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Three-component reaction of N'-(2-alkynylbenzylidene)hydrazide, alkyne, with sulfonyl azide via a multicatalytic process: a novel and concise approach to 2-amino-H-pyrazolo[5,1-a]isoquinolines.
Org Lett. 2011 Aug 19; 13(16):4312-5.OL

Abstract

A novel and efficient route for the synthesis of 2-amino-H-pyrazolo[5,1-a]isoquinolines via a three-component reaction of N'-(2-alkynylbenzylidene)hydrazide, alkyne, and sulfonyl azide is described. This transformation, co-catalyzed by silver triflate and copper(I) bromide under mild conditions, proceeds efficiently to generate the 2-amino-H-pyrazolo[5,1-a]isoquinolines in good to excellent yields.

Authors+Show Affiliations

Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21790168

Citation

Li, Shaoyu, et al. "Three-component Reaction of N'-(2-alkynylbenzylidene)hydrazide, Alkyne, With Sulfonyl Azide Via a Multicatalytic Process: a Novel and Concise Approach to 2-amino-H-pyrazolo[5,1-a]isoquinolines." Organic Letters, vol. 13, no. 16, 2011, pp. 4312-5.
Li S, Luo Y, Wu J. Three-component reaction of N'-(2-alkynylbenzylidene)hydrazide, alkyne, with sulfonyl azide via a multicatalytic process: a novel and concise approach to 2-amino-H-pyrazolo[5,1-a]isoquinolines. Org Lett. 2011;13(16):4312-5.
Li, S., Luo, Y., & Wu, J. (2011). Three-component reaction of N'-(2-alkynylbenzylidene)hydrazide, alkyne, with sulfonyl azide via a multicatalytic process: a novel and concise approach to 2-amino-H-pyrazolo[5,1-a]isoquinolines. Organic Letters, 13(16), 4312-5. https://doi.org/10.1021/ol201653j
Li S, Luo Y, Wu J. Three-component Reaction of N'-(2-alkynylbenzylidene)hydrazide, Alkyne, With Sulfonyl Azide Via a Multicatalytic Process: a Novel and Concise Approach to 2-amino-H-pyrazolo[5,1-a]isoquinolines. Org Lett. 2011 Aug 19;13(16):4312-5. PubMed PMID: 21790168.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Three-component reaction of N'-(2-alkynylbenzylidene)hydrazide, alkyne, with sulfonyl azide via a multicatalytic process: a novel and concise approach to 2-amino-H-pyrazolo[5,1-a]isoquinolines. AU - Li,Shaoyu, AU - Luo,Yong, AU - Wu,Jie, Y1 - 2011/07/26/ PY - 2011/7/28/entrez PY - 2011/7/28/pubmed PY - 2011/12/13/medline SP - 4312 EP - 5 JF - Organic letters JO - Org Lett VL - 13 IS - 16 N2 - A novel and efficient route for the synthesis of 2-amino-H-pyrazolo[5,1-a]isoquinolines via a three-component reaction of N'-(2-alkynylbenzylidene)hydrazide, alkyne, and sulfonyl azide is described. This transformation, co-catalyzed by silver triflate and copper(I) bromide under mild conditions, proceeds efficiently to generate the 2-amino-H-pyrazolo[5,1-a]isoquinolines in good to excellent yields. SN - 1523-7052 UR - https://www.unboundmedicine.com/medline/citation/21790168/Three_component_reaction_of_N'__2_alkynylbenzylidene_hydrazide_alkyne_with_sulfonyl_azide_via_a_multicatalytic_process:_a_novel_and_concise_approach_to_2_amino_H_pyrazolo[51_a]isoquinolines_ L2 - https://doi.org/10.1021/ol201653j DB - PRIME DP - Unbound Medicine ER -