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Hepatitis B vaccination coverage among high-risk adults 18-49 years, U.S., 2009.
Vaccine. 2011 Sep 16; 29(40):7049-57.V

Abstract

BACKGROUND

Approximately 43,000 new hepatitis B virus (HBV) infections occurred in 2007. Although hepB vaccination has been recommended for adults at high-risk for incident HBV infection for many years, coverage remains low.

METHODS

We used the 2009 National Health Interview Survey to assess self-reported HepB vaccine uptake (≥ 1 dose), series completion (≥ 3 dose), and independent predictors of vaccination among high-risk adults aged 18-49 years. High-risk adults were defined as those reporting male sex with men; injection drug use; hemophilia with receipt of clotting factors; sexually transmitted disease in prior five years; sex for money or drugs; HIV positive; sex with persons having any above risk factors; or who "felt they were at high risk for HIV". Persons with none of the aforementioned risk factors were considered non-high risk. Bivariate analysis was conducted to assess vaccination coverage. Independent predictors of vaccine uptake and series completion were determined using a logistic regression.

RESULTS

Overall, 7.0% adults aged 18-49 years had high-risk behaviors. Unadjusted coverage with ≥ 1 dose was 50.5% among high-risk compared to 40.5% among non-high-risk adults (p-values <0.001) while series completion (≥ 3 doses) was 41.8% and 34.2%, respectively (p-values <0.001). On multivariable analysis, ≥ 1 dose coverage, but not series completion, was higher (Risk Ratio 1.1, 95% CI=1.0-1.2, p-value=0.021) among high-risk compared to non-high risk adults. Other characteristics independently associated with a higher likelihood of HepB vaccination among persons 18-49 years included younger age groups, females, higher education, ≥ 2 physician contacts in the past year, ever tested for HIV, health care personnel, received influenza vaccination in the previous year, and ever received hepatitis A vaccination. Vaccine uptake with ≥ 1 dose increased by 5.1% (p=0.047) among high-risk adults between 2004 and 2009.

CONCLUSIONS

A small increase in ≥ 1 dose HepB vaccination coverage among high-risk adults compared with non-high risk adults was documented for the first time in 2009. Higher coverage among persons 18-30 years may reflect aging of persons vaccinated when they were children and adolescents. To improve protection against hepatitis B among high-risk adults, healthcare providers should offer hepatitis B vaccination to persons at high risk and those who seek vaccination to protect themselves and facilitate timely completion of the three (3) dose HepB series.

Authors+Show Affiliations

Immunization Services Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, NE, Mail Stop E-62, Atlanta, GA 30333, USA. plu@cdc.govNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21782873

Citation

Lu, Peng-jun, et al. "Hepatitis B Vaccination Coverage Among High-risk Adults 18-49 Years, U.S., 2009." Vaccine, vol. 29, no. 40, 2011, pp. 7049-57.
Lu PJ, Byrd KK, Murphy TV, et al. Hepatitis B vaccination coverage among high-risk adults 18-49 years, U.S., 2009. Vaccine. 2011;29(40):7049-57.
Lu, P. J., Byrd, K. K., Murphy, T. V., & Weinbaum, C. (2011). Hepatitis B vaccination coverage among high-risk adults 18-49 years, U.S., 2009. Vaccine, 29(40), 7049-57. https://doi.org/10.1016/j.vaccine.2011.07.030
Lu PJ, et al. Hepatitis B Vaccination Coverage Among High-risk Adults 18-49 Years, U.S., 2009. Vaccine. 2011 Sep 16;29(40):7049-57. PubMed PMID: 21782873.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatitis B vaccination coverage among high-risk adults 18-49 years, U.S., 2009. AU - Lu,Peng-jun, AU - Byrd,Kathy K, AU - Murphy,Trudy V, AU - Weinbaum,Cindy, Y1 - 2011/07/22/ PY - 2011/03/10/received PY - 2011/07/06/revised PY - 2011/07/08/accepted PY - 2011/7/26/entrez PY - 2011/7/26/pubmed PY - 2012/3/8/medline SP - 7049 EP - 57 JF - Vaccine JO - Vaccine VL - 29 IS - 40 N2 - BACKGROUND: Approximately 43,000 new hepatitis B virus (HBV) infections occurred in 2007. Although hepB vaccination has been recommended for adults at high-risk for incident HBV infection for many years, coverage remains low. METHODS: We used the 2009 National Health Interview Survey to assess self-reported HepB vaccine uptake (≥ 1 dose), series completion (≥ 3 dose), and independent predictors of vaccination among high-risk adults aged 18-49 years. High-risk adults were defined as those reporting male sex with men; injection drug use; hemophilia with receipt of clotting factors; sexually transmitted disease in prior five years; sex for money or drugs; HIV positive; sex with persons having any above risk factors; or who "felt they were at high risk for HIV". Persons with none of the aforementioned risk factors were considered non-high risk. Bivariate analysis was conducted to assess vaccination coverage. Independent predictors of vaccine uptake and series completion were determined using a logistic regression. RESULTS: Overall, 7.0% adults aged 18-49 years had high-risk behaviors. Unadjusted coverage with ≥ 1 dose was 50.5% among high-risk compared to 40.5% among non-high-risk adults (p-values <0.001) while series completion (≥ 3 doses) was 41.8% and 34.2%, respectively (p-values <0.001). On multivariable analysis, ≥ 1 dose coverage, but not series completion, was higher (Risk Ratio 1.1, 95% CI=1.0-1.2, p-value=0.021) among high-risk compared to non-high risk adults. Other characteristics independently associated with a higher likelihood of HepB vaccination among persons 18-49 years included younger age groups, females, higher education, ≥ 2 physician contacts in the past year, ever tested for HIV, health care personnel, received influenza vaccination in the previous year, and ever received hepatitis A vaccination. Vaccine uptake with ≥ 1 dose increased by 5.1% (p=0.047) among high-risk adults between 2004 and 2009. CONCLUSIONS: A small increase in ≥ 1 dose HepB vaccination coverage among high-risk adults compared with non-high risk adults was documented for the first time in 2009. Higher coverage among persons 18-30 years may reflect aging of persons vaccinated when they were children and adolescents. To improve protection against hepatitis B among high-risk adults, healthcare providers should offer hepatitis B vaccination to persons at high risk and those who seek vaccination to protect themselves and facilitate timely completion of the three (3) dose HepB series. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/21782873/Hepatitis_B_vaccination_coverage_among_high_risk_adults_18_49_years_U_S__2009_ DB - PRIME DP - Unbound Medicine ER -