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Metoclopramide versus ondansetron for the treatment of vomiting in children with acute gastroenteritis.
J Pediatr Gastroenterol Nutr. 2011 Aug; 53(2):156-60.JP

Abstract

OBJECTIVE

To compare the efficacy and safety of ondansetron versus less expensive metoclopramide in the treatment of children with persistent vomiting with acute gastroenteritis.

MATERIALS AND METHODS

A double-blind trial including consecutive consented patients ages 1 to 14 years was conducted in an urban infirmary setting from June 2008 through December 2008. Children were randomized to receive a single dose of intravenous ondansetron or metoclopramide. The primary efficacy outcome was the proportion of patients with cessation of vomiting shortly after completion of the study medication infusion in each group. Observed adverse effects and diarrhea frequency during admission and in follow-up were recorded to assess safety.

RESULTS

One hundred sixty-seven previously healthy children (median age 3 years) diagnosed as having acute gastroenteritis with persistent vomiting completed treatment and observation. Cessation of vomiting was achieved in 68/84 patients (81%) of the ondansetron and 60/83 (72%) of the metoclopramide groups, P = 0.14. Mean time to complete cessation of vomiting was 39 minutes (SD 111) for ondansetron, and 61 minutes (SD 110) for metoclopramide, P = 0.2. The mean length of infirmary stay was 550 minutes (SD 427) for ondansetron and 575 minutes (SD 449) for metoclopramide, P = 0.71. Revisit rate, readmissions rate, and frequency of diarrhea after discharge were similar in the 2 treatment groups. No adverse reaction or other safety concerns were identified.

CONCLUSIONS

In the sample size tested, intravenous metoclopramide therapy did not differ from ondansetron in the treatment of persistent vomiting for children with gastroenteritis admitted for intravenous fluid hydration.

Authors+Show Affiliations

Division of Pediatric Emergency Medicine, Department of Pediatrics, Hamad Medical Corporation, Doha, Qatar. dkmaa@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21788756

Citation

Al-Ansari, Khalid, et al. "Metoclopramide Versus Ondansetron for the Treatment of Vomiting in Children With Acute Gastroenteritis." Journal of Pediatric Gastroenterology and Nutrition, vol. 53, no. 2, 2011, pp. 156-60.
Al-Ansari K, Alomary S, Abdulateef H, et al. Metoclopramide versus ondansetron for the treatment of vomiting in children with acute gastroenteritis. J Pediatr Gastroenterol Nutr. 2011;53(2):156-60.
Al-Ansari, K., Alomary, S., Abdulateef, H., Alshawagfa, M., & Kamal, K. (2011). Metoclopramide versus ondansetron for the treatment of vomiting in children with acute gastroenteritis. Journal of Pediatric Gastroenterology and Nutrition, 53(2), 156-60. https://doi.org/10.1097/MPG.0b013e3182132d8d
Al-Ansari K, et al. Metoclopramide Versus Ondansetron for the Treatment of Vomiting in Children With Acute Gastroenteritis. J Pediatr Gastroenterol Nutr. 2011;53(2):156-60. PubMed PMID: 21788756.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metoclopramide versus ondansetron for the treatment of vomiting in children with acute gastroenteritis. AU - Al-Ansari,Khalid, AU - Alomary,Salim, AU - Abdulateef,Hala, AU - Alshawagfa,Mohammed, AU - Kamal,Khalid, PY - 2011/7/27/entrez PY - 2011/7/27/pubmed PY - 2011/12/13/medline SP - 156 EP - 60 JF - Journal of pediatric gastroenterology and nutrition JO - J Pediatr Gastroenterol Nutr VL - 53 IS - 2 N2 - OBJECTIVE: To compare the efficacy and safety of ondansetron versus less expensive metoclopramide in the treatment of children with persistent vomiting with acute gastroenteritis. MATERIALS AND METHODS: A double-blind trial including consecutive consented patients ages 1 to 14 years was conducted in an urban infirmary setting from June 2008 through December 2008. Children were randomized to receive a single dose of intravenous ondansetron or metoclopramide. The primary efficacy outcome was the proportion of patients with cessation of vomiting shortly after completion of the study medication infusion in each group. Observed adverse effects and diarrhea frequency during admission and in follow-up were recorded to assess safety. RESULTS: One hundred sixty-seven previously healthy children (median age 3 years) diagnosed as having acute gastroenteritis with persistent vomiting completed treatment and observation. Cessation of vomiting was achieved in 68/84 patients (81%) of the ondansetron and 60/83 (72%) of the metoclopramide groups, P = 0.14. Mean time to complete cessation of vomiting was 39 minutes (SD 111) for ondansetron, and 61 minutes (SD 110) for metoclopramide, P = 0.2. The mean length of infirmary stay was 550 minutes (SD 427) for ondansetron and 575 minutes (SD 449) for metoclopramide, P = 0.71. Revisit rate, readmissions rate, and frequency of diarrhea after discharge were similar in the 2 treatment groups. No adverse reaction or other safety concerns were identified. CONCLUSIONS: In the sample size tested, intravenous metoclopramide therapy did not differ from ondansetron in the treatment of persistent vomiting for children with gastroenteritis admitted for intravenous fluid hydration. SN - 1536-4801 UR - https://www.unboundmedicine.com/medline/citation/21788756/Metoclopramide_versus_ondansetron_for_the_treatment_of_vomiting_in_children_with_acute_gastroenteritis_ L2 - https://doi.org/10.1097/MPG.0b013e3182132d8d DB - PRIME DP - Unbound Medicine ER -