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Diagnosis of colorectal hepatic metastases: comparison of contrast-enhanced CT, contrast-enhanced US, superparamagnetic iron oxide-enhanced MRI, and gadoxetic acid-enhanced MRI.
J Magn Reson Imaging. 2011 Aug; 34(2):326-35.JM

Abstract

PURPOSE

To compare the diagnostic accuracy of contrast-enhanced computed tomography (CE-CT), contrast-enhanced ultrasonography (CE-US), superparamagnetic iron oxide-enhanced magnetic resonance imaging (SPIO-MRI), and gadoxetic acid-enhanced MRI (Gd-EOB-MRI) in the evaluation of colorectal hepatic metastases.

MATERIALS AND METHODS

In all, 111 patients with colorectal cancers were enrolled in this study. Of the 112 metastases identified in 46 patients, 31 in 18 patients were confirmed histologically and the remaining 81 in 28 patients were confirmed by follow-up imaging. CE-CT, CE-US, SPIO-MRI, and Gd-EOB-MRI were evaluated. Mean (of three readers, except for CE-US) area under the receiver operating characteristic curve (A(z)), sensitivities, and positive predictive values (PPV) were calculated. Each value was compared to the others by variance z-test or chi-square test with Bonferroni correction.

RESULTS

For all lesions, mean A(z) and sensitivity of Gd-EOB-MRI (0.992, 95% [56/59]) were significantly greater than those of CE-CT (0.847, 63% [71/112]) and CE-US (0.844, 73% [77/106]). For lesions ≤1 cm, mean A(z) and sensitivity of Gd-EOB-MRI (0.999, 92% [22/24]) were significantly greater than those of CE-CT (0.685, 26% [13/50]) and CE-US (0.7, 41% [18/44]). Mean A(z) (95% CI) of SPIO-MRI for all lesions (0.966 [0.929-0.987]) and lesions ≤ 1 cm (0.961 [0.911-0.988]) were significantly greater than those of CE-CT and CE-US. Mean sensitivity of SPIO-MRI for lesions ≤1 cm (63%, 26/41) was significantly greater than that of CE-CT.

CONCLUSION

Gd-EOB-MRI and SPIO-MRI were more accurate than CE-CT and CE-US for evaluation of liver metastasis in patients with colorectal carcinoma.

Authors+Show Affiliations

Department of Radiology, University of Yamanashi, Yamanshi, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21780227

Citation

Muhi, Ali, et al. "Diagnosis of Colorectal Hepatic Metastases: Comparison of Contrast-enhanced CT, Contrast-enhanced US, Superparamagnetic Iron Oxide-enhanced MRI, and Gadoxetic Acid-enhanced MRI." Journal of Magnetic Resonance Imaging : JMRI, vol. 34, no. 2, 2011, pp. 326-35.
Muhi A, Ichikawa T, Motosugi U, et al. Diagnosis of colorectal hepatic metastases: comparison of contrast-enhanced CT, contrast-enhanced US, superparamagnetic iron oxide-enhanced MRI, and gadoxetic acid-enhanced MRI. J Magn Reson Imaging. 2011;34(2):326-35.
Muhi, A., Ichikawa, T., Motosugi, U., Sou, H., Nakajima, H., Sano, K., Sano, M., Kato, S., Kitamura, T., Fatima, Z., Fukushima, K., Iino, H., Mori, Y., Fujii, H., & Araki, T. (2011). Diagnosis of colorectal hepatic metastases: comparison of contrast-enhanced CT, contrast-enhanced US, superparamagnetic iron oxide-enhanced MRI, and gadoxetic acid-enhanced MRI. Journal of Magnetic Resonance Imaging : JMRI, 34(2), 326-35. https://doi.org/10.1002/jmri.22613
Muhi A, et al. Diagnosis of Colorectal Hepatic Metastases: Comparison of Contrast-enhanced CT, Contrast-enhanced US, Superparamagnetic Iron Oxide-enhanced MRI, and Gadoxetic Acid-enhanced MRI. J Magn Reson Imaging. 2011;34(2):326-35. PubMed PMID: 21780227.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnosis of colorectal hepatic metastases: comparison of contrast-enhanced CT, contrast-enhanced US, superparamagnetic iron oxide-enhanced MRI, and gadoxetic acid-enhanced MRI. AU - Muhi,Ali, AU - Ichikawa,Tomoaki, AU - Motosugi,Utaroh, AU - Sou,Hironobu, AU - Nakajima,Hiroto, AU - Sano,Katsuhiro, AU - Sano,Mika, AU - Kato,Satoshi, AU - Kitamura,Takatoshi, AU - Fatima,Zareen, AU - Fukushima,Kimiyo, AU - Iino,Hiroshi, AU - Mori,Yoshiyuki, AU - Fujii,Hideki, AU - Araki,Tsutomu, PY - 2011/7/23/entrez PY - 2011/7/23/pubmed PY - 2012/1/24/medline SP - 326 EP - 35 JF - Journal of magnetic resonance imaging : JMRI JO - J Magn Reson Imaging VL - 34 IS - 2 N2 - PURPOSE: To compare the diagnostic accuracy of contrast-enhanced computed tomography (CE-CT), contrast-enhanced ultrasonography (CE-US), superparamagnetic iron oxide-enhanced magnetic resonance imaging (SPIO-MRI), and gadoxetic acid-enhanced MRI (Gd-EOB-MRI) in the evaluation of colorectal hepatic metastases. MATERIALS AND METHODS: In all, 111 patients with colorectal cancers were enrolled in this study. Of the 112 metastases identified in 46 patients, 31 in 18 patients were confirmed histologically and the remaining 81 in 28 patients were confirmed by follow-up imaging. CE-CT, CE-US, SPIO-MRI, and Gd-EOB-MRI were evaluated. Mean (of three readers, except for CE-US) area under the receiver operating characteristic curve (A(z)), sensitivities, and positive predictive values (PPV) were calculated. Each value was compared to the others by variance z-test or chi-square test with Bonferroni correction. RESULTS: For all lesions, mean A(z) and sensitivity of Gd-EOB-MRI (0.992, 95% [56/59]) were significantly greater than those of CE-CT (0.847, 63% [71/112]) and CE-US (0.844, 73% [77/106]). For lesions ≤1 cm, mean A(z) and sensitivity of Gd-EOB-MRI (0.999, 92% [22/24]) were significantly greater than those of CE-CT (0.685, 26% [13/50]) and CE-US (0.7, 41% [18/44]). Mean A(z) (95% CI) of SPIO-MRI for all lesions (0.966 [0.929-0.987]) and lesions ≤ 1 cm (0.961 [0.911-0.988]) were significantly greater than those of CE-CT and CE-US. Mean sensitivity of SPIO-MRI for lesions ≤1 cm (63%, 26/41) was significantly greater than that of CE-CT. CONCLUSION: Gd-EOB-MRI and SPIO-MRI were more accurate than CE-CT and CE-US for evaluation of liver metastasis in patients with colorectal carcinoma. SN - 1522-2586 UR - https://www.unboundmedicine.com/medline/citation/21780227/Diagnosis_of_colorectal_hepatic_metastases:_comparison_of_contrast_enhanced_CT_contrast_enhanced_US_superparamagnetic_iron_oxide_enhanced_MRI_and_gadoxetic_acid_enhanced_MRI_ L2 - https://doi.org/10.1002/jmri.22613 DB - PRIME DP - Unbound Medicine ER -