Tags

Type your tag names separated by a space and hit enter

Hydrolysis influence on phytochemical composition, antioxidant activity, plasma concentration, and tissue distribution of hydroethanolic Ilex paraguariensis extract components.
J Agric Food Chem. 2011 Aug 24; 59(16):8901-7.JA

Abstract

The infusion of aerial parts of Ilex paraguariensis is widely consumed. Its antioxidant activity suggests an important role of this plant in the treatment/prevention of oxidative stress related diseases. Plant extract active compounds are frequently found in esterified form that may be poorly absorbed. Hydrolysis of the extract is a possible approach to increase its bioavailability. The aim of this study was to perform a phytochemical analysis and evaluate in rats the plasma concentration and tissue distribution of antioxidant compounds in the hydroethanolic extract of Ilex paraguariensis, before and after enzymatic hydrolysis. Both extracts presented high antioxidant activity and phenolic content. Rats given single or repeated doses of the hydrolyzed extract showed increased plasma antioxidant activity and higher plasma levels of caffeic acid. However, no changes of endogenous antioxidants were observed. In conclusion, hydrolysis of the extract of Ilex paraguariensis is a strategy to improve its bioavailability and in vivo antioxidant activity.

Authors+Show Affiliations

School of Pharmaceutical Sciences, University of São Paulo, São Paulo SP, Brazil. diogopineda@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21790134

Citation

Rivelli, Diogo P., et al. "Hydrolysis Influence On Phytochemical Composition, Antioxidant Activity, Plasma Concentration, and Tissue Distribution of Hydroethanolic Ilex Paraguariensis Extract Components." Journal of Agricultural and Food Chemistry, vol. 59, no. 16, 2011, pp. 8901-7.
Rivelli DP, Almeida RL, Ropke CD, et al. Hydrolysis influence on phytochemical composition, antioxidant activity, plasma concentration, and tissue distribution of hydroethanolic Ilex paraguariensis extract components. J Agric Food Chem. 2011;59(16):8901-7.
Rivelli, D. P., Almeida, R. L., Ropke, C. D., & Barros, S. B. (2011). Hydrolysis influence on phytochemical composition, antioxidant activity, plasma concentration, and tissue distribution of hydroethanolic Ilex paraguariensis extract components. Journal of Agricultural and Food Chemistry, 59(16), 8901-7. https://doi.org/10.1021/jf201665t
Rivelli DP, et al. Hydrolysis Influence On Phytochemical Composition, Antioxidant Activity, Plasma Concentration, and Tissue Distribution of Hydroethanolic Ilex Paraguariensis Extract Components. J Agric Food Chem. 2011 Aug 24;59(16):8901-7. PubMed PMID: 21790134.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hydrolysis influence on phytochemical composition, antioxidant activity, plasma concentration, and tissue distribution of hydroethanolic Ilex paraguariensis extract components. AU - Rivelli,Diogo P, AU - Almeida,Rebeca L, AU - Ropke,Cristina D, AU - Barros,Silvia B M, Y1 - 2011/08/02/ PY - 2011/7/28/entrez PY - 2011/7/28/pubmed PY - 2011/12/14/medline SP - 8901 EP - 7 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 59 IS - 16 N2 - The infusion of aerial parts of Ilex paraguariensis is widely consumed. Its antioxidant activity suggests an important role of this plant in the treatment/prevention of oxidative stress related diseases. Plant extract active compounds are frequently found in esterified form that may be poorly absorbed. Hydrolysis of the extract is a possible approach to increase its bioavailability. The aim of this study was to perform a phytochemical analysis and evaluate in rats the plasma concentration and tissue distribution of antioxidant compounds in the hydroethanolic extract of Ilex paraguariensis, before and after enzymatic hydrolysis. Both extracts presented high antioxidant activity and phenolic content. Rats given single or repeated doses of the hydrolyzed extract showed increased plasma antioxidant activity and higher plasma levels of caffeic acid. However, no changes of endogenous antioxidants were observed. In conclusion, hydrolysis of the extract of Ilex paraguariensis is a strategy to improve its bioavailability and in vivo antioxidant activity. SN - 1520-5118 UR - https://www.unboundmedicine.com/medline/citation/21790134/Hydrolysis_influence_on_phytochemical_composition_antioxidant_activity_plasma_concentration_and_tissue_distribution_of_hydroethanolic_Ilex_paraguariensis_extract_components_ L2 - https://doi.org/10.1021/jf201665t DB - PRIME DP - Unbound Medicine ER -