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In vitro human skin permeation and cutaneous metabolism of catechins from green tea extract and green tea extract-loaded chitosan microparticles.

Abstract

Catechins are major antioxidants in green tea (Camellia sinensis or Camellia assamica), but because they do not permeate the skin well, the application of green tea in cosmetic products has so far been limited. This study aims to evaluate the cutaneous absorption of catechins from an extract of green tea and from a green tea extract-loaded chitosan microparticle. The catechin skin metabolism was also examined. The results suggest that chitosan microparticles significantly improve the ability of catechins to permeate skin. The cutaneous metabolism of the catechins significantly affected their permeation profiles. Epicatechin (EC) and epigallocatechin (EGC) penetrated the skin more than epigallocatechin gallate (EGCG) and epicatechin gallate (ECG). The galloyl groups in EGCG and ECG were enzymatically hydrolysed to EGC and EC, respectively. Dehydroxylation of catechins was also observed. Chitosan microparticles effectively prevented enzymatic changes of the catechins; therefore, chitosan microparticles are here found to be the promising carriers for enhancing the skin permeation.

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  • Authors+Show Affiliations

    ,

    Department of Pharmaceutical Technology and Center of Excellence for Innovation in Chemistry, Naresuan University, Thailand.

    , ,

    Source

    MeSH

    Administration, Cutaneous
    Camellia sinensis
    Catechin
    Chitosan
    Humans
    In Vitro Techniques
    Infant, Newborn
    Linear Models
    Male
    Microspheres
    Plant Extracts
    Skin
    Skin Absorption
    Tea

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21790662

    Citation

    Wisuitiprot, W, et al. "In Vitro Human Skin Permeation and Cutaneous Metabolism of Catechins From Green Tea Extract and Green Tea Extract-loaded Chitosan Microparticles." International Journal of Cosmetic Science, vol. 33, no. 6, 2011, pp. 572-9.
    Wisuitiprot W, Somsiri A, Ingkaninan K, et al. In vitro human skin permeation and cutaneous metabolism of catechins from green tea extract and green tea extract-loaded chitosan microparticles. Int J Cosmet Sci. 2011;33(6):572-9.
    Wisuitiprot, W., Somsiri, A., Ingkaninan, K., & Waranuch, N. (2011). In vitro human skin permeation and cutaneous metabolism of catechins from green tea extract and green tea extract-loaded chitosan microparticles. International Journal of Cosmetic Science, 33(6), pp. 572-9. doi:10.1111/j.1468-2494.2011.00673.x.
    Wisuitiprot W, et al. In Vitro Human Skin Permeation and Cutaneous Metabolism of Catechins From Green Tea Extract and Green Tea Extract-loaded Chitosan Microparticles. Int J Cosmet Sci. 2011;33(6):572-9. PubMed PMID: 21790662.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - In vitro human skin permeation and cutaneous metabolism of catechins from green tea extract and green tea extract-loaded chitosan microparticles. AU - Wisuitiprot,W, AU - Somsiri,A, AU - Ingkaninan,K, AU - Waranuch,N, Y1 - 2011/07/25/ PY - 2011/7/28/entrez PY - 2011/7/28/pubmed PY - 2012/3/20/medline SP - 572 EP - 9 JF - International journal of cosmetic science JO - Int J Cosmet Sci VL - 33 IS - 6 N2 - Catechins are major antioxidants in green tea (Camellia sinensis or Camellia assamica), but because they do not permeate the skin well, the application of green tea in cosmetic products has so far been limited. This study aims to evaluate the cutaneous absorption of catechins from an extract of green tea and from a green tea extract-loaded chitosan microparticle. The catechin skin metabolism was also examined. The results suggest that chitosan microparticles significantly improve the ability of catechins to permeate skin. The cutaneous metabolism of the catechins significantly affected their permeation profiles. Epicatechin (EC) and epigallocatechin (EGC) penetrated the skin more than epigallocatechin gallate (EGCG) and epicatechin gallate (ECG). The galloyl groups in EGCG and ECG were enzymatically hydrolysed to EGC and EC, respectively. Dehydroxylation of catechins was also observed. Chitosan microparticles effectively prevented enzymatic changes of the catechins; therefore, chitosan microparticles are here found to be the promising carriers for enhancing the skin permeation. SN - 1468-2494 UR - https://www.unboundmedicine.com/medline/citation/21790662/In_vitro_human_skin_permeation_and_cutaneous_metabolism_of_catechins_from_green_tea_extract_and_green_tea_extract_loaded_chitosan_microparticles_ L2 - https://doi.org/10.1111/j.1468-2494.2011.00673.x DB - PRIME DP - Unbound Medicine ER -