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Four-year weight losses in the Look AHEAD study: factors associated with long-term success.
Obesity (Silver Spring). 2011 Oct; 19(10):1987-98.O

Abstract

This report provides a further analysis of the year 4 weight losses in the Look AHEAD (Action for Health in Diabetes) study and identifies factors associated with long-term success. A total of 5,145 overweight/obese men and women with type 2 diabetes were randomly assigned to an intensive lifestyle intervention (ILI) or a usual care group, referred to as Diabetes Support and Education (DSE). ILI participants were provided approximately weekly group or individual treatment in year 1; continued but less frequent contact was provided in years 2-4. DSE participants received three group educational sessions in all years. As reported previously, at year 4, ILI participants lost an average of 4.7% of initial weight, compared with 1.1% for DSE (P < 0.0001). More ILI than DSE participants lost ≥ 5% (46% vs. 25%, P < 0.0001) and ≥ 10% (23% vs. 10%, P < 0.0001) of initial weight. Within the ILI, achievement of both the 5% and 10% categorical weight losses at year 4 was strongly related to meeting these goals at year 1. A total of 887 participants in ILI lost ≥ 10% at year 1, of whom 374 (42.2%) achieved this loss at year 4. Participants who maintained the loss, compared with those who did not, attended more treatment sessions and reported more favorable physical activity and food intake at year 4. These results provide critical evidence that a comprehensive lifestyle intervention can induce clinically significant weight loss (i.e., ≥ 5%) in overweight/obese participants with type 2 diabetes and maintain this loss in more than 45% of patients at 4 years.

Authors+Show Affiliations

Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. Wadden@mail.med.upenn.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

21779086

Citation

Wadden, Thomas A., et al. "Four-year Weight Losses in the Look AHEAD Study: Factors Associated With Long-term Success." Obesity (Silver Spring, Md.), vol. 19, no. 10, 2011, pp. 1987-98.
Wadden TA, Neiberg RH, Wing RR, et al. Four-year weight losses in the Look AHEAD study: factors associated with long-term success. Obesity (Silver Spring). 2011;19(10):1987-98.
Wadden, T. A., Neiberg, R. H., Wing, R. R., Clark, J. M., Delahanty, L. M., Hill, J. O., Krakoff, J., Otto, A., Ryan, D. H., & Vitolins, M. Z. (2011). Four-year weight losses in the Look AHEAD study: factors associated with long-term success. Obesity (Silver Spring, Md.), 19(10), 1987-98. https://doi.org/10.1038/oby.2011.230
Wadden TA, et al. Four-year Weight Losses in the Look AHEAD Study: Factors Associated With Long-term Success. Obesity (Silver Spring). 2011;19(10):1987-98. PubMed PMID: 21779086.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Four-year weight losses in the Look AHEAD study: factors associated with long-term success. AU - Wadden,Thomas A, AU - Neiberg,Rebecca H, AU - Wing,Rena R, AU - Clark,Jeanne M, AU - Delahanty,Linda M, AU - Hill,James O, AU - Krakoff,Jonathan, AU - Otto,Amy, AU - Ryan,Donna H, AU - Vitolins,Mara Z, AU - ,, Y1 - 2011/07/21/ PY - 2011/7/23/entrez PY - 2011/7/23/pubmed PY - 2012/3/28/medline SP - 1987 EP - 98 JF - Obesity (Silver Spring, Md.) JO - Obesity (Silver Spring) VL - 19 IS - 10 N2 - This report provides a further analysis of the year 4 weight losses in the Look AHEAD (Action for Health in Diabetes) study and identifies factors associated with long-term success. A total of 5,145 overweight/obese men and women with type 2 diabetes were randomly assigned to an intensive lifestyle intervention (ILI) or a usual care group, referred to as Diabetes Support and Education (DSE). ILI participants were provided approximately weekly group or individual treatment in year 1; continued but less frequent contact was provided in years 2-4. DSE participants received three group educational sessions in all years. As reported previously, at year 4, ILI participants lost an average of 4.7% of initial weight, compared with 1.1% for DSE (P < 0.0001). More ILI than DSE participants lost ≥ 5% (46% vs. 25%, P < 0.0001) and ≥ 10% (23% vs. 10%, P < 0.0001) of initial weight. Within the ILI, achievement of both the 5% and 10% categorical weight losses at year 4 was strongly related to meeting these goals at year 1. A total of 887 participants in ILI lost ≥ 10% at year 1, of whom 374 (42.2%) achieved this loss at year 4. Participants who maintained the loss, compared with those who did not, attended more treatment sessions and reported more favorable physical activity and food intake at year 4. These results provide critical evidence that a comprehensive lifestyle intervention can induce clinically significant weight loss (i.e., ≥ 5%) in overweight/obese participants with type 2 diabetes and maintain this loss in more than 45% of patients at 4 years. SN - 1930-739X UR - https://www.unboundmedicine.com/medline/citation/21779086/Four_year_weight_losses_in_the_Look_AHEAD_study:_factors_associated_with_long_term_success_ L2 - https://doi.org/10.1038/oby.2011.230 DB - PRIME DP - Unbound Medicine ER -