Citation
Hickey, Christina A., et al. "Early Volume Expansion During Diarrhea and Relative Nephroprotection During Subsequent Hemolytic Uremic Syndrome." Archives of Pediatrics & Adolescent Medicine, vol. 165, no. 10, 2011, pp. 884-9.
Hickey CA, Beattie TJ, Cowieson J, et al. Early volume expansion during diarrhea and relative nephroprotection during subsequent hemolytic uremic syndrome. Arch Pediatr Adolesc Med. 2011;165(10):884-9.
Hickey, C. A., Beattie, T. J., Cowieson, J., Miyashita, Y., Strife, C. F., Frem, J. C., Peterson, J. M., Butani, L., Jones, D. P., Havens, P. L., Patel, H. P., Wong, C. S., Andreoli, S. P., Rothbaum, R. J., Beck, A. M., & Tarr, P. I. (2011). Early volume expansion during diarrhea and relative nephroprotection during subsequent hemolytic uremic syndrome. Archives of Pediatrics & Adolescent Medicine, 165(10), 884-9. https://doi.org/10.1001/archpediatrics.2011.152
Hickey CA, et al. Early Volume Expansion During Diarrhea and Relative Nephroprotection During Subsequent Hemolytic Uremic Syndrome. Arch Pediatr Adolesc Med. 2011;165(10):884-9. PubMed PMID: 21784993.
TY - JOUR
T1 - Early volume expansion during diarrhea and relative nephroprotection during subsequent hemolytic uremic syndrome.
AU - Hickey,Christina A,
AU - Beattie,T James,
AU - Cowieson,Jennifer,
AU - Miyashita,Yosuke,
AU - Strife,C Frederic,
AU - Frem,Juliana C,
AU - Peterson,Johann M,
AU - Butani,Lavjay,
AU - Jones,Deborah P,
AU - Havens,Peter L,
AU - Patel,Hiren P,
AU - Wong,Craig S,
AU - Andreoli,Sharon P,
AU - Rothbaum,Robert J,
AU - Beck,Anne M,
AU - Tarr,Phillip I,
Y1 - 2011/07/22/
PY - 2011/7/26/entrez
PY - 2011/7/26/pubmed
PY - 2011/12/13/medline
SP - 884
EP - 9
JF - Archives of pediatrics & adolescent medicine
JO - Arch Pediatr Adolesc Med
VL - 165
IS - 10
N2 - OBJECTIVES: To determine if interventions during the pre-hemolytic uremic syndrome (HUS) diarrhea phase are associated with maintenance of urine output during HUS. DESIGN: Prospective observational cohort study. SETTINGS: Eleven pediatric hospitals in the United States and Scotland. PARTICIPANTS: Children younger than 18 years with diarrhea-associated HUS (hematocrit level <30% with smear evidence of intravascular erythrocyte destruction), thrombocytopenia (platelet count <150 × 10³/mm³), and impaired renal function (serum creatinine concentration > upper limit of reference range for age). INTERVENTIONS: Intravenous fluid was given within the first 4 days of the onset of diarrhea. OUTCOME MEASURE: Presence or absence of oligoanuria (urine output ≤ 0.5 mL/kg/h for >1 day). RESULTS: The overall oligoanuric rate of the 50 participants was 68%, but was 84% among those who received no intravenous fluids in the first 4 days of illness. The relative risk of oligoanuria when fluids were not given in this interval was 1.6 (95% confidence interval, 1.1-2.4; P = .02). Children with oligoanuric HUS were given less total intravenous fluid (r = -0.32; P = .02) and sodium (r = -0.27; P = .05) in the first 4 days of illness than those without oligoanuria. In multivariable analysis, the most significant covariate was volume infused, but volume and sodium strongly covaried. CONCLUSIONS: Intravenous volume expansion is an underused intervention that could decrease the frequency of oligoanuric renal failure in patients at risk of HUS.
SN - 1538-3628
UR - https://www.unboundmedicine.com/medline/citation/21784993/full_citation
L2 - https://jamanetwork.com/journals/jamapediatrics/fullarticle/10.1001/archpediatrics.2011.152
DB - PRIME
DP - Unbound Medicine
ER -