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Monocarboxylate transporter 4 (MCT4) and CD147 overexpression is associated with poor prognosis in prostate cancer.
BMC Cancer 2011; 11:312BC

Abstract

BACKGROUND

Monocarboxylate transporters (MCTs) are transmembrane proteins involved in the transport of monocarboxylates across the plasma membrane, which appear to play an important role in solid tumours, however the role of MCTs in prostate cancer is largely unknown. The aim of the present work was to evaluate the clinico-pathological value of monocarboxylate transporters (MCTs) expression, namely MCT1, MCT2 and MCT4, together with CD147 and gp70 as MCT1/4 and MCT2 chaperones, respectively, in prostate carcinoma.

METHODS

Prostate tissues were obtained from 171 patients, who performed radical prostatectomy and 14 patients who performed cystoprostatectomy. Samples and clinico-pathological data were retrieved and organized into tissue microarray (TMAs) blocks. Protein expression was evaluated by immunohistochemistry in neoplastic (n = 171), adjacent non-neoplastic tissues (n = 135), PIN lesions (n = 40) and normal prostatic tissue (n = 14). Protein expression was correlated with patients' clinicopathologic characteristics.

RESULTS

In the present study, a significant increase of MCT2 and MCT4 expression in the cytoplasm of tumour cells and a significant decrease in both MCT1 and CD147 expression in prostate tumour cells was observed when compared to normal tissue. All MCT isoforms and CD147 were expressed in PIN lesions. Importantly, for MCT2 and MCT4 the expression levels in PIN lesions were between normal and tumour tissue, which might indicate a role for these MCTs in the malignant transformation. Associations were found between MCT1, MCT4 and CD147 expressions and poor prognosis markers; importantly MCT4 and CD147 overexpression correlated with higher PSA levels, Gleason score and pT stage, as well as with perineural invasion and biochemical recurrence.

CONCLUSIONS

Our data provides novel evidence for the involvement of MCTs in prostate cancer. According to our results, we consider that MCT2 should be further explored as tumour marker and both MCT4 and CD147 as markers of poor prognosis in prostate cancer.

Authors+Show Affiliations

Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21787388

Citation

Pértega-Gomes, Nelma, et al. "Monocarboxylate Transporter 4 (MCT4) and CD147 Overexpression Is Associated With Poor Prognosis in Prostate Cancer." BMC Cancer, vol. 11, 2011, p. 312.
Pértega-Gomes N, Vizcaíno JR, Miranda-Gonçalves V, et al. Monocarboxylate transporter 4 (MCT4) and CD147 overexpression is associated with poor prognosis in prostate cancer. BMC Cancer. 2011;11:312.
Pértega-Gomes, N., Vizcaíno, J. R., Miranda-Gonçalves, V., Pinheiro, C., Silva, J., Pereira, H., ... Baltazar, F. (2011). Monocarboxylate transporter 4 (MCT4) and CD147 overexpression is associated with poor prognosis in prostate cancer. BMC Cancer, 11, p. 312. doi:10.1186/1471-2407-11-312.
Pértega-Gomes N, et al. Monocarboxylate Transporter 4 (MCT4) and CD147 Overexpression Is Associated With Poor Prognosis in Prostate Cancer. BMC Cancer. 2011 Jul 25;11:312. PubMed PMID: 21787388.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Monocarboxylate transporter 4 (MCT4) and CD147 overexpression is associated with poor prognosis in prostate cancer. AU - Pértega-Gomes,Nelma, AU - Vizcaíno,José R, AU - Miranda-Gonçalves,Vera, AU - Pinheiro,Céline, AU - Silva,Joana, AU - Pereira,Helena, AU - Monteiro,Pedro, AU - Henrique,Rui M, AU - Reis,Rui M, AU - Lopes,Carlos, AU - Baltazar,Fátima, Y1 - 2011/07/25/ PY - 2011/02/12/received PY - 2011/07/25/accepted PY - 2011/7/27/entrez PY - 2011/7/27/pubmed PY - 2012/2/7/medline SP - 312 EP - 312 JF - BMC cancer JO - BMC Cancer VL - 11 N2 - BACKGROUND: Monocarboxylate transporters (MCTs) are transmembrane proteins involved in the transport of monocarboxylates across the plasma membrane, which appear to play an important role in solid tumours, however the role of MCTs in prostate cancer is largely unknown. The aim of the present work was to evaluate the clinico-pathological value of monocarboxylate transporters (MCTs) expression, namely MCT1, MCT2 and MCT4, together with CD147 and gp70 as MCT1/4 and MCT2 chaperones, respectively, in prostate carcinoma. METHODS: Prostate tissues were obtained from 171 patients, who performed radical prostatectomy and 14 patients who performed cystoprostatectomy. Samples and clinico-pathological data were retrieved and organized into tissue microarray (TMAs) blocks. Protein expression was evaluated by immunohistochemistry in neoplastic (n = 171), adjacent non-neoplastic tissues (n = 135), PIN lesions (n = 40) and normal prostatic tissue (n = 14). Protein expression was correlated with patients' clinicopathologic characteristics. RESULTS: In the present study, a significant increase of MCT2 and MCT4 expression in the cytoplasm of tumour cells and a significant decrease in both MCT1 and CD147 expression in prostate tumour cells was observed when compared to normal tissue. All MCT isoforms and CD147 were expressed in PIN lesions. Importantly, for MCT2 and MCT4 the expression levels in PIN lesions were between normal and tumour tissue, which might indicate a role for these MCTs in the malignant transformation. Associations were found between MCT1, MCT4 and CD147 expressions and poor prognosis markers; importantly MCT4 and CD147 overexpression correlated with higher PSA levels, Gleason score and pT stage, as well as with perineural invasion and biochemical recurrence. CONCLUSIONS: Our data provides novel evidence for the involvement of MCTs in prostate cancer. According to our results, we consider that MCT2 should be further explored as tumour marker and both MCT4 and CD147 as markers of poor prognosis in prostate cancer. SN - 1471-2407 UR - https://www.unboundmedicine.com/medline/citation/21787388/Monocarboxylate_transporter_4__MCT4__and_CD147_overexpression_is_associated_with_poor_prognosis_in_prostate_cancer_ L2 - https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-11-312 DB - PRIME DP - Unbound Medicine ER -