - 41 IS - 1 N2 - OBJECTIVES: The purpose of this study was to determine the significance of portal vein-superior mesenteric vein (PV-SMV) invasion on survival in patients who underwent margin-negative pancreatoduodenectomy (PD) with PV-SMV resection for pancreatic adenocarcinoma. METHODS: We retrospectively reviewed the records of 60 patients who underwent margin-negative PD with or without PV-SMV resection for pancreatic adenocarcinoma between August 2001 and December 2007. The depth of vessel invasion was investigated and was categorized into 3 groups: tunica adventitia, media, and intima. Clinicopathologic factors and survival were analyzed. RESULTS: Portal vein-superior mesenteric vein resection was performed on 19 patients, but only 15 patients (78.9%) had histologically true invasion and showed poorer survival (median survival, 14 vs 9 months; P < 0.05). Univariate analysis revealed that poorly differentiated tumor, lymphatic invasion, endovascular invasion, PV-SMV invasion, and invasion into the intima of PV-SMV were statistically significant. Poorly differentiated tumor and invasion into the intima of PV-SMV were significant in multivariate analysis. CONCLUSIONS: Aggressive surgical resection should be attempted in cases with suspected PV-SMV invasion because 21.1% of patients had no true invasion and showed better survival than those with true invasion. However, invasion into the tunica intima may be a poor prognostic factor for survival even after margin-negative PD for pancreatic adenocarcinoma. SN - 1536-4828 UR - https://www.unboundmedicine.com/medline/citation/21775914/Clinical_significance_of_portal_superior_mesenteric_vein_resection_in_pancreatoduodenectomy_for_pancreatic_head_cancer_ L2 - http://dx.doi.org/10.1097/MPA.0b013e318221c595 DB - PRIME DP - Unbound Medicine ER -