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The role of IL-15 deficiency in the pathogenesis of virus-induced asthma exacerbations.
PLoS Pathog 2011; 7(7):e1002114PP

Abstract

Rhinovirus infections are the major cause of asthma exacerbations. We hypothesised that IL-15, a cytokine implicated in innate and acquired antiviral immunity, may be deficient in asthma and important in the pathogenesis of asthma exacerbations. We investigated regulation of IL-15 induction by rhinovirus in human macrophages in vitro, IL-15 levels in bronchoalveolar lavage (BAL) fluid and IL-15 induction by rhinovirus in BAL macrophages from asthmatic and control subjects, and related these to outcomes of infection in vivo. Rhinovirus induced IL-15 in macrophages was replication-, NF-κB- and α/β interferon-dependent. BAL macrophage IL-15 induction by rhinovirus was impaired in asthmatics and inversely related to lower respiratory symptom severity during experimental rhinovirus infection. IL-15 levels in BAL fluid were also decreased in asthmatics and inversely related with airway hyperresponsiveness and with virus load during in vivo rhinovirus infection. Deficient IL-15 production in asthma may be important in the pathogenesis of asthma exacerbations.

Authors+Show Affiliations

Department of Respiratory Medicine, National Heart and Lung Institute, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, Centre for Respiratory Infection, Imperial College London, London, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21779162

Citation

Laza-Stanca, Vasile, et al. "The Role of IL-15 Deficiency in the Pathogenesis of Virus-induced Asthma Exacerbations." PLoS Pathogens, vol. 7, no. 7, 2011, pp. e1002114.
Laza-Stanca V, Message SD, Edwards MR, et al. The role of IL-15 deficiency in the pathogenesis of virus-induced asthma exacerbations. PLoS Pathog. 2011;7(7):e1002114.
Laza-Stanca, V., Message, S. D., Edwards, M. R., Parker, H. L., Zdrenghea, M. T., Kebadze, T., ... Johnston, S. L. (2011). The role of IL-15 deficiency in the pathogenesis of virus-induced asthma exacerbations. PLoS Pathogens, 7(7), pp. e1002114. doi:10.1371/journal.ppat.1002114.
Laza-Stanca V, et al. The Role of IL-15 Deficiency in the Pathogenesis of Virus-induced Asthma Exacerbations. PLoS Pathog. 2011;7(7):e1002114. PubMed PMID: 21779162.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of IL-15 deficiency in the pathogenesis of virus-induced asthma exacerbations. AU - Laza-Stanca,Vasile, AU - Message,Simon D, AU - Edwards,Michael R, AU - Parker,Hayley L, AU - Zdrenghea,Mihnea T, AU - Kebadze,Tatiana, AU - Kon,Onn M, AU - Mallia,Patrick, AU - Stanciu,Luminita A, AU - Johnston,Sebastian L, Y1 - 2011/07/14/ PY - 2010/09/13/received PY - 2011/04/26/accepted PY - 2011/7/23/entrez PY - 2011/7/23/pubmed PY - 2011/11/15/medline SP - e1002114 EP - e1002114 JF - PLoS pathogens JO - PLoS Pathog. VL - 7 IS - 7 N2 - Rhinovirus infections are the major cause of asthma exacerbations. We hypothesised that IL-15, a cytokine implicated in innate and acquired antiviral immunity, may be deficient in asthma and important in the pathogenesis of asthma exacerbations. We investigated regulation of IL-15 induction by rhinovirus in human macrophages in vitro, IL-15 levels in bronchoalveolar lavage (BAL) fluid and IL-15 induction by rhinovirus in BAL macrophages from asthmatic and control subjects, and related these to outcomes of infection in vivo. Rhinovirus induced IL-15 in macrophages was replication-, NF-κB- and α/β interferon-dependent. BAL macrophage IL-15 induction by rhinovirus was impaired in asthmatics and inversely related to lower respiratory symptom severity during experimental rhinovirus infection. IL-15 levels in BAL fluid were also decreased in asthmatics and inversely related with airway hyperresponsiveness and with virus load during in vivo rhinovirus infection. Deficient IL-15 production in asthma may be important in the pathogenesis of asthma exacerbations. SN - 1553-7374 UR - https://www.unboundmedicine.com/medline/citation/21779162/The_role_of_IL_15_deficiency_in_the_pathogenesis_of_virus_induced_asthma_exacerbations_ L2 - http://dx.plos.org/10.1371/journal.ppat.1002114 DB - PRIME DP - Unbound Medicine ER -