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Initial combined treatment with anticholinergics and α-blockers for men with lower urinary tract symptoms related to BPH and overactive bladder: a prospective, randomized, multi-center, double-blind, placebo-controlled study.
Prostate Cancer Prostatic Dis. 2011 Dec; 14(4):320-5.PC

Abstract

We aimed to evaluate the efficacy and safety of combination treatment using anticholinergics with α-blocker for initial treatment of both overactive bladder (OAB) and other lower urinary tract symptoms (LUTS), secondary to BPH. A 12-week, randomized, double-blind, placebo-controlled trial was conducted at four urology clinics in Korea, involving men, aged 50 years or older, with LUTS related to BPH and OAB. A total of 176 patients were randomly assigned to receive doxazosin (4 mg) plus placebo or doxazosin (4 mg) plus tolterodine SR (4 mg), once a day for 12 weeks. Changes from baseline in total International Prostate Symptom Score (IPSS), bladder diary variables, patient perception of bladder condition (PPBC), uroflowmetry, postvoid residual volume and IPSS subscores (voiding and storage) were analyzed. Of the 176 enrolled patients, 91 had doxazosin gastrointestinal therapeutic system (GITS) and placebo, and 85 had combined medication with doxazosin GITS and tolterodine SR. Compared with the doxazosin plus placebo group, the doxazosin plus tolterodine group showed significant reductions in IPSS storage subscore and improvement in the quality of life item, urgency episodes, as well as in micturition frequency at weeks 4 and 12. However, it failed to improve PPBC at week 4 as well as at week 12. Earlier intervention with anticholinergics plus α-blocker was tolerated well, including the questions about urinary retention (n=1) and dry mouth (n=2). Initial combination treatment of anticholinergics plus α-blocker showed positive results for men with LUTS related to BPH and OAB symptoms and did not increase the risk of urinary retention.

Authors+Show Affiliations

Department of Urology, Gangnam Severance Hospital, Yonsei University Health System, Seoul, Korea. uroljy@catholic.ac.krNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21788967

Citation

Lee, S H., et al. "Initial Combined Treatment With Anticholinergics and Α-blockers for Men With Lower Urinary Tract Symptoms Related to BPH and Overactive Bladder: a Prospective, Randomized, Multi-center, Double-blind, Placebo-controlled Study." Prostate Cancer and Prostatic Diseases, vol. 14, no. 4, 2011, pp. 320-5.
Lee SH, Chung BH, Kim SJ, et al. Initial combined treatment with anticholinergics and α-blockers for men with lower urinary tract symptoms related to BPH and overactive bladder: a prospective, randomized, multi-center, double-blind, placebo-controlled study. Prostate Cancer Prostatic Dis. 2011;14(4):320-5.
Lee, S. H., Chung, B. H., Kim, S. J., Kim, J. H., Kim, J. C., & Lee, J. Y. (2011). Initial combined treatment with anticholinergics and α-blockers for men with lower urinary tract symptoms related to BPH and overactive bladder: a prospective, randomized, multi-center, double-blind, placebo-controlled study. Prostate Cancer and Prostatic Diseases, 14(4), 320-5. https://doi.org/10.1038/pcan.2011.22
Lee SH, et al. Initial Combined Treatment With Anticholinergics and Α-blockers for Men With Lower Urinary Tract Symptoms Related to BPH and Overactive Bladder: a Prospective, Randomized, Multi-center, Double-blind, Placebo-controlled Study. Prostate Cancer Prostatic Dis. 2011;14(4):320-5. PubMed PMID: 21788967.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Initial combined treatment with anticholinergics and α-blockers for men with lower urinary tract symptoms related to BPH and overactive bladder: a prospective, randomized, multi-center, double-blind, placebo-controlled study. AU - Lee,S H, AU - Chung,B H, AU - Kim,S J, AU - Kim,J H, AU - Kim,J C, AU - Lee,J Y, Y1 - 2011/07/26/ PY - 2011/7/27/entrez PY - 2011/7/27/pubmed PY - 2012/7/14/medline SP - 320 EP - 5 JF - Prostate cancer and prostatic diseases JO - Prostate Cancer Prostatic Dis VL - 14 IS - 4 N2 - We aimed to evaluate the efficacy and safety of combination treatment using anticholinergics with α-blocker for initial treatment of both overactive bladder (OAB) and other lower urinary tract symptoms (LUTS), secondary to BPH. A 12-week, randomized, double-blind, placebo-controlled trial was conducted at four urology clinics in Korea, involving men, aged 50 years or older, with LUTS related to BPH and OAB. A total of 176 patients were randomly assigned to receive doxazosin (4 mg) plus placebo or doxazosin (4 mg) plus tolterodine SR (4 mg), once a day for 12 weeks. Changes from baseline in total International Prostate Symptom Score (IPSS), bladder diary variables, patient perception of bladder condition (PPBC), uroflowmetry, postvoid residual volume and IPSS subscores (voiding and storage) were analyzed. Of the 176 enrolled patients, 91 had doxazosin gastrointestinal therapeutic system (GITS) and placebo, and 85 had combined medication with doxazosin GITS and tolterodine SR. Compared with the doxazosin plus placebo group, the doxazosin plus tolterodine group showed significant reductions in IPSS storage subscore and improvement in the quality of life item, urgency episodes, as well as in micturition frequency at weeks 4 and 12. However, it failed to improve PPBC at week 4 as well as at week 12. Earlier intervention with anticholinergics plus α-blocker was tolerated well, including the questions about urinary retention (n=1) and dry mouth (n=2). Initial combination treatment of anticholinergics plus α-blocker showed positive results for men with LUTS related to BPH and OAB symptoms and did not increase the risk of urinary retention. SN - 1476-5608 UR - https://www.unboundmedicine.com/medline/citation/21788967/Initial_combined_treatment_with_anticholinergics_and_α_blockers_for_men_with_lower_urinary_tract_symptoms_related_to_BPH_and_overactive_bladder:_a_prospective_randomized_multi_center_double_blind_placebo_controlled_study_ L2 - https://doi.org/10.1038/pcan.2011.22 DB - PRIME DP - Unbound Medicine ER -