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Combining nutrition, food science and engineering in developing solutions to Inflammatory bowel diseases--omega-3 polyunsaturated fatty acids as an example.

Abstract

The Inflammatory bowel diseases, Crohn's disease and ulcerative colitis, are debilitating conditions, characterised by lifelong sensitivity to certain foods, and often a need for surgery and life-long medication. The anti-inflammatory effects of long chain omega-3 polyunsaturated acids justify their inclusion in enteral nutrition formulas that have been associated with disease remission. However, there have been variable data in clinical trials to test supplementary omega-3 polyunsaturated fatty acids in inducing or maintaining remission in these diseases. Although variability in trial design has been suggested as a major factor, we suggest that variability in processing and presentation of the products may be equally or more important. The nature of the source, and rapidity of getting the fish or other food source to processing or to market, will affect the percentage of the various fatty acids, possible presence of heavy metal contaminants and oxidation status of the various fatty acids. For dietary supplements or fortified foods, whether the product is encapsulated or not, whether storage is under nitrogen or not, and length of time between harvest, processing and marketing will again profoundly affect the properties of the final product. Clinical trials to test efficacy of these products in IBD to date have utilised the relevant skills of pharmacology and gastroenterology. We suggest that knowledge from food science, nutrition and engineering will be essential to establish the true role of this important group of compounds in these diseases.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Discipline of Nutrition, FM&HS, The University of Auckland, Auckland, New Zealand.

    ,

    Source

    Food & function 1:1 2010 Oct pg 60-72

    MeSH

    Biological Availability
    Clinical Trials as Topic
    Colitis, Ulcerative
    Crohn Disease
    Diet
    Dietary Supplements
    Drug Stability
    Fatty Acids, Omega-3
    Fatty Acids, Omega-6
    Food Technology
    Food, Fortified
    Humans
    Inflammatory Bowel Diseases
    Nutritional Physiological Phenomena
    Treatment Outcome

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    21776456

    Citation

    Ferguson, Lynnette R., et al. "Combining Nutrition, Food Science and Engineering in Developing Solutions to Inflammatory Bowel Diseases--omega-3 Polyunsaturated Fatty Acids as an Example." Food & Function, vol. 1, no. 1, 2010, pp. 60-72.
    Ferguson LR, Smith BG, James BJ. Combining nutrition, food science and engineering in developing solutions to Inflammatory bowel diseases--omega-3 polyunsaturated fatty acids as an example. Food Funct. 2010;1(1):60-72.
    Ferguson, L. R., Smith, B. G., & James, B. J. (2010). Combining nutrition, food science and engineering in developing solutions to Inflammatory bowel diseases--omega-3 polyunsaturated fatty acids as an example. Food & Function, 1(1), pp. 60-72. doi:10.1039/c0fo00057d.
    Ferguson LR, Smith BG, James BJ. Combining Nutrition, Food Science and Engineering in Developing Solutions to Inflammatory Bowel Diseases--omega-3 Polyunsaturated Fatty Acids as an Example. Food Funct. 2010;1(1):60-72. PubMed PMID: 21776456.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Combining nutrition, food science and engineering in developing solutions to Inflammatory bowel diseases--omega-3 polyunsaturated fatty acids as an example. AU - Ferguson,Lynnette R, AU - Smith,Bronwen G, AU - James,Bryony J, Y1 - 2010/09/22/ PY - 2011/7/22/entrez PY - 2010/1/10/pubmed PY - 2012/1/18/medline SP - 60 EP - 72 JF - Food & function JO - Food Funct VL - 1 IS - 1 N2 - The Inflammatory bowel diseases, Crohn's disease and ulcerative colitis, are debilitating conditions, characterised by lifelong sensitivity to certain foods, and often a need for surgery and life-long medication. The anti-inflammatory effects of long chain omega-3 polyunsaturated acids justify their inclusion in enteral nutrition formulas that have been associated with disease remission. However, there have been variable data in clinical trials to test supplementary omega-3 polyunsaturated fatty acids in inducing or maintaining remission in these diseases. Although variability in trial design has been suggested as a major factor, we suggest that variability in processing and presentation of the products may be equally or more important. The nature of the source, and rapidity of getting the fish or other food source to processing or to market, will affect the percentage of the various fatty acids, possible presence of heavy metal contaminants and oxidation status of the various fatty acids. For dietary supplements or fortified foods, whether the product is encapsulated or not, whether storage is under nitrogen or not, and length of time between harvest, processing and marketing will again profoundly affect the properties of the final product. Clinical trials to test efficacy of these products in IBD to date have utilised the relevant skills of pharmacology and gastroenterology. We suggest that knowledge from food science, nutrition and engineering will be essential to establish the true role of this important group of compounds in these diseases. SN - 2042-650X UR - https://www.unboundmedicine.com/medline/citation/21776456/Combining_nutrition_food_science_and_engineering_in_developing_solutions_to_Inflammatory_bowel_diseases__omega_3_polyunsaturated_fatty_acids_as_an_example_ L2 - https://doi.org/10.1039/c0fo00057d DB - PRIME DP - Unbound Medicine ER -