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Mediterranean diet and type 2 diabetes risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study: the InterAct project.
Diabetes Care 2011; 34(9):1913-8DC

Abstract

OBJECTIVE

To study the association between adherence to the Mediterranean dietary pattern (MDP) and risk of developing type 2 diabetes, across European countries.

RESEARCH DESIGN AND METHODS

We established a case-cohort study including 11,994 incident type 2 diabetic case subjects and a stratified subcohort of 15,798 participants selected from a total cohort of 340,234 participants with 3.99 million person-years of follow-up, from eight European cohorts participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The relative Mediterranean diet score (rMED) (score range 0-18) was used to assess adherence to MDP on the basis of reported consumption of nine dietary components characteristic of the Mediterranean diet. Cox proportional hazards regression, modified for the case-cohort design, was used to estimate the association between rMED and risk of type 2 diabetes, adjusting for confounders.

RESULTS

The multiple adjusted hazard ratios of type 2 diabetes among individuals with medium (rMED 7-10 points) and high adherence to MDP (rMED 11-18 points) were 0.93 (95% CI 0.86-1.01) and 0.88 (0.79-0.97), respectively, compared with individuals with low adherence to MDP (0-6 points) (P for trend 0.013). The association between rMED and type 2 diabetes was attenuated in people <50 years of age, in obese participants, and when the alcohol, meat, and olive oil components were excluded from the score.

CONCLUSIONS

In this large prospective study, adherence to the MDP, as defined by rMED, was associated with a small reduction in the risk of developing type 2 diabetes in this European population.

Authors

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Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21788627

Citation

InterAct Consortium, et al. "Mediterranean Diet and Type 2 Diabetes Risk in the European Prospective Investigation Into Cancer and Nutrition (EPIC) Study: the InterAct Project." Diabetes Care, vol. 34, no. 9, 2011, pp. 1913-8.
InterAct Consortium, Romaguera D, Guevara M, et al. Mediterranean diet and type 2 diabetes risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study: the InterAct project. Diabetes Care. 2011;34(9):1913-8.
Romaguera, D., Guevara, M., Norat, T., Langenberg, C., Forouhi, N. G., Sharp, S., ... Wareham, N. J. (2011). Mediterranean diet and type 2 diabetes risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study: the InterAct project. Diabetes Care, 34(9), pp. 1913-8. doi:10.2337/dc11-0891.
InterAct Consortium, et al. Mediterranean Diet and Type 2 Diabetes Risk in the European Prospective Investigation Into Cancer and Nutrition (EPIC) Study: the InterAct Project. Diabetes Care. 2011;34(9):1913-8. PubMed PMID: 21788627.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mediterranean diet and type 2 diabetes risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study: the InterAct project. AU - ,, AU - Romaguera,D, AU - Guevara,M, AU - Norat,T, AU - Langenberg,C, AU - Forouhi,N G, AU - Sharp,S, AU - Slimani,N, AU - Schulze,M B, AU - Buijsse,B, AU - Buckland,G, AU - Molina-Montes,E, AU - Sánchez,M J, AU - Moreno-Iribas,M C, AU - Bendinelli,B, AU - Grioni,S, AU - van der Schouw,Y T, AU - Arriola,L, AU - Beulens,J W, AU - Boeing,H, AU - Clavel-Chapelon,F, AU - Cottet,V, AU - Crowe,F L, AU - de Lauzon-Guillan,B, AU - Franks,P W, AU - Gonzalez,C, AU - Hallmans,G, AU - Kaaks,R, AU - Key,T J, AU - Khaw,K, AU - Nilsson,P, AU - Overvad,K, AU - Palla,L, AU - Palli,D, AU - Panico,S, AU - Quirós,J R, AU - Rolandsson,O, AU - Romieu,I, AU - Sacerdote,C, AU - Spijkerman,A M W, AU - Teucher,B, AU - Tjonneland,A, AU - Tormo,M J, AU - Tumino,R, AU - van der,A D L, AU - Feskens,E J M, AU - Riboli,E, AU - Wareham,N J, Y1 - 2011/07/25/ PY - 2011/7/27/entrez PY - 2011/7/27/pubmed PY - 2012/5/12/medline SP - 1913 EP - 8 JF - Diabetes care JO - Diabetes Care VL - 34 IS - 9 N2 - OBJECTIVE: To study the association between adherence to the Mediterranean dietary pattern (MDP) and risk of developing type 2 diabetes, across European countries. RESEARCH DESIGN AND METHODS: We established a case-cohort study including 11,994 incident type 2 diabetic case subjects and a stratified subcohort of 15,798 participants selected from a total cohort of 340,234 participants with 3.99 million person-years of follow-up, from eight European cohorts participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The relative Mediterranean diet score (rMED) (score range 0-18) was used to assess adherence to MDP on the basis of reported consumption of nine dietary components characteristic of the Mediterranean diet. Cox proportional hazards regression, modified for the case-cohort design, was used to estimate the association between rMED and risk of type 2 diabetes, adjusting for confounders. RESULTS: The multiple adjusted hazard ratios of type 2 diabetes among individuals with medium (rMED 7-10 points) and high adherence to MDP (rMED 11-18 points) were 0.93 (95% CI 0.86-1.01) and 0.88 (0.79-0.97), respectively, compared with individuals with low adherence to MDP (0-6 points) (P for trend 0.013). The association between rMED and type 2 diabetes was attenuated in people <50 years of age, in obese participants, and when the alcohol, meat, and olive oil components were excluded from the score. CONCLUSIONS: In this large prospective study, adherence to the MDP, as defined by rMED, was associated with a small reduction in the risk of developing type 2 diabetes in this European population. SN - 1935-5548 UR - https://www.unboundmedicine.com/medline/citation/21788627/Mediterranean_diet_and_type_2_diabetes_risk_in_the_European_Prospective_Investigation_into_Cancer_and_Nutrition__EPIC__study:_the_InterAct_project_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&amp;pmid=21788627 DB - PRIME DP - Unbound Medicine ER -