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Chemical modification and anticancer effect of prenylated flavanones from Taiwanese propolis.
Nat Prod Res 2012; 26(2):116-24NP

Abstract

Our previous studies demonstrated that eight prenylated flavanones (1-8), isolated from Taiwanese propolis, were capable of a broad spectrum of biological activities. Among them, nymphaeol A (3), nymphaeol B (4) and nymphaeol C (7), abundant in Taiwanese propolis, exhibited cytotoxicity against cancer cell lines. It therefore seemed interesting to improve their activity via a semi-synthetic strategy. In this study, 12 novel prenylated flavanones were synthesised in our laboratory and their activities were assessed for two human prostate cancer cell lines, PC-3 and DU-145, and a human hepatoma cell line, Hep-3B. Of these compounds, 10c, 11 and 12 showed more potent cytotoxicity against the PC-3 cell line than 5-Fu. Using cytometric analysis followed by double staining with annexin V-FITC and propidium iodide, it was observed that these compounds induced apoptosis as well. This suggests that prenylated flavanones 10c, 11 and 12 may have anticancer potential for further development.

Authors+Show Affiliations

NatureWise Biotech & Medicals Corporation, Taipei 115, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21790499

Citation

Chen, Chia-Nan, et al. "Chemical Modification and Anticancer Effect of Prenylated Flavanones From Taiwanese Propolis." Natural Product Research, vol. 26, no. 2, 2012, pp. 116-24.
Chen CN, Hsiao CJ, Lee SS, et al. Chemical modification and anticancer effect of prenylated flavanones from Taiwanese propolis. Nat Prod Res. 2012;26(2):116-24.
Chen, C. N., Hsiao, C. J., Lee, S. S., Guh, J. H., Chiang, P. C., Huang, C. C., & Huang, W. J. (2012). Chemical modification and anticancer effect of prenylated flavanones from Taiwanese propolis. Natural Product Research, 26(2), pp. 116-24. doi:10.1080/14786419.2010.535146.
Chen CN, et al. Chemical Modification and Anticancer Effect of Prenylated Flavanones From Taiwanese Propolis. Nat Prod Res. 2012;26(2):116-24. PubMed PMID: 21790499.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemical modification and anticancer effect of prenylated flavanones from Taiwanese propolis. AU - Chen,Chia-Nan, AU - Hsiao,Che-Jen, AU - Lee,Shoei-Sheng, AU - Guh,Jih-Hwa, AU - Chiang,Po-Cheng, AU - Huang,Chih-Chiang, AU - Huang,Wei-Jan, Y1 - 2011/07/27/ PY - 2011/7/28/entrez PY - 2011/7/28/pubmed PY - 2012/4/10/medline SP - 116 EP - 24 JF - Natural product research JO - Nat. Prod. Res. VL - 26 IS - 2 N2 - Our previous studies demonstrated that eight prenylated flavanones (1-8), isolated from Taiwanese propolis, were capable of a broad spectrum of biological activities. Among them, nymphaeol A (3), nymphaeol B (4) and nymphaeol C (7), abundant in Taiwanese propolis, exhibited cytotoxicity against cancer cell lines. It therefore seemed interesting to improve their activity via a semi-synthetic strategy. In this study, 12 novel prenylated flavanones were synthesised in our laboratory and their activities were assessed for two human prostate cancer cell lines, PC-3 and DU-145, and a human hepatoma cell line, Hep-3B. Of these compounds, 10c, 11 and 12 showed more potent cytotoxicity against the PC-3 cell line than 5-Fu. Using cytometric analysis followed by double staining with annexin V-FITC and propidium iodide, it was observed that these compounds induced apoptosis as well. This suggests that prenylated flavanones 10c, 11 and 12 may have anticancer potential for further development. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/21790499/full_citation/Chemical_modification_and_anticancer_effect_of_prenylated_flavanones_from_Taiwanese_propolis_ L2 - http://www.tandfonline.com/doi/full/10.1080/14786419.2010.535146 DB - PRIME DP - Unbound Medicine ER -