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Vitamin D deficiency diminishes the severity and delays onset of experimental autoimmune encephalomyelitis.
Arch Biochem Biophys 2011; 513(2):140-3AB

Abstract

Multiple sclerosis incidence is clearly inversely related to sun exposure. This observation led to the idea that vitamin D might be responsible for this relationship. Providing super-physiologic doses of the hormonal form of vitamin D, 1α,25-dihydroxyvitamin D₃, suppresses an animal model of multiple sclerosis, i.e. experimental autoimmune encephalomyelitis (EAE) but causes unwanted hypercalcemia. Further, dietary calcium is needed for this activity of 1α,25-dihydroxyvitamin D₃. B10PL mice were maintained on a vitamin D-deficient diet for two generations to produce frank vitamin D deficiency. These animals showed delayed onset and reduced severity of EAE compared to control animals on the same diet and given vitamin D₃ or provided a vitamin D-containing chow diet. Thus, vitamin D deficiency interferes with the development of this autoimmune disease rather than increasing susceptibility.

Authors+Show Affiliations

Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI 53706-1544, USA. deluca@biochem.wisc.edu

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21784056

Citation

DeLuca, Hector F., and Lori A. Plum. "Vitamin D Deficiency Diminishes the Severity and Delays Onset of Experimental Autoimmune Encephalomyelitis." Archives of Biochemistry and Biophysics, vol. 513, no. 2, 2011, pp. 140-3.
DeLuca HF, Plum LA. Vitamin D deficiency diminishes the severity and delays onset of experimental autoimmune encephalomyelitis. Arch Biochem Biophys. 2011;513(2):140-3.
DeLuca, H. F., & Plum, L. A. (2011). Vitamin D deficiency diminishes the severity and delays onset of experimental autoimmune encephalomyelitis. Archives of Biochemistry and Biophysics, 513(2), pp. 140-3. doi:10.1016/j.abb.2011.07.005.
DeLuca HF, Plum LA. Vitamin D Deficiency Diminishes the Severity and Delays Onset of Experimental Autoimmune Encephalomyelitis. Arch Biochem Biophys. 2011 Sep 15;513(2):140-3. PubMed PMID: 21784056.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D deficiency diminishes the severity and delays onset of experimental autoimmune encephalomyelitis. AU - DeLuca,Hector F, AU - Plum,Lori A, Y1 - 2011/07/19/ PY - 2011/05/26/received PY - 2011/06/30/revised PY - 2011/07/07/accepted PY - 2011/7/26/entrez PY - 2011/7/26/pubmed PY - 2011/10/15/medline SP - 140 EP - 3 JF - Archives of biochemistry and biophysics JO - Arch. Biochem. Biophys. VL - 513 IS - 2 N2 - Multiple sclerosis incidence is clearly inversely related to sun exposure. This observation led to the idea that vitamin D might be responsible for this relationship. Providing super-physiologic doses of the hormonal form of vitamin D, 1α,25-dihydroxyvitamin D₃, suppresses an animal model of multiple sclerosis, i.e. experimental autoimmune encephalomyelitis (EAE) but causes unwanted hypercalcemia. Further, dietary calcium is needed for this activity of 1α,25-dihydroxyvitamin D₃. B10PL mice were maintained on a vitamin D-deficient diet for two generations to produce frank vitamin D deficiency. These animals showed delayed onset and reduced severity of EAE compared to control animals on the same diet and given vitamin D₃ or provided a vitamin D-containing chow diet. Thus, vitamin D deficiency interferes with the development of this autoimmune disease rather than increasing susceptibility. SN - 1096-0384 UR - https://www.unboundmedicine.com/medline/citation/21784056/Vitamin_D_deficiency_diminishes_the_severity_and_delays_onset_of_experimental_autoimmune_encephalomyelitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-9861(11)00257-8 DB - PRIME DP - Unbound Medicine ER -